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Keywords: cytochrome c
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Articles
Biochem Soc Trans (2023) 51 (4): 1611–1619.
Published: 06 July 2023
... by the reduction in molecular oxygen at Complex IV, cytochrome c oxidase (C c O) that is coupled with the proton pumping from the matrix to the inner membrane space. Unlike the ET reactions from Complex I to Complex III, the ET reaction to C c O, mediated by cytochrome c (Cyt c ), is quite specific...
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Biochem Soc Trans (2021) 49 (6): 2903–2915.
Published: 08 November 2021
... in the ‘classical’ apoptosis triggering pathway. Cytoplasmic release of cytochrome c (cyt c ), a mitochondrial electron transporter, is a prominent indicator of such critical step. Therefore, visualizing cyt c efflux in living cells is a convenient approach to address apoptosis triggering and monitor performance...
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Biochem Soc Trans (2014) 42 (1): 47–51.
Published: 23 January 2014
... of a cell to apoptosis. However, once downstream events have resulted in the release of cytochrome c to the cytosol, it is widely considered that cell death is inevitable. Cytochrome c may promote its own release from mitochondria through interactions with the mitochondrial phospholipid cardiolipin...
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Biochem Soc Trans (2013) 41 (1): 118–123.
Published: 29 January 2013
... types, but that the organelle also regulates intracellular signalling through the production of ROS (reactive oxygen species) and initiates apoptosis through the release of cytochrome c [ 1 , 2 ]. Notably, although much is known about the role of mitochondria in metabolically active tissues...
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Biochem Soc Trans (2012) 40 (4): 609–614.
Published: 20 July 2012
... will be highlighted here. On the one hand, TERS measurements on a single mitochondrion are discussed, monitoring the oxidation state of the central iron ion of cytochrome c , leading towards a single protein characterization scheme in a natural environment. On the other hand, a novel approach of single molecule...
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Biochem Soc Trans (2012) 40 (2): 415–418.
Published: 21 March 2012
... their function. This is true, in particular, for electron transfer proteins. These proteins catalyse the transport of electrons from one redox enzyme to another. Well-known examples are Cc (cytochrome c ) and plastocyanin, which shuttle electrons in the respiratory and photosynthetic redox chains respectively...
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Biochem Soc Trans (2011) 39 (5): 1293–1298.
Published: 21 September 2011
... biochemical, molecular and spectroscopic methods. Recently, we have applied ultrafast 2D-IR (two-dimensional IR) spectroscopy to the analysis of NO–protein interactions using Mb (myoglobin) and Cc (cytochrome c ) as model haem proteins. The ultrafast fluctuations of Cc and Mb show marked differences...
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Biochem Soc Trans (2011) 39 (5): 1538–1543.
Published: 21 September 2011
... achievements in the elucidation of the events leading to PCD that occur as a response to yeast treatment with AA (acetic acid). In particular, ROS (reactive oxygen species) generation, cyt c (cytochrome c ) release and mitochondrial function and proteolytic activity will be dealt with as they vary along the AA...
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Biochem Soc Trans (2008) 36 (6): 1124–1128.
Published: 19 November 2008
...Despoina A.I. Mavridou; Martin Braun; Linda Thöny-Meyer; Julie M. Stevens; Stuart J. Ferguson The CXXCH motif is usually recognized in the bacterial periplasm as a haem attachment site in apocytochromes c . There is evidence that the Escherichia coli Ccm (cytochrome c maturation) system recognizes...
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Biochem Soc Trans (2006) 34 (6): 1334–1340.
Published: 25 October 2006
... programmed cell death is prominent. 1 To whom correspondence should be addressed (email [email protected] ). 19 7 2006 © 2006 The Biochemical Society 2006 apoptosis inducing factor (AIF) Bid caspase cytochrome c mitochondrion programmed cell death...
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Biochem Soc Trans (2006) 34 (6): 1186–1191.
Published: 25 October 2006
... or variant POR and characterized their activities with cytochrome c and P450c17 assays. We have recently completed an extensive study of the range of POR mutations and characterized the mutants/polymorphisms A112V, T139A, M260V, Y456H, A500V, G536R, L562P, R613X, V628I and F643del from sequencing of patient...
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Biochem Soc Trans (2006) 34 (6): 1283–1286.
Published: 25 October 2006
... permeabilization of the outer mitochondrial membrane by forming an inhibitory complex with a protective Bcl-2 family protein, resulting in cytochrome c release in several cell line systems. However, it is unclear how the mitochondrial p53 pathway mediates neuronal apoptosis after cerebral ischaemia. We examined...
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Biochem Soc Trans (2005) 33 (4): 792–795.
Published: 01 August 2005
... and in vivo studies have provided insight into the function of this protein and into the overall process of cytochrome c biogenesis. It has been suggested that radical chemistry may be involved in the function of CcmE. The involvement of a radical has been proposed in the attachment of His 130 to the β...
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Biochem Soc Trans (2005) 33 (4): 724–727.
Published: 01 August 2005
... 2005 apoptosis carbonic anhydrase cell cycle coxib cytochrome c NAG-1 (non-steroidal anti-inflammatory drug-activated gene) While COX-2 is undetectable in most tissues in the absence of stimulation, it is induced in cells such as monocytes, macrophages, neutrophils...
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Biochem Soc Trans (2005) 33 (4): 829–831.
Published: 01 August 2005
...J. Salje; B. Ludwig; O.-M.H. Richter Despite the existence of several three-dimensional structures of cytochrome c oxidases, a detailed understanding of pathways involved in proton movements through the complex remains largely elusive. Next to the two well-established pathways (termed D and K...
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Biochem Soc Trans (2005) 33 (1): 149–151.
Published: 01 February 2005
... cytochrome c maturation in Bacillus subtilis with particular emphasis on the crystal structures of ResA. 1 To whom correspondence should be addressed (email [email protected] ). 15 9 2004 © 2005 The Biochemical Society 2005 cytochrome c disulphide Gram-positive haem...
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Biochem Soc Trans (2004) 32 (6): 1078–1080.
Published: 26 October 2004
... in cell and mitochondrial membrane. 1 To whom correspondence should be addressed (email [email protected] ). 23 7 2004 © 2004 The Biochemical Society 2004 apoptosis cyclo-oxygenase cytochrome c mitochondrion prostaglandin receptor Apoptosis is a distinct...
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Biochem Soc Trans (2003) 31 (6): 1312–1315.
Published: 01 December 2003
...M.O. Pereverzev; T.V. Vygodina; A.A. Konstantinov; V.P. Skulachev Generation of Δψ (membrane potential) by cytochrome oxidase proteoliposomes oxidizing superoxide-reduced cytochrome c has been demonstrated. XO+HX (xanthine oxidase and hypoxanthine) were used to produce superoxide. It was found...
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Biochem Soc Trans (2003) 31 (3): 502–505.
Published: 01 June 2003
...; the resultant domain mobility leads to activation. Enzyme Mechanism – A Structural Perspective, a Biochemical Society Focused Meeting held at St. Andrews University, 12–14 January 2003 2 January 2003 © 2003 Biochemical Society 2003 autoinhibition calmodulin cytochrome c electron...
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Biochem Soc Trans (2002) 30 (4): 638–642.
Published: 01 August 2002
...-mail [email protected] ) 1 Present address: Department of Biochemistry, University of Oxford, Oxford OX1 3QU, U.K. 21 3 2002 © 2002 Biochemical Society 2002 cytochrome c electron transfer SoxAX complex Biochemical Society Transactions (2002) Volume 30, part 4 39 40 41 42 43...
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Biochem Soc Trans (2000) 28 (2): 56–61.
Published: 01 February 2000
... is required for the damage-induced mitochondrial pathway. This is suggested by the finding that the depletion of glutathione, a common event in damage-induced apoptosis, is necessary and sufficient to induce cytochrome c release, the key event of this pathway. A model is proposed with GSH efflux...
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Biochem Soc Trans (2000) 28 (2): 164–169.
Published: 01 February 2000
... as a prerequisite for the action of ADP shuttles via creatine kinases or adenylate kinases. If the outer membrane becomes leaky, cytochrome c and apoptosis-inducing factor can be released, leading to apoptosis, and as a bioenergetic consequence the cytosolic phosphorylation potential decreases. Leaky outer...
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Biochem Soc Trans (2000) 28 (2): 170–177.
Published: 01 February 2000
... MPTP opening directly. Recovery of hearts correlates with subsequent closure, and agents that prevent opening or enhance closure protect from injury. Transient MPTP opening may also be involved in apoptosis by initially causing swelling and rupture of the outer membrane to release cytochrome c (cyt c...