...Antonio Valdés; Christian H. Haering Structural maintenance of chromosomes (SMC) protein complexes, including cohesin, condensin, and the Smc5/6 complex, are integral to various processes in chromosome biology. Despite their distinct roles, these complexes share two key properties: the ability...

... BY) . archaea CID cohesin condensin SMC TAD The seminal studies of Woese and Fox revealed Archaea to be a distinct domain of life from Bacteria and Eukaryotes [ 1 ]. More recent advances in phylogenetic methods, coupled with massively increased taxonomic sampling have revealed deep divisions...

...Raquel A. Oliveira; Kim Nasmyth Sister-chromatid cohesion, thought to be primarily mediated by the cohesin complex, is essential for chromosome segregation. The forces holding the two sisters resist the tendency of microtubules to prematurely pull sister DNAs apart and thereby prevent random...

... transition and the sisters separate. In budding yeast, this sister chromatid cohesion requires a multi-protein complex called cohesin. A key component of cohesin is Scc1/Mcd1 (Rad21 in fission yeast). Disruption of the chicken orthologue of Scc1 by gene targeting in DT40 cells causes premature sister...