.... Here, we review recent data indicating that the activity of the Escherichia coli lac operon promoter also depends upon its chromosomal location. Factors that affect promoter activity include the binding of nucleoid-associated proteins to neighbouring sequences, supercoiling and the activity...

... © The Authors Journal compilation © 2015 Biochemical Society 2015 centriole centrosome detachment chromosome mitosis Although not essential for mitosis, centrosomes provide an advantage to organisms, especially when mitosis must be completed in a limited time-frame...

...Susan L. Forsburg Replication stress is a significant contributor to genome instability. Recent studies suggest that the centromere is particularly susceptible to replication stress and prone to rearrangements and genome damage, as well as chromosome loss. This effect is enhanced by loss...

...Hiroshi Sato; Shigeaki Saitoh The kinetochore, which forms on a specific chromosomal locus called the centromere, mediates interactions between the chromosome and the spindle during mitosis and meiosis. Abnormal chromosome rearrangements and/or neocentromere formation can cause the presence...

... ( [email protected] ). 24 1 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 catenane chromatin chromosome DNA knot protein folding recombinase supercoiling topoisomerase The structure and function of DNA and proteins are affected by the topology...

...David Vanneste; Vanessa Ferreira; Isabelle Vernos The bipolar spindle is a highly dynamic structure that assembles transiently around the chromosomes and provides the mechanical support and the forces required for chromosome segregation. Spindle assembly and chromosome movements rely...

... in overcoming protein–DNA barriers to replication and that may illustrate fundamental aspects of how duplication of protein-bound DNA is underpinned in all organisms. 1 email [email protected] 19 8 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 chromosome...

...David J. Sherratt; Lidia K. Arciszewska; Estelle Crozat; James E. Graham; Ian Grainge Escherichia coli FtsK is a septum-located DNA translocase that co-ordinates the late stages of cytokinesis and chromosome segregation. Relatives of FtsK are present in most bacteria; in Bacillus subtilis...

...Dan Liu; Michael A. Lampson Accurate segregation of chromosomes in mitosis requires that spindle microtubules attach sister kinetochores to opposite poles of the mitotic spindle (biorientation). To achieve biorientation of all chromosomes, incorrect attachments are selectively destabilized...

...Geert J.P.L. Kops Error-free chromosome segregation during cell division relies on chromosome biorientation and mitotic checkpoint activity. A group of unrelated kinases controls various aspects of both processes. The present short review outlines our current understanding of the roles...

... the development and exploitation of new visualization methods and reagents and show how they are contributing to the understanding of bacterial structure, chromosome organization, DNA metabolism and their relationship to the cell cycle. 1 To whom correspondence should be addressed (email david.sherratt...

...A. Zalensky; I. Zalenskaya Elaborate non-random organization of human sperm chromosomes at different structural levels, starting from the DNA packing by protamines up to the higher-order chromosome configuration and nuclear positioning of chromosome territories, has been discovered. Here, we put...

...C. Mézard Many studies have demonstrated that the distribution of meiotic crossover events along chromosomes is non-random in plants and other species with sexual reproduction. Large differences in recombination frequencies appear at several scales. On a large scale, regions of high and low rates...