... regulatory mechanisms that result in compartmentalized signalling. The use of fluorescent probes to monitor cAMP in intact, living cells have been instrumental in furthering our appreciation of this ancestral and ubiquitous pathway and unexpected details of the nano-architecture of the cAMP signalling...

.... It is now apparent that GPCR signalling is restricted to highly organized compartments within the cell, and that GPCRs activate distinct signalling pathways once internalized. A high-resolution understanding of how compartmentalized signalling is controlled will probably provide unique opportunities...

...Konstantinos Lefkimmiatis Mitochondria are highly dynamic organelles comprising at least three distinct areas, the OMM (outer mitochondrial membrane), the IMS (intermembrane space) and the mitochondrial matrix. Physical compartmentalization allows these organelles to host different functional...

... To whom correspondence should be addressed (email [email protected] ). 19 12 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 A-kinase-anchoring protein (AKAP) cAMP compartmentalization phosphodiesterase (PDE) platelet protein kinase A (PKA...

... Ras genes are not functionally redundant; this has been attributed to their distinctive trafficking and localization profiles. A palmitoylation cycle controls the correct compartmentalization of H-Ras and N-Ras. We review recent data that reveal how this cycle can be regulated by membrane organization...

... within the cell [ 8 , 9 ]. The present review focuses on new insights into the organization of discrete cellular microdomains in which the Ca 2+ -sensitive ACs reside and are regulated. adenylate cyclase (AC) A-kinase-anchoring protein (AKAP) biosensor compartmentalization Orai1 store-operated...

... by specific PDEs, establishing local pools of cAMP close to the effector molecules. A-kinase-anchoring protein (AKAP) cAMP compartmentalization extracellular-signal-regulated kinase (ERK) phosphodiesterase (PDE) protein kinase A (PKA) cAMP activates Epac (exchange protein directly activated...

... compartmentalization protein kinase A (PKA) Although the investigation of cAMP signalling has been underway for over 50 years, it was not until the early 1980s that the compartmentalized modulation of these events was appreciated. This concept developed from physiological experiments showing that stimulation...

.... Mol. Cell. Biol. 1999 19 6286 6296 11 Dodge K.L. Khouangsathiene S. Kapiloff M.S. Mouton R. Hill E.V. Houslay M.D. Langeberg L.K. Scott J.D. EMBO J. 2001 20 1921 1930 cAMP compartmentalization heart failure phosphodiesterase 3B (PDE3B...

... of bacterial periplasmic binding proteins and by computational design of the binding pockets of the prototype sensors. 17 9 2004 © 2005 The Biochemical Society 2005 compartmentalization fluorescence resonance energy transfer (FRET) imaging metabolites nanosensor subcellular 1...