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Biochem Soc Trans (2019) 47 (1): 187-196.
Published: 09 January 2019
... until it differentiates into a stalked cell. Its genome consists in a single circular chromosome whose replication is tightly regulated so that it happens only in stalked cells and only once per cell cycle. Imbalances in chromosomal copy numbers are the most often highly deleterious, if not lethal. This...
Jeffrey C. Hansen, Mark Connolly, Charles J. McDonald, Anyu Pan, Anna Pryamkova, Kyle Ray, Erik Seidel, Sachiko Tamura, Ryan Rogge, Kazuhiro Maeshima
Biochem Soc Trans (2018) 46 (1): 67-76.
Published: 20 December 2017
...Jeffrey C. Hansen; Mark Connolly; Charles J. McDonald; Anyu Pan; Anna Pryamkova; Kyle Ray; Erik Seidel; Sachiko Tamura; Ryan Rogge; Kazuhiro Maeshima A chromosome is a single long DNA molecule assembled along its length with nucleosomes and proteins. During interphase, a mammalian chromosome exists...
Biochem Soc Trans (2016) 44 (5): 1201-1217.
Published: 19 October 2016
...Bungo Akiyoshi The kinetochore is the macromolecular protein complex that drives chromosome segregation in eukaryotes. Its most fundamental function is to connect centromeric DNA to dynamic spindle microtubules. Studies in popular model eukaryotes have shown that centromere protein (CENP)-A is...