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Keyword: compartmentalization
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Biochem Soc Trans (2019) 47 (5): 1383-1392.
Published: 31 October 2019
... local regulatory mechanisms that result in compartmentalized signalling. The use of fluorescent probes to monitor cAMP in intact, living cells have been instrumental in furthering our appreciation of this ancestral and ubiquitous pathway and unexpected details of the nano-architecture of the cAMP...
Biochem Soc Trans (2016) 44 (2): 562-567.
Published: 11 April 2016
.... It is now apparent that GPCR signalling is restricted to highly organized compartments within the cell, and that GPCRs activate distinct signalling pathways once internalized. A high-resolution understanding of how compartmentalized signalling is controlled will probably provide unique opportunities...
Biochem Soc Trans (2014) 42 (2): 265-269.
Published: 20 March 2014
...Konstantinos Lefkimmiatis Mitochondria are highly dynamic organelles comprising at least three distinct areas, the OMM (outer mitochondrial membrane), the IMS (intermembrane space) and the mitochondrial matrix. Physical compartmentalization allows these organelles to host different functional...
Biochem Soc Trans (2014) 42 (2): 289-294.
Published: 20 March 2014
... whom correspondence should be addressed (email khalid.naseem@hyms.ac.uk ). 19 12 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 A-kinase-anchoring protein (AKAP) cAMP compartmentalization phosphodiesterase (PDE) platelet protein kinase A (PKA...
Biochem Soc Trans (2013) 41 (1): 79-83.
Published: 29 January 2013
... Ras genes are not functionally redundant; this has been attributed to their distinctive trafficking and localization profiles. A palmitoylation cycle controls the correct compartmentalization of H-Ras and N-Ras. We review recent data that reveal how this cycle can be regulated by membrane organization...
Biochem Soc Trans (2012) 40 (1): 246-250.
Published: 19 January 2012
... regulation of cAMP signalling by SOCE. 1 email dw212@cam.ac.uk 14 6 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 adenylate cyclase (AC) A-kinase-anchoring protein (AKAP) biosensor compartmentalization Orai1 store-operated calcium entry (SOCE...
Biochem Soc Trans (2007) 35 (5): 931-937.
Published: 25 October 2007
...) cAMP compartmentalization extracellular-signal-regulated kinase (ERK) phosphodiesterase (PDE) protein kinase A (PKA) (D-)AKAP(- is ) (dual-specific) A-kinase-anchoring protein ( in silico ) Epac exchange protein directly activated by cAMP ERK extracellular-signal-regulated...
Biochem Soc Trans (2006) 34 (4): 465-467.
Published: 21 July 2006
... compartmentalization protein kinase A (PKA) Although the investigation of cAMP signalling has been underway for over 50 years, it was not until the early 1980s that the compartmentalized modulation of these events was appreciated. This concept developed from physiological experiments showing that stimulation of...
Biochem Soc Trans (2006) 34 (4): 502-503.
Published: 21 July 2006
... should be addressed (email alessia.perino@libero.it ). 23 3 2006 © 2006 The Biochemical Society 2006 cAMP compartmentalization heart failure phosphodiesterase 3B (PDE3B) phosphoinositide 3-kinase γ (PI3Kγ) signal transduction PI3Ks (phosphoinositide 3-kinases) are best known...
Biochem Soc Trans (2005) 33 (1): 287-290.
Published: 01 February 2005
... of bacterial periplasmic binding proteins and by computational design of the binding pockets of the prototype sensors. 1 To whom correspondence should be addressed (email wfrommer@stanford.edu ). 17 9 2004 © 2005 The Biochemical Society 2005 compartmentalization...