...Tomas L. Lindahl; Sofia Ramström; Niklas Boknäs; Lars Faxälv Platelet-derived polyphosphates (polyP), stored in dense granule and released upon platelet activation, have been claimed to enhance thrombin activation of coagulation factor XI (FXI) and to activate FXII directly. The latter claim...

... monomers in length. These linear polymers act at various points in the coagulation and fibrinolytic systems thereby modulating the haemostatic response. Due to its highly anionic nature, polyP lends itself to being a natural activator of the contact system. The contact system functions in multiple pathways...

... on tumour biology. Of particular interest is the potential role of extracellular vesicles as orchestrators of common features of the malignant tumour microenvironment, e.g. coagulation activation and angiogenesis. 1 To whom correspondence should be addressed (email [email protected]...

...A. Amour; J. Hutchinson; A.M. Ruiz Avendaño; S. Ratcliffe; E. Alvarez; J. Martin; J.R. Toomey; S. Senger; M. Wolfendale; C. Mooney Coagulation proteases are involved in a highly orchestrated proteolytic cascade which is essential for haemostasis and blood clotting. In particular, the initiator...

... a balance between coagulation and fibrinolysis to maintain the integrity of the vasculature, and complex physiological changes are evident during pregnancy which appear to ensure a constant coagulation/fibrinolysis balance. This balance is maintained, at least partly, by an increase in fibrinolytic activity...

...K.-E. Eilertsen; B. Østerud The transmembrane glycoprotein TF (tissue factor) plays an essential role in haemostasis as the principal initiator of blood coagulation. In this paper, we describe how the circulating blood cells – monocytes, platelets, neutrophils and their microparticles – co-operate...