... interactions to modify the appropriate substrates and avoid cross-talk among different pathways. In the past 10 years, researchers have discovered and investigated how loss of specific interactions and subcellular targeting for the protein kinase A catalytic subunit (PKAc) lead to cortisol-producing adenomas...

... and, in combination with arterio-venous (AV) sampling, rates of production by specific tissues have been quantified. This has allowed the contribution of liver, adipose, muscle and brain to cortisol production in metabolic disease and hence prioritized drug targets. Most recently MS imaging in combination...

... the suffering of the next generation. 1 email [email protected] 15 10 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 cortisol depression epigenetics hypothalamic–pituitary–adrenal axis intergenerational transmission maternal care pregnancy...