...Dale W. Maxwell; Raymond T. O'Keefe; Sudipto Roy; Kathryn E. Hentges Cilia are critical to numerous biological functions, both in development and everyday homeostatic processes. Diseases arising from genetic mutations that cause cilia dysfunction are termed ciliopathies. Several ubiquitously...

.... The renal tubules are lined with epithelial cells that possess primary cilia that project into the lumen and act as sensory and signalling organelles. Mutations in genes encoding ciliary proteins involved in the structure and function of primary cilia cause ciliopathy syndromes and affect many organ systems...

... findings that link cilia and the DDR and explores the various roles played by key genes in these two contexts. It outlines how proteins encoded by ciliary genes impact checkpoint signalling, DNA replication and repair, gene expression and chromatin remodelling. It discusses how these diverse activities may...

...Pablo Barbeito; Francesc R. Garcia-Gonzalo Primary cilia are hair-like projections of the cell membrane supported by an inner microtubule scaffold, the axoneme, which polymerizes out of a membrane-docked centriole at the ciliary base. By working as specialized signaling compartments, primary cilia...

... (CC BY) . cancer stem cells centrosomes cilia KRAS trafficking During the morphogenesis of normal tissues, the balance between stem cell self-renewal and differentiation is regulated by symmetric and asymmetric cell divisions [ 1 ]. Certain features of these ontogenetic processes...

...). Published by Portland Press Limited on behalf of the Biochemical Society 2020 asthma chronic obstructive pulmonary disease cilia cystic fibrosis mucus Xenopus Correspondence: Eamon Dubaissi ( eamon.dubaissi@manchester.ac.uk ) As ciliated cells differentiate, cilia are generated...

...Manuela Morleo; Brunella Franco The OFD1 gene was initially identified as the gene responsible for the X-linked dominant male lethal OFD type I syndrome, a developmental disorder ascribed to cilia disfunction. The transcript has been subsequently associated to four different X-linked recessive...

...Jean-André Lapart; Amélie Billon; Jean-Luc Duteyrat; Joëlle Thomas; Bénédicte Durand Cilia play important signaling or motile functions in various organisms. In Human, cilia dysfunctions are responsible for a wide range of diseases, called ciliopathies. Cilia assembly is a tightly controlled...

... pathways to create the elaborately branched structure of the lung by controlling the directional protrusive movements of cells during branching morphogenesis. PCP operates in the airway epithelium to establish and maintain the orientation of respiratory cilia along the airway axis for anatomically directed...

... of microtubules (specifically, the acetylated microtubular axoneme of the photoreceptor connecting cilium) and their role in normal photoreceptor function. This has been driven by the emerging field of ciliopathies, human diseases arising from mutations in genes required for cilia formation or function, of which...

... along the axoneme of eukaryotic cilia and flagella. Both dyneins operate as large ATP-driven motor complexes, whose dysfunction is associated with a group of human disorders. But how similar are their mechanisms of action and regulation? To examine this question, this review focuses on recent advances...

..., these activities require activation of AURKA in early G1, and the mechanisms of activation are much less well defined than those in mitosis. A better understanding of the control of AURKA activity and the role of AURKA at cilia are both important in optimizing the efficacy and interpreting potential downstream...

... primordium and subsequent steps in the outgrowth of the mandibular skeleton. We then determine the critical tissue interactions using mice carrying a conditional mutation in the cilia gene Ofd1 . Our studies highlight the usefulness of the Ofd1 mouse model and illustrate long-term possibilities...

... disease affects millions of people worldwide and although pharmacological treatments exist for some conditions, there are still patients whose only option is kidney dialysis and kidney transplantation. In the past 10 years, certain chronic kidney diseases have been reclassified as ciliopathies. Cilia...

...Samuel M. O'Toole; J. Paul Chapple Primary cilia are sensory organelles that play a role as signalling hubs. Disruption of primary cilia structure and function is increasingly recognised in a range of cancers, with a growing body of evidence suggesting that ciliary disruption contributes...

...Robert F. Shearer; Darren N. Saunders Primary cilia form at the surface of most vertebrate cell types, where they are essential signalling antennae for signal transduction pathways important for development and cancer, including Hedgehog. The importance of primary cilia in development is clearly...

...Louise A. Stephen; Shehab Ismail Primary cilia are hair-like microtubule-based organelles that can be found on almost all human cell types. Although the cilium is not separated from the cell by membranes, their content is different from that of the cell body and their membrane composition...

...David A. Parfitt; Amelia Lane; Conor Ramsden; Katarina Jovanovic; Peter J. Coffey; Alison J. Hardcastle; Michael E. Cheetham The photoreceptor cells in the retina have a highly specialised sensory cilium, the outer segment (OS), which is important for detecting light. Mutations in cilia-related...