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Keywords: cystic fibrosis transmembrane conductance regulator (CFTR)
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Articles

Learning from each other: ABC transporter regulation by protein phosphorylation in plant and mammalian systems

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Bibek Aryal, Christophe Laurent, Markus Geisler
Journal: Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (5): 966–974.
https://doi.org/10.1042/BST20150128
Published: 09 October 2015
... events of human cystic fibrosis transmembrane conductance regulator (CFTR) and ABCB1 from the model plant Arabidopsis reveals a surprisingly high degree of similarity. Both physically interact with orthologues of the FK506-binding proteins that chaperon both transporters to the plasma membrane...
View articletitled, Learning from each other: ABC transporter regulation by protein phosphorylation in plant and mammalian systems
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Articles

Exploiting species differences to understand the CFTR Cl − channel

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Samuel J. Bose, Toby S. Scott-Ward, Zhiwei Cai, David N. Sheppard
Journal: Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (5): 975–982.
https://doi.org/10.1042/BST20150129
Published: 09 October 2015
...Samuel J. Bose; Toby S. Scott-Ward; Zhiwei Cai; David N. Sheppard The anion channel cystic fibrosis transmembrane conductance regulator (CFTR) is a unique ATP-binding cassette (ABC) transporter. CFTR plays a pivotal role in transepithelial ion transport as its dysfunction in the genetic disease...
View articletitled, Exploiting species differences to understand the CFTR Cl − channel
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Includes: Supplementary data
Articles

Intestinal inflammation and the enterocyte transportome

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Isabel Romero-Calvo, Cristina Mascaraque, Antonio Zarzuelo, María Dolores Suárez, Olga Martínez-Augustin, Fermín Sánchez de Medina
Journal: Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (4): 1096–1101.
https://doi.org/10.1042/BST0391096
Published: 20 July 2011
.... Steinbrecher K.A. Rothenberg M.E. Shroyer N.F. Matthaei K.I. Interleukin-13 (IL-13)/IL-13 receptor α1 (IL-13Rα1) signaling regulates intestinal epithelial cystic fibrosis transmembrane conductance regulator (CFTR) channel-dependent Cl− secretion J. Biol. Chem. 2011 286 13357 13369...
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Articles

Novel regulatory mechanisms for the CFTR gene

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Christopher J. Ott, Neil P. Blackledge, Shih-Hsing Leir, Ann Harris
Journal: Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (4): 843–848.
https://doi.org/10.1042/BST0370843
Published: 22 July 2009
... (3C) cortactin-binding protein 2 (CTTNBP2) cystic fibrosis transmembrane conductance regulator (CFTR) DNase I-hypersensitive site (DHS) The CFTR (cystic fibrosis transmembrane conductance regulator) gene encompasses 189 kb at chromosome 7q31.2 [ 1 ]. CFTR is flanked on the 5′ side...
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Articles

Crystallographic and single-particle analyses of native- and nucleotide-bound forms of the cystic fibrosis transmembrane conductance regulator (CFTR) protein

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N.H. Awayn, M.F. Rosenberg, A.B. Kamis, L.A. Aleksandrov, J.R. Riordan, R.C. Ford
Journal: Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (5): 996–999.
https://doi.org/10.1042/BST0330996
Published: 26 October 2005
... of the protein was observed in the quiescent (nucleotide-free) state. © 2005 The Biochemical Society 2005 ATP-binding cassette (ABC) cystic fibrosis transmembrane conductance regulator (CFTR) crystallization membrane protein single-particle analysis three-dimensional structure The ABC (ATP...
View articletitled, Crystallographic and single-particle analyses of native- and nucleotide-bound forms of the cystic fibrosis transmembrane conductance regulator (CFTR) protein
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Articles

Control of the CFTR channel's gates

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P. Vergani, C. Basso, M. Mense, A.C. Nairn, D.C. Gadsby
Journal: Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (5): 1003–1007.
https://doi.org/10.1042/BST0331003
Published: 26 October 2005
...-binding cassette protein (ABC protein) cystic fibrosis transmembrane conductance regulator (CFTR) heterodimer single-channel kinetics nucleotide-binding domain Cystic fibrosis is the most common lethal genetic disease in Caucasian populations. It is caused by mutations in the CFTR gene...
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