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Keywords: contractility
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Biochem Soc Trans (2004) 32 (2): 383–386.
Published: 01 April 2004
... in the heart, but the deletion of its expression in mice causes remarkable phenotypes. Indeed, the lack of PI3Kγ does not modify heart rate and blood pressure, but does increase contractility, particularly in response to stimuli that enhance cardiac contractile force, such as catecholamines. Consistently...