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Keywords: colorectal cancer
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Articles
Biochem Soc Trans (2022) 50 (1): 223–230.
Published: 15 February 2022
... the bioactivity of the IL-36 subfamily and its role in the pathogenesis of intestinal diseases such as inflammatory bowel disease, colorectal cancer, gut dysbacteriosis and infection, and proposes that IL-36 may be a target for novel therapeutic strategies to prevent or treat intestinal diseases...
Articles
Biochem Soc Trans (2016) 44 (6): 1683–1693.
Published: 02 December 2016
...); published by Portland Press Limited on behalf of the Biochemical Society 2016 colorectal cancer endometrial cancer glioma LCMT-1 neuroendocrine prostate cancer PTPA A recent report has suggested that PME-1 methylesterase activity protects PP2A-C from ubiquitin/proteasome degradation...
Articles
Biochem Soc Trans (2008) 36 (6): 1350–1353.
Published: 19 November 2008
... as laminopathies. However, a new role for lamin A has been discovered in the progression of a common epithelial cancer. CRC (colorectal cancer) patients expressing lamin A/C in their tumour tissue were found to have a 2-fold greater risk of CRC-related mortality compared with patients with lamin A/C-negative...
Articles
Biochem Soc Trans (2007) 35 (5): 1355–1357.
Published: 25 October 2007
...G.G.C. Kuhnle; S.A. Bingham Colorectal cancer is the third most common cancer in developed countries such as the U.K., but incidence rates around the world vary approx. 20-fold. Diet is thought to be a key factor determining risk: red and processed meat, but not white meat or fish, are associated...
Articles
Biochem Soc Trans (2007) 35 (5): 1372–1374.
Published: 25 October 2007
... appropriate inhibitors to identify stage-specific events. We have adopted this approach to study a group of benzyl- O - N -acetyl- D -galactosamine analogues in human colorectal cancer cell lines. Exposure to O-glycan inhibitors resulted in the induction of apoptosis, a block in proliferation, accumulation...
Articles
Biochem Soc Trans (2007) 35 (2): 364–368.
Published: 20 March 2007
...F.R. Saunders; H.M. Wallace Colorectal cancer is one of a number of cancers that may be amenable to prevention. The NSAIDs (non-steroidal anti-inflammatory drugs) have been shown to be effective chemopreventative agents in humans, but their mechanism of action is not clear. The polyamines...
Articles
Biochem Soc Trans (2005) 33 (4): 730–732.
Published: 01 August 2005
... on its presence in the extracellular matrix, we decided to investigate DMBT1 expression, location and its mode of secretion during malignant transformation in colorectal cancer. Using human colorectal PC/AA cell lines and tissue sections from individual patients, we have examined the expression of DMBT1...
Articles
Biochem Soc Trans (2005) 33 (4): 665–666.
Published: 01 August 2005
.... Therefore, from a very early stage in colorectal cancer, there are a number of molecules that can be used as markers for colorectal cancer and potentially as targets for chemoprevention. Given our improved understanding of the very early stages of colorectal cancer and the phenotype of APC-deficient cells...
Articles
Biochem Soc Trans (2005) 33 (4): 689–693.
Published: 01 August 2005
...S.J. Scherer; E. Avdievich; W. Edelmann Mutations in MMR (DNA mismatch repair) genes underlie HNPCC (hereditary non-polyposis colon cancer) and also a significant proportion of sporadic colorectal cancers. MMR maintains genome stability and suppresses tumour formation by correcting DNA replication...
Articles
Biochem Soc Trans (2005) 33 (4): 721–723.
Published: 01 August 2005
... a library of O-glycosylation inhibitors based on benzyl- O - N -acetyl- D -galactosamine. These inhibitors were tested with an established series of human colorectal cancer cell lines, which model the adenoma-carcinoma sequence. Cancer cells were incubated with the inhibitors, and examined for cell growth...
Articles
Biochem Soc Trans (2005) 33 (4): 694–697.
Published: 01 August 2005
... proteins involved in the Wnt-pathway. These include the p53-inducible Siah-1 protein [ 32 ] and a retinoid X receptor [ 33 ]. The contribution of these additional pathways to the regulation of β-catenin in colorectal cancer is not understood. The intricate interplay of different protein interactions...
Articles
Biochem Soc Trans (2005) 33 (4): 701–704.
Published: 01 August 2005
...) signalling and COX. 1 To whom correspondence should be addressed (email kashfi@med.cuny.edu ). 22 3 2005 © 2005 The Biochemical Society 2005 apoptosis colorectal cancer COX-2 (cyclo-oxygenase-2) NF-κB (nuclear factor κB) nitric-oxide-donating aspirin pancreatic cancer...
Articles
Biochem Soc Trans (2005) 33 (4): 684–688.
Published: 01 August 2005
... cancer. 1 email wgrady@fhcrc.org 22 3 2005 © 2005 The Biochemical Society 2005 Colorectal cancer develops as the result of the progressive accumulation of genetic and epigenetic alterations that lead to the transformation of normal colonic epithelium to colon adenocarcinoma...
Articles
Biochem Soc Trans (2005) 33 (4): 709–711.
Published: 01 August 2005
... a colorectal cancer cell line (SW48) to show that the ESR1 CGI is methylated in an allele-specific manner. This provides support for the ‘all or none’ mechanism for methylation of this gene, and shows how age-dependent methylation of the ESR1 CGI leads rapidly to silencing of the gene within the cells...
Articles
Biochem Soc Trans (2005) 33 (4): 679–683.
Published: 01 August 2005
... of oxidative damage to DNA. However, the full genetic pathway of MAP tumorigenesis has not been elucidated. 1 To whom correspondence should be addressed (email sampson@cardiff.ac.uk ). 29 3 2005 © 2005 The Biochemical Society 2005 adenomatous polyposis coli (APC) colorectal cancer...