... ]. Correspondence: Erika Fernández-Vizarra ( [email protected] ) * Present address: Department of Neurology, University of Miami Miller School of Medicine, Miami, FL 33136, U.S.A. 30 1 2024 12 3 2024 14 3 2024 complex IV mitochondrial dysfunction reactive oxygen...

... by the reduction in molecular oxygen at Complex IV, cytochrome c oxidase (C c O) that is coupled with the proton pumping from the matrix to the inner membrane space. Unlike the ET reactions from Complex I to Complex III, the ET reaction to C c O, mediated by cytochrome c (Cyt c ), is quite specific...

... of the Biochemical Society 2022 complex IV cytochrome c electron transport chain infrared light mitochondria reactive oxygen species Ischemia occurs when blood supply to a tissue is compromised. Restoration of blood flow is crucial to prevent death of the ischemic tissue. Unfortunately...

... Society 2017 allosteric regulation complex IV conformational change proton pathways In the present study, we summarize the data that point to the importance of the K-path in the regulation of C c O activity, emphasizing the potential mechanistic implications of ligand effects and redox...

... to provide a proton translocation pathway [ 24 ] that may be unique to mammalian C c Os. complex IV electron transport chain energy coupling oxygen reduction proton transfer respiratory chain Electron flow along mitochondrial respiratory chains is dependent on a constant supply of oxygen...