... cancer caveolae clathrin endocytosis signaling ITSNs may regulate the trafficking and signaling of multiple receptors through interaction with Rab GTPases, the largest subfamily of Ras GTPases that regulate all aspects of vesicle trafficking [ 30 ]. ITSN1-S interacts with many Rab-binding...

... each step, the actin cytoskeleton contributes to all. However, its role can be indirect to the actual molecular events driving endocytosis. Here, we review our understanding of the molecular steps mediating local actin polymerization during the formation of endocytic carriers. Clathrin-mediated...

...Sebastian Y. Bednarek; Steven K. Backues Two separate families of Arabidopsis dynamin-related proteins, DRP1 and DRP2, have been implicated in clathrin-mediated endocytosis and cell plate maturation during cytokinesis. The present review summarizes the current genetic, biochemical and cell...

...Arndt Pechstein; Oleg Shupliakov; Volker Haucke During neurotransmitter release, SVs (synaptic vesicles) fuse at the active zone and are recovered predominantly via clathrin-mediated endocytosis at the presynaptic compartment surrounding the site of release, referred to as the periactive zone. Exo...

... via the direct binding of specific endocytosis motifs within the intracellular domains of receptor β 1-3 and γ 2 subunits to the clathrin adaptor protein AP2 (adaptor protein 2). These binding motifs contain major sites of both serine and tyrosine phosphorylation within GABA A Rs...

... correspondence should be addressed (email [email protected] ). 23 4 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 β-arrestin bioluminescence resonance energy transfer (BRET) clathrin G-protein-coupled receptor (GPCR) live-cell imaging protein–protein...

...G.J. Augustine; J.R. Morgan; C.A. Villalba-Galea; S. Jin; K. Prasad; E.M. Lafer The role of clathrin-mediated endocytosis in SV (synaptic vesicle) recycling has been studied by combining molecular biology, physiology and electron microscopy at the squid giant synapse. Procedures that prevent...

...V. Haucke Endocytosis of transmembrane receptors largely occurs via clathrin-coated vesicles that bud from the plasma membrane and deliver their cargo to the endosomal system for recycling or degradation. PIs (phosphoinositides) control the timing and localization of endocytic membrane trafficking...

...D.J. Owen Clathrin-mediated endocytosis is the major process by which transmembrane proteins are internalized from the cell's limiting membrane into the first compartment of the endosomal system, the early endosome. From here, these transmembrane cargo proteins, which are of widely varying type...