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Keywords: crystallography
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Articles
Biochem Soc Trans (2024) 52 (6): 2297–2306.
Published: 07 November 2024
..., production of key recombinant enzymes from Arabidopsis (AtCKX2) and maize (ZmCKX1 and ZmCKX4a), development of screening bioassays and progress in X-ray crystallography and synthetic organic chemistry led to extensive progress in the development of these compounds. Currently, the most suitable CKX inhibitors...
Articles
Biochem Soc Trans (2024) 52 (4): 1673–1694.
Published: 03 July 2024
... 6 2024 © 2024 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2024 androgen insensitivity syndrome androgen receptor crystallography post translational modification prostate cancer spinal and bulbar muscular atrophy In a similar manner...
Articles
Biochem Soc Trans (2023) 51 (4): 1533–1543.
Published: 10 August 2023
... mechanism of cannabinoid receptors CB1 and CB2 and aid in the development of future therapeutics. cannabinoids cryo-electron microscopy crystallography G-protein-coupled receptors Human endocannabinoid signaling is primarily mediated by the class A G protein-coupled receptors (GPCRs) CB1...
Articles
Biochem Soc Trans (2023) 51 (4): 1505–1520.
Published: 10 August 2023
... to a more open conformation when unbound ( Figure 1e , columns 5 and 11 vs column 10). cryo-electron microscopy crystallography kinesin microtubule molecular motors tubulin Kinesins are a superfamily of motor proteins that drive a variety of essential cell processes, such as organelle...
Includes: Supplementary data
Articles
Biochem Soc Trans (2022) 50 (3): 1091–1103.
Published: 06 May 2022
... of knowledge of protein–protein and protein–lipid interactions governing the apoptotic function of BAK and BAX, as determined through X-ray crystallography and NMR spectroscopy studies. BAK and BAX are dormant, globular α-helical proteins that participate in protein–protein interactions with other pro-death...
Includes: Supplementary data
Articles
Biochem Soc Trans (2022) 50 (2): 877–893.
Published: 31 March 2022
... inhibitors bound in cyt bc complexes resolved by X-ray crystallography and cryo-EM structures. Although the Q i site architecture of cyt bc 1 complex and cyt bcc complex differs considerably, quinone molecules were resolved at the respective Q i sites in very similar distance to haem b H . In contrast, more...
Articles
Biochem Soc Trans (2021) 49 (5): 2345–2355.
Published: 28 September 2021
... in the structural biology of GPCRs as currently only about one quarter of human non-odorant receptors have had their structure determined. Initially, all the structures were determined by X-ray crystallography, but recent advances in electron cryo-microscopy (cryo-EM) now make GPCRs tractable targets for single...
Articles
Biochem Soc Trans (2020) 48 (6): 2505–2524.
Published: 10 November 2020
... biology toolbox. Considered as one of the pillars of structural biology, X-ray crystallography has been the most successful method for solving three-dimensional protein structures at atomic level to date. It is however limited by the success in obtaining well-ordered protein crystals that diffract at high...
Articles
Biochem Soc Trans (2020) 48 (4): 1765–1780.
Published: 29 July 2020
... for structure-based drug design efforts targeting canonical Wnt signalling. beta-catenin cancer crystallography frizzled glycogen synthase kinase Wnt proteins Notum is an extracellular deacetylase that removes O -lipidation from Wnt proteins, thus deactivating them. The structural biology...
Articles
Biochem Soc Trans (2020) 48 (4): 1661–1673.
Published: 17 July 2020
... Press Limited on behalf of the Biochemical Society 2020 binder proteins crystallography high-throughput screening recombinant proteins X-ray crystallography has been essential to the determination of the atomic structure of proteins for more than 60 years. Even with recent advances...
Articles
Biochem Soc Trans (2020) 48 (3): 1255–1268.
Published: 29 June 2020
... on behalf of the Biochemical Society 2020 cell binding crystallography galectin-8 glycan array glycan specificity sialylation Synthesized in the cytosol and with a still unknown non-classical secretion pathway, galectins display an army of intracellular and extracellular functions [ 7 , 8...
Includes: Supplementary data
Articles
Articles
Biochem Soc Trans (2019) 47 (2): 541–557.
Published: 05 March 2019
... 2019 crystallography fibrinolysis protease inhibitor Plasminogen (Plg) is the zymogen form of the serine protease plasmin (Plm) which is well known for its fibrinolytic function ( Figure 1 ) together with many other indispensable roles such as cell migration [ 1 ], wound healing [ 2 , 3...
Includes: Supplementary data
Articles
Biochem Soc Trans (2017) 45 (3): 709–717.
Published: 15 June 2017
.../disordered [ 9 , 23 , 25 ]. aurora kinases crystallography intrinsically disordered proteins NMR spectroscopy Myc proteins are transcription factors that markedly alter gene expression through both activation and repression [ 1 – 3 ]. The three Myc protein family members in humans (c-Myc, N...
Articles
Biochem Soc Trans (2016) 44 (6): 1659–1666.
Published: 02 December 2016
... crystallography Gram-positive bacteria type IV pili The basic architecture of type IV pili is used for a wide variety of functions including secretion [ 33 ], DNA uptake [ 34 ], surface motility [ 14 ], eukaryotic cell adhesion [ 10 ], microcolony formation [ 35 ], and even electrical conductance [ 36...
Articles
Biochem Soc Trans (2004) 32 (6): 904–909.
Published: 26 October 2004
... for therapeutic application. 1 email [email protected] 28 6 2004 © 2004 The Biochemical Society 2004 chromatin regulation crystallography enzymology histone deacetylase NAD + silent information regulator-2 (Sir2) The enzymes that mediate post-translational...
Articles
Biochem Soc Trans (2004) 32 (1): 17–20.
Published: 01 February 2004
... crystallography inhibitor matrix metalloprotease (MMP) optimization selectivity structure Abbreviation used: MMP, matrix metalloprotease. Design of Inhibitors for Proteolytic Cascades 17 Matrix metalloprotease inhibitors: design from structure N. Borkakoti1 Chemical Technologies, Roche Products...
Articles
Biochem Soc Trans (2003) 31 (3): 537–542.
Published: 01 June 2003
... 2003 16 December 2002 © 2003 Biochemical Society 2003 cytidylyltranferase enzyme manganese synthase X-ray crystallography zinc Abbreviations used: IPP, isopentenyl pyrophosphate; DMAPP, dimethylallyl pyrophosphate; DOXP, 1-deoxy-d-xylulose 5-phosphate; MEP, 2C...
Articles
Biochem Soc Trans (2000) 28 (6): 601–607.
Published: 01 December 2000
.... The structures of the Arabidopsis thaliana KAS family are compared. 1 To whom correspondence should be addressed (e-mail [email protected] ) 26 6 2000 © 2000 Biochemical Society 2000 Claisen condensation crystallography fatty acid synthase in vitro mutagenesis thiolase fold...