... have focused on conjugating multiple Nb clones — of identical or unique antigen cognates — together. In vivo and in vitro approaches, including flexible linkers, antibody domains, self-assembling coiled coils, chemical conjugation, and self-clustering hydrophobic sequences, have been employed...

... Medical Art. cancer conjugation drug delivery nanomedicine surface functionalisation targeted therapeutics Cancer is one of the most significant global health burdens and the leading cause of mortality worldwide. Despite notable improvements in cancer treatment, one of the most...

... conjugation, which it still remains as a major issue due to the small number of SUMO E3 ligases discovered so far, in contrast with the large number of SUMO conjugated proteins in the cell. © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 conjugation...

...Dennis W. Grogan HR (homologous recombination) is expected to play important roles in the molecular biology and genetics of archaea, but, so far, few functional properties of archaeal HR have been measured in vivo . In the extreme thermoacidophile Sulfolobus acidocaldarius , a conjugational...

... that SUMO (small ubiquitin-related modifier) conjugation/deconjugation equilibrium is affected by various environmental stresses, including osmotic, hypoxic, heat, oxidative and genotoxic stresses. This regulation occurs either at the level of individual targets, through an interplay between stress-induced...