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Keyword: cilia
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Articles
Biochem Soc Trans (2018) 46 (6): 1463-1473.
Published: 21 November 2018
... microtubules (specifically, the acetylated microtubular axoneme of the photoreceptor connecting cilium) and their role in normal photoreceptor function. This has been driven by the emerging field of ciliopathies, human diseases arising from mutations in genes required for cilia formation or function, of which...
Articles
Biochem Soc Trans (2018) 46 (4): 967-982.
Published: 31 July 2018
... along the axoneme of eukaryotic cilia and flagella. Both dyneins operate as large ATP-driven motor complexes, whose dysfunction is associated with a group of human disorders. But how similar are their mechanisms of action and regulation? To examine this question, this review focuses on recent advances...
Articles
Biochem Soc Trans (2017) 45 (1): 37-49.
Published: 15 February 2017
..., these activities require activation of AURKA in early G1, and the mechanisms of activation are much less well defined than those in mitosis. A better understanding of the control of AURKA activity and the role of AURKA at cilia are both important in optimizing the efficacy and interpreting potential...
Articles
Biochem Soc Trans (2016) 44 (6): 1745-1751.
Published: 02 December 2016
... disease affects millions of people worldwide and although pharmacological treatments exist for some conditions, there are still patients whose only option is kidney dialysis and kidney transplantation. In the past 10 years, certain chronic kidney diseases have been reclassified as ciliopathies. Cilia in...
Articles
Biochem Soc Trans (2016) 44 (6): 1753-1759.
Published: 02 December 2016
... primordium and subsequent steps in the outgrowth of the mandibular skeleton. We then determine the critical tissue interactions using mice carrying a conditional mutation in the cilia gene Ofd1 . Our studies highlight the usefulness of the Ofd1 mouse model and illustrate long-term possibilities for...
Articles
Biochem Soc Trans (2016) 44 (5): 1273-1280.
Published: 19 October 2016
...Louise A. Stephen; Shehab Ismail Primary cilia are hair-like microtubule-based organelles that can be found on almost all human cell types. Although the cilium is not separated from the cell by membranes, their content is different from that of the cell body and their membrane composition is...
Articles
Biochem Soc Trans (2016) 44 (5): 1227-1234.
Published: 19 October 2016
...Samuel M. O'Toole; J. Paul Chapple Primary cilia are sensory organelles that play a role as signalling hubs. Disruption of primary cilia structure and function is increasingly recognised in a range of cancers, with a growing body of evidence suggesting that ciliary disruption contributes to...
Articles
Biochem Soc Trans (2016) 44 (5): 1265-1271.
Published: 19 October 2016
...Robert F. Shearer; Darren N. Saunders Primary cilia form at the surface of most vertebrate cell types, where they are essential signalling antennae for signal transduction pathways important for development and cancer, including Hedgehog. The importance of primary cilia in development is clearly...
Articles
Biochem Soc Trans (2016) 44 (5): 1245-1251.
Published: 19 October 2016
...David A. Parfitt; Amelia Lane; Conor Ramsden; Katarina Jovanovic; Peter J. Coffey; Alison J. Hardcastle; Michael E. Cheetham The photoreceptor cells in the retina have a highly specialised sensory cilium, the outer segment (OS), which is important for detecting light. Mutations in cilia-related...