...Jonathan Neve; André Furger With the advances in deep-sequencing techniques over the last decade, the study of alternative cleavage and polyadenylation (APA) has shifted from individual gene to whole transcriptome analysis. Findings from such global studies have elevated APA to its currently...

...Hilary E.M. McMahon The events leading to the degradation of the endogenous PrP C (normal cellular prion protein) have been the subject of numerous studies. Two cleavage processes, α-cleavage and β-cleavage, are responsible for the main C- and N-terminal fragments produced from PrP C . Both...

... systems are described briefly in the present review. 1 email [email protected] 2 3 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 cleavage long terminal repeat polyadenylation splicing transcription U1 small nuclear RNA (U1 snRNA) Human...

...Gregor Obernosterer; Hakim Tafer; Javier Martinez In RNAi (RNA interference), siRNAs (small interfering RNAs) are loaded into the RISC (RNA-induced silencing complex), which then mediates endonucleolytic cleavage of complementary target RNAs. Although RNAi has become one of the most powerful tools...

... )-octadecatrienoic acid, 13-HPOT] into volatile C 5 and non-volatile C 13 oxo-products. This enzymic activity initially was attributed to a hydroperoxide lyase enzyme; however, subsequent studies showed that this cleavage activity is the result of lipoxygenase activity under anaerobic conditions. Headspace analysis...