...Johan Ø. Ipsen; Magnus Hallas-Møller; Søren Brander; Leila Lo Leggio; Katja S. Johansen Lytic polysaccharide monooxygenases (LPMOs) are mononuclear copper enzymes that catalyse the oxidative cleavage of glycosidic bonds. They are characterised by two histidine residues that coordinate copper...

...Katja S. Johansen The recent discovery of copper-dependent lytic polysaccharide mono-oxygenases (LPMOs) has opened up a vast area of research covering several fields of application. The biotech company Novozymes A/S holds patents on the use of these enzymes for the conversion of steam-pre-treated...

...Sarah L. Hands; Robert Mason; M. Umar Sajjad; Flaviano Giorgini; Andreas Wyttenbach HD (Huntington's disease) is caused by a polyQ (polyglutamine) expansion in the huntingtin protein, which leads to protein misfolding and aggregation of this protein. Abnormal copper accumulation in the HD brain...

... in fostering bioinorganic chemistry in the U.K. and the impact that it has had internationally. 1 email [email protected] 15 9 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 Centre for Metalloprotein Spectroscopy and Biology (CMSB) copper cytochrome c...

.... Maundrell K. Soto C. Is loss of function of the prion protein the cause of prion disorders? Trends Mol. Med. 2003 9 237 243 2 Vassallo N. Herms J. Cellular prion protein function in copper homeostasis and redox signalling at the synapse J. Neurochem. 2003 86 538 544...

...Svetlana Lutsenko Wilson's disease is a severe human disorder of copper homoeostasis. The disease is associated with various mutations in the ATP7B gene that encodes a copper-transporting ATPase, and a massive accumulation of copper in the liver and several other tissues. The most frequent disease...

...Jack T. Rogers; Ashley I. Bush; Hyan-Hee Cho; Deborah H. Smith; Andrew M. Thomson; Avi L. Friedlich; Debomoy K. Lahiri; Peter J. Leedman; Xudong Huang; Catherine M. Cahill The essential metals iron, zinc and copper deposit near the Aβ (amyloid β-peptide) plaques in the brain cortex of AD...

.... The affinity and number of Cu 2+ -binding sites support the suggestion that PrP could act as an antioxidant by binding potentially harmful Cu 2+ ions and sacrificially quenching of free radicals generated as a result of copper redox cycling. Finally, the effect of Cu 2+ on the prion structure and misassembly...

... normal circumstances. In developed countries, this applies mainly to micronutrients. Even now, iron deficiency is a common disorder, especially in pregnancy. Similarly, copper intake in the U.K. population is rarely above adequate levels. It is now becoming clear that nutrient deficiencies during...

... trimer from Methylococcus capsulatus (Bath) Biochemistry 2005 44 10954 10965 5 Murrell J.C. McDonald I.R. Gilbert B. Regulation of expression of methane monooxygenases by copper ions Trends Microbiol. 2000 8 221 225 6 Murray L.J. Lippard S.J. Substrate...

... in treating age-related human diseases. Nevertheless, depending on the concentration of the phytoalexin and the cell type, it has also been shown that resveratrol can exhibit pro-oxidant properties, leading to oxidative breakage of cellular DNA in the presence of transition metal ions such as copper. Recently...

...-cleaving enzyme 1)] and the γ-secretase complex. There is a clear link between APP processing and copper homoeostasis in the brain. APP binds copper and zinc in the extracellular domain and Aβ also binds copper, zinc and iron. We have found that a 24-residue peptide corresponding to the C-terminal domain...

...S.J. Firbank; M. Rogers; R. Hurtado-Guerrero; D.M. Dooley; M.A. Halcrow; S.E.V. Phillips; P.F. Knowles; M.J. McPherson Galactose oxidase (GO; EC 1.1.3.9) is a monomeric 68 kDa enzyme that contains a single copper and an amino acid-derived cofactor. The mechanism of this radical enzyme has been...

...S. M. Vanderwerf; S. Lutsenko The Wilson's disease protein (WNDP), a copper transporter, is a crucial mediator of copper homoeostasis in mammalian cells. We recently found that changes in copper concentration regulate the phosphorylation level of WNDP. WNDP phosphorylation was observed in several...

..., overload of some trace elements, including copper and iron, has been demonstrated to result in adverse effects. However, under normal physiological conditions, such overloads are unlikely to occur. 1 e-mail: [email protected] 8 11 2000 © 2001 Biochemical Society 2001...