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Keywords: cryo-electron microscopy
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Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2025) BST20253059.
Published: 04 July 2025
... regulate kinase activity and what role PIP 3 plays in pathway activation. A specific focus is on the integration of experimental data derived from X-ray crystallography, cryo-electron microscopy, and hydrogen deuterium exchange mass spectrometry along with recent advances in artifical intelligence enabled...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (6): 2415–2425.
Published: 06 December 2024
... of Max Planck Digital Library in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with MPDL. cell biology cryo-electron microscopy FIB lift-out molecular ultrastructure In the past decade, cryo-electron...
Articles
CryoEM grid preparation: a closer look at advancements and impact of preparation mode and new approaches
Open Access
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (3): 1529–1537.
Published: 12 June 2024
...Isobel J. Hirst; William J.R. Thomas; Rhiannon A. Davies; Stephen P. Muench Sample preparation can present a significant hurdle within single particle cryo-electron microscopy (cryoEM), resulting in issues with reproducibility, data quality or an inability to visualise the sample. There are several...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (4): 1533–1543.
Published: 10 August 2023
... Attribution License 4.0 (CC BY) . Open access for this article was enabled by the participation of University of Florida in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with Individual. cannabinoids cryo-electron...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (4): 1505–1520.
Published: 10 August 2023
... of Medicine in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society. cryo-electron microscopy crystallography kinesin microtubule molecular motors tubulin Kinesins are a superfamily of motor proteins that drive a variety of essential cell...
Includes: Supplementary data
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (3): 1225–1233.
Published: 04 May 2023
... BY) . Open access for this article was enabled by the participation of the University of Geneva in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with Individual. cancer cell cycle cryo-electron microscopy enzyme...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (2): 855–869.
Published: 21 April 2023
... article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . caveolae caveolins cell membranes cryo-electron microscopy membrane proteins protein structure Nanoscale flask-shaped...
Articles
Deciphering the molecular mechanisms of actin cytoskeleton regulation in cell migration using cryo-EM
Open Access
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 87–99.
Published: 25 January 2023
... insights into how geometry and ABPs regulate the actin cytoskeleton limits our understanding of the molecular mechanisms that define actin cytoskeleton remodeling and, in turn, impact emerging cell migration characteristics. With the advent of cryo-electron microscopy (cryo-EM) and advanced computational...
Articles
Structural analysis of mycobacterial electron transport chain complexes by cryoEM
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 183–193.
Published: 20 January 2023
... an additional α-helix that could interfere with the dimerization interface inferred from other NDH-2 structures ( Figure 2C , black circles ). cryo-electron microscopy electron transport chain membrane proteins Mycobacterium tuberculosis protein structure ETC complex II (CII) oxidizes...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (5): 1403–1414.
Published: 05 October 2022
... by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cryo-electron microscopy molecular chaperones molecular mechanisms protein conformation All organisms depend on properly folded and functioning proteins...
Articles
Exploring cryo-electron microscopy with molecular dynamics
Available to PurchaseJohn W. Vant, Daipayan Sarkar, Jonathan Nguyen, Alexander T. Baker, Josh V. Vermaas, Abhishek Singharoy
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 569–581.
Published: 25 February 2022
...John W. Vant; Daipayan Sarkar; Jonathan Nguyen; Alexander T. Baker; Josh V. Vermaas; Abhishek Singharoy Single particle analysis cryo-electron microscopy (EM) and molecular dynamics (MD) have been complimentary methods since cryo-EM was first applied to the field of structural biology...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 459–22W.
Published: 07 February 2022
... have been described: contractile tails of Myoviridae -like phages; short non-contractile tails of Podoviridae -like phages; and long and flexible non-contractile tails of Siphoviridae -like phages. While early cryo-electron microscopy (cryo-EM) work elucidated the organisation of the syringe-like...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (6): 2711–2726.
Published: 02 December 2021
... invaluable, the ‘resolution revolution’ of cryo-electron microscopy has transformed our structural investigations, enabling large, dynamic and often transient transcription complexes to be resolved that in many cases had resisted crystallisation. In this review, we highlight the impact cryo-electron...
Articles
Structural insights into the interactions of Polycomb Repressive Complex 2 with chromatin
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (6): 2639–2653.
Published: 08 November 2021
... of the Biochemical Society 2021 chromatin cryo-electron microscopy epigenetics eukaryotic gene expression transcription Eukaryotic cells pack their DNA (∼6 billion bases) into the small volume of the nucleus (1 × 10 2 –1 × 10 5 µm 3 ) by organizing their DNA into complex but defined structures...
Articles
Conquer by cryo-EM without physically dividing
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (5): 2287–2298.
Published: 28 October 2021
...: Robert M. Glaeser ( [email protected] ) 6 9 2021 29 9 2021 5 10 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 cryo-electron microscopy divide and conquer structure determination The development of the mask...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (5): 2345–2355.
Published: 28 September 2021
... Laboratory of Molecular Biology in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with JISC. cryo-electron microscopy crystallography G-protein-coupled receptors G protein-coupled receptors (GPCRs) are the largest...
Articles
Biological insights from SMA-extracted proteins
Open Access
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (3): 1349–1359.
Published: 10 June 2021
... understanding of the mechanism of proteins such as YnaI and the glycine receptor [ 34 , 46 ]. cryo-electron microscopy membrane proteins protein complexes protein–lipid interactions SMALP Membrane proteins carry out a wide range of critical functions and are key targets for drug discovery [ 1...
Articles
Unveiling the cryo-EM structure of retromer
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (5): 2261–2272.
Published: 14 October 2020
... biology, but recent advances in cryo-electron microscopy and cryo-electron tomography have further uncovered exciting new snapshots of reconstituted retromer structures. These new structures reveal retromer assembles into an arch-shaped scaffold and suggest the scaffold may be flexible and adaptable...
Articles
Caught in the act: structural dynamics of replication origin activation and fork progression
Open Access
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (3): 1057–1066.
Published: 05 May 2020
... Society under a transformative agreement with JISC. biochemistry cryo-electron microscopy DNA replication in silico reconstitution single molecule Accurate transfer of genetic information from parental to daughter cells requires that chromosome replication is finely tuned, so that DNA...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (1): 37–45.
Published: 15 January 2019
...-subunit position at one end of the helix, through the F-subunit position and on to the A-subunit position at the other end of the helix. AAA proteins cryo-electron microscopy endosomal sorting protein disassembly protein structure E ndosomal S orting C omplex R equired for T...
Articles
Structural studies of the spliceosome: past, present and future perspectives
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (6): 1407–1422.
Published: 12 November 2018
...-resolution structural information that was mostly limited to individual proteins and smaller sub-complexes. Recent developments in the field of cryo-electron microscopy allowed the visualisation of fully assembled yeast and human spliceosomes, providing unprecedented insights into substrate recognition...
Articles
In Collection
Awards
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (4): 807–816.
Published: 22 June 2018
... , 22 , 23 ]. The milled specimen is then transferred to the cryo-TEM for data collection. Recent developments in correlative light and cryo-electron microscopy for FIB-milled specimens allow specific cellular processes to be targeted for tomography [ 24 ]. For specimens thicker than several microns...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2017) 45 (6): 1263–1269.
Published: 03 November 2017
... 2017 © 2017 The Author(s) 2017 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cowpea mosaic virus cryo-electron microscopy mutagenesis transient...
Articles
Structure determination of transient transcription complexes
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (4): 1177–1182.
Published: 15 August 2016
...-Humboldt Foundation; the Volkswagen Foundation; and the Jung Foundation. cryo-EM cryo-electron microscopy NTP nucleoside triphosphate Pol polymerase ...
Articles
Ribosomal acrobatics in post-transcriptional control
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (4): 677–683.
Published: 22 July 2008
...Robert J.C. Gilbert; Ian Brierley; John E.G. McCarthy High-resolution structures have given an extremely detailed view of aspects of ribosomes, including some near-functional states. Here, we review the importance of cryo-electron microscopy, among other techniques, in giving an understanding...
Articles
The life and death of translation elongation factor 2
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (1): 1–6.
Published: 20 January 2006
... Society 2006 ADP-ribosylation cryo-electron microscopy diphthamide diphtheria toxin elongation factor 2 (EF2) exotoxin A In the elongation cycle of protein synthesis, elongation factor 1A delivers aminoacylated tRNA to the ribosomal A-site, whereafter the peptidyl transferase centre...
