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Keywords: cytochrome c
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Articles
Biochem Soc Trans (2023) 51 (4): 1611–1619.
Published: 06 July 2023
... by the reduction in molecular oxygen at Complex IV, cytochrome c oxidase (C c O) that is coupled with the proton pumping from the matrix to the inner membrane space. Unlike the ET reactions from Complex I to Complex III, the ET reaction to C c O, mediated by cytochrome c (Cyt c ), is quite specific...
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Articles
Biochem Soc Trans (2021) 49 (6): 2903–2915.
Published: 08 November 2021
... in the ‘classical’ apoptosis triggering pathway. Cytoplasmic release of cytochrome c (cyt c ), a mitochondrial electron transporter, is a prominent indicator of such critical step. Therefore, visualizing cyt c efflux in living cells is a convenient approach to address apoptosis triggering and monitor performance...
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Biochem Soc Trans (2014) 42 (1): 47–51.
Published: 23 January 2014
... of a cell to apoptosis. However, once downstream events have resulted in the release of cytochrome c to the cytosol, it is widely considered that cell death is inevitable. Cytochrome c may promote its own release from mitochondria through interactions with the mitochondrial phospholipid cardiolipin...
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Biochem Soc Trans (2013) 41 (1): 118–123.
Published: 29 January 2013
... 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 cybrid cytochrome c redox signalling platelet mitochondria The traditional view of the mitochondrion as the ‘powerhouse’ of the cell has greatly evolved over the last few decades. It is now clear...
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Biochem Soc Trans (2012) 40 (4): 609–614.
Published: 20 July 2012
... will be highlighted here. On the one hand, TERS measurements on a single mitochondrion are discussed, monitoring the oxidation state of the central iron ion of cytochrome c , leading towards a single protein characterization scheme in a natural environment. On the other hand, a novel approach of single molecule...
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Biochem Soc Trans (2012) 40 (2): 415–418.
Published: 21 March 2012
.... These proteins catalyse the transport of electrons from one redox enzyme to another. Well-known examples are Cc (cytochrome c ) and plastocyanin, which shuttle electrons in the respiratory and photosynthetic redox chains respectively. The electron flux through these chains is high, to maximize energy conversion...
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Biochem Soc Trans (2011) 39 (5): 1293–1298.
Published: 21 September 2011
... biochemical, molecular and spectroscopic methods. Recently, we have applied ultrafast 2D-IR (two-dimensional IR) spectroscopy to the analysis of NO–protein interactions using Mb (myoglobin) and Cc (cytochrome c ) as model haem proteins. The ultrafast fluctuations of Cc and Mb show marked differences...
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Biochem Soc Trans (2011) 39 (5): 1538–1543.
Published: 21 September 2011
... achievements in the elucidation of the events leading to PCD that occur as a response to yeast treatment with AA (acetic acid). In particular, ROS (reactive oxygen species) generation, cyt c (cytochrome c ) release and mitochondrial function and proteolytic activity will be dealt with as they vary along the AA...
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Biochem Soc Trans (2008) 36 (6): 1124–1128.
Published: 19 November 2008
...Despoina A.I. Mavridou; Martin Braun; Linda Thöny-Meyer; Julie M. Stevens; Stuart J. Ferguson The CXXCH motif is usually recognized in the bacterial periplasm as a haem attachment site in apocytochromes c . There is evidence that the Escherichia coli Ccm (cytochrome c maturation) system recognizes...
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Biochem Soc Trans (2006) 34 (6): 1283–1286.
Published: 25 October 2006
... permeabilization of the outer mitochondrial membrane by forming an inhibitory complex with a protective Bcl-2 family protein, resulting in cytochrome c release in several cell line systems. However, it is unclear how the mitochondrial p53 pathway mediates neuronal apoptosis after cerebral ischaemia. We examined...
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Biochem Soc Trans (2006) 34 (6): 1334–1340.
Published: 25 October 2006
... programmed cell death is prominent. 1 To whom correspondence should be addressed (email carsten.culmsee@cup.uni-muenchen.de ). 19 7 2006 © 2006 The Biochemical Society 2006 apoptosis inducing factor (AIF) Bid caspase cytochrome c mitochondrion programmed cell death...
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Biochem Soc Trans (2006) 34 (6): 1186–1191.
Published: 25 October 2006
... or variant POR and characterized their activities with cytochrome c and P450c17 assays. We have recently completed an extensive study of the range of POR mutations and characterized the mutants/polymorphisms A112V, T139A, M260V, Y456H, A500V, G536R, L562P, R613X, V628I and F643del from sequencing of patient...
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Biochem Soc Trans (2005) 33 (4): 724–727.
Published: 01 August 2005
... Society 2005 apoptosis carbonic anhydrase cell cycle coxib cytochrome c NAG-1 (non-steroidal anti-inflammatory drug-activated gene) Cancer prevention, at present a better option than cancer treatment, is entering an era when it appears to be a realistic possibility. The seminal...
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Biochem Soc Trans (2005) 33 (4): 829–831.
Published: 01 August 2005
...J. Salje; B. Ludwig; O.-M.H. Richter Despite the existence of several three-dimensional structures of cytochrome c oxidases, a detailed understanding of pathways involved in proton movements through the complex remains largely elusive. Next to the two well-established pathways (termed D and K...
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Biochem Soc Trans (2005) 33 (4): 792–795.
Published: 01 August 2005
... and in vivo studies have provided insight into the function of this protein and into the overall process of cytochrome c biogenesis. © 2005 The Biochemical Society 2005 CcmE chaperone cofactor covalent bond cytochrome c haem 1 To whom correspondence should be addressed (email...
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Biochem Soc Trans (2005) 33 (1): 149–151.
Published: 01 February 2005
... cytochrome c maturation in Bacillus subtilis with particular emphasis on the crystal structures of ResA. Because of the intimate nature of the thiol–disulphide redox chemistry (which involves the formation of a transient disulphide bond between redox partners) and short distance between the cleft...
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Biochem Soc Trans (2004) 32 (6): 1078–1080.
Published: 26 October 2004
... in cell and mitochondrial membrane. 1 To whom correspondence should be addressed (email paul@mail.ncku.edu.tw ). 23 7 2004 © 2004 The Biochemical Society 2004 apoptosis cyclo-oxygenase cytochrome c mitochondrion prostaglandin receptor Research Colloquia: Research...
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Biochem Soc Trans (2003) 31 (6): 1312–1315.
Published: 01 December 2003
...M.O. Pereverzev; T.V. Vygodina; A.A. Konstantinov; V.P. Skulachev Generation of Δψ (membrane potential) by cytochrome oxidase proteoliposomes oxidizing superoxide-reduced cytochrome c has been demonstrated. XO+HX (xanthine oxidase and hypoxanthine) were used to produce superoxide. It was found...
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Biochem Soc Trans (2003) 31 (3): 502–505.
Published: 01 June 2003
...; the resultant domain mobility leads to activation. autoinhibition calmodulin cytochrome c electron transfer nitric oxide reductase domain Abbreviations used: NOS, nitric oxide synthase; nNOS, iNOS, eNOS, neuronal, induced and endothelial NOS respectively; nNOSrd, nNOS reductase domain...
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Biochem Soc Trans (2002) 30 (4): 638–642.
Published: 01 August 2002
... haemoproteins where both partners adopt the c -type cytochrome fold. The packing of c -type cytochrome domains both within SoxA and at the interface between the subunits of the complex has been compared with other examples and found to be unique. cytochrome c electron transfer SoxAX complex 2...
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Biochem Soc Trans (2000) 28 (2): 56–61.
Published: 01 February 2000
... is required for the damage-induced mitochondrial pathway. This is suggested by the finding that the depletion of glutathione, a common event in damage-induced apoptosis, is necessary and sufficient to induce cytochrome c release, the key event of this pathway. A model is proposed with GSH efflux...
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Biochem Soc Trans (2000) 28 (2): 164–169.
Published: 01 February 2000
... as a prerequisite for the action of ADP shuttles via creatine kinases or adenylate kinases. If the outer membrane becomes leaky, cytochrome c and apoptosis-inducing factor can be released, leading to apoptosis, and as a bioenergetic consequence the cytosolic phosphorylation potential decreases. Leaky outer...
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Biochem Soc Trans (2000) 28 (2): 170–177.
Published: 01 February 2000
... MPTP opening directly. Recovery of hearts correlates with subsequent closure, and agents that prevent opening or enhance closure protect from injury. Transient MPTP opening may also be involved in apoptosis by initially causing swelling and rupture of the outer membrane to release cytochrome c (cyt c...