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Keywords: co-stimulation
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Biochem Soc Trans (2004) 32 (2): 332–335.
Published: 01 April 2004
... CD28 co-stimulation is blocked or not required. Recruitment and activation of PI3K by CD28 promotes survival by inducing increased expression of Bcl-X L . However, CD28 engages additional signals that regulate proliferation and interleukin-2 production independently of PI3K. Thus a model emerges...