... of catalytic activity. coenzyme A lipid metabolism lipid transfer The hallmark characteristic of type II ACOTs is an enzymatic hot dog domain, which comprises a 5–7 stranded antiparallel β-sheet containing a 5-turn α-helix [ 25 ]. ACOT11 and ACOT12 each have two of these enzymatic hot dog...

...Ivan Gout Coenzyme A (CoA) is an indispensable cofactor in all living organisms. It is synthesized in an evolutionarily conserved pathway by enzymatic conjugation of cysteine, pantothenate (Vitamin B5), and ATP. This unique chemical structure allows CoA to employ its highly reactive thiol group...

...Ivan Gout In a diverse family of cellular cofactors, coenzyme A (CoA) has a unique design to function in various biochemical processes. The presence of a highly reactive thiol group and a nucleotide moiety offers a diversity of chemical reactions and regulatory interactions. CoA employs them...

...Suzanne Jackowski; Roberta Leonardi CoA (coenzyme A) is an essential cofactor that is emerging as a global regulator of energy metabolism. Tissue CoA levels are tightly regulated and vary in response to different conditions including nutritional state and diabetes. Recent studies reveal the ability...

...Yugo Tsuchiya; Uyen Pham; Ivan Gout CoA (coenzyme A) is a ubiquitous and essential cofactor that acts as an acyl group carrier in biochemical reactions. Apart from participating in numerous metabolic pathways as substrates and intermediates, CoA and a number of its thioester derivatives...