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Keywords: conformational change
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Articles
Biochem Soc Trans (2017) 45 (5): 1087–1095.
Published: 25 August 2017
... paper summarizes evidence for two modes of regulation of activity: first, by redox-induced conformational changes involving the K-proton uptake path; and secondly, by ligand binding to a conserved site immediately adjacent to the entrance of the K-path that leads to the active site. Both these phenomena...
Articles
Biochem Soc Trans (2014) 42 (6): 1477–1483.
Published: 17 November 2014
... neurodegeneration [ 25 ]. Specifically, H 2 O 2 causes oxidation of cysteine residues within the C1B domain of PKCγ, inducing conformational changes that release PKCγ from its scaffold, leading to its translocation to the plasma membrane and subsequent DAG-independent activation [ 26 , 27 ]. PKCδ is phosphorylated...
Articles
Biochem Soc Trans (2013) 41 (5): 1219–1226.
Published: 23 September 2013
... changes of ϵ. The present mini-review summarizes smFRET rotation experiments and previews new smFRET data on the conformational changes of the CTD (C-terminal domain) of ϵ in the E. coli enzyme. 1 Correspondence may be addressed to either author (email michael.boersch@med.uni-jena.de or duncant...
Articles
Biochem Soc Trans (2013) 41 (2): 620–624.
Published: 21 March 2013
... knotted protein translocation, which show how the knot can indeed block the pore. 1 email piotr.szymczak@fuw.edu.pl 1 11 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 conformational change knot mitochondrion molecular dynamics protein...
Articles
Biochem Soc Trans (2013) 41 (1): 205–212.
Published: 29 January 2013
...: Center for Biomembrane Research, Department of Biochemistry and Biophysics, Stockholm University, SE-10691, Stockholm, Sweden. 30 10 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 allosteric regulation conformational change GPCR (G-protein-coupled receptor...
Articles
Biochem Soc Trans (2009) 37 (2): 354–357.
Published: 20 March 2009
... comprises an initial photochemical reaction, which is followed by a number of ‘dark’ steps. The latter steps in the reaction cycle have been shown to involve a series of ordered product release and substrate rebinding events and are known to require conformational changes in the protein in order to proceed...
Articles
Biochem Soc Trans (2009) 37 (2): 387–391.
Published: 20 March 2009
.... In addition, it has been demonstrated that a light-activated conformational change of the protein is necessary to activate catalysis. This makes POR a very important model system to study the relationship between structural changes of enzymes and functionality. 1 To whom correspondence should...
Articles
Biochem Soc Trans (2008) 36 (5): 971–975.
Published: 19 September 2008
... translocation. Owing to this, a conformation-linked mechanism for redox-driven proton translocation is discussed. By means of electron microscopy, we show that both arms of the Escherichia coli complex I are widened after the addition of NADH but not of NADPH. NADH-induced conformational changes were also...
Articles
Biochem Soc Trans (2006) 34 (1): 162–164.
Published: 20 January 2006
... the protein competent to respond to the nitrogen signal conveyed by the signal transduction protein GlnK have also been isolated. Our results suggest that the topological relationship between the central region and the GHKL domain may alter as a consequence of conformational changes induced in...
Articles
Biochem Soc Trans (2004) 32 (5): 721–723.
Published: 26 October 2004
... ligand binding and low-pH ligand release. 1 Correspondence may be addressed to either of these authors (email sblacklow@rics.bwh.harvard.edu or nbeglova@rics.bwh.harvard.edu ). 1 7 2004 © 2004 The Biochemical Society 2004 conformational change interdomain linkers ligand...
Articles
Biochem Soc Trans (2003) 31 (3): 631–633.
Published: 01 June 2003
...B.A. Wallace; Robert W. Janes CD spectroscopy is an established and valuable technique for examining protein structure, dynamics and folding. Because of its ability to sensitively detect conformational changes, it has important potential for drug discovery, enabling screening for ligand and drug...
Articles
Biochem Soc Trans (2002) 30 (6): 1116–1119.
Published: 01 November 2002
... hairpin ribozyme has been established by crystallography, and is well supported by biochemical and biophysical evidence that has identified conformational changes and key nucleotides required for catalysis. Analogous work is under way to establish the active structure of the hammerhead ribozyme. 1...
Articles
Biochem Soc Trans (2001) 29 (4): 571–577.
Published: 01 August 2001
...J. Li; D. J. Derbyshire; B. Promdonkoy; D. J. Ellar Crystal structures combined with biochemical data show that the δ-endotoxins from Bacillus thuringiensis are structurally poised towards large-scale, irreversible conformational changes that transform them from the soluble protein bound at the...