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Keywords: cytoskeleton
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Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (4): 1785–1794.
Published: 27 June 2024
... by the participation of University of Cambridge in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with JISC. cytoskeleton Dictyostelium discoideum endocytosis macropinocytosis PIP3 Fourth, often when cups close...
Articles
SPECC1L: a cytoskeletal protein that regulates embryonic tissue dynamics
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (3): 949–958.
Published: 22 June 2023
..., no SPECC1L loss-of-function mutations, associated with any embryonic deficits or lethality, have yet been reported in the literature. © 2023 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2023 cytoskeleton embryogenesis microfilaments microtubule...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (5): 1281–1291.
Published: 25 October 2022
... This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cytoskeleton efferocytosis immune receptors mechanobiology phagocytosis phosphatidylserine In a classical paper...
Articles
Studying actin-induced cell shape changes using Giant Unilamellar Vesicles and reconstituted actin networks
Open Access
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (5): 1527–1539.
Published: 16 September 2022
...Rogério Lopes dos Santos; Clément Campillo Cell shape changes that are fuelled by the dynamics of the actomyosin cytoskeleton control cellular processes such as motility and division. However, the mechanisms of interplay between cell membranes and actomyosin are complicated to decipher...
Articles
Effects of neuronal drebrin on actin dynamics
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (2): 685–692.
Published: 19 March 2021
...Elena E. Grintsevich Drebrin is a key regulator of actin cytoskeleton in neuronal cells which is critical for synaptic plasticity, neuritogenesis, and neuronal migration. It is also known to orchestrate a cross-talk between actin and microtubules. Decreased level of drebrin is a hallmark...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (1): 217–235.
Published: 01 February 2021
... with Portland Press and the Biochemical Society under a transformative agreement with JISC. cytoskeleton phospholipids PKN protein-serine-threonine kinases Rho-associated protein kinases The PRK serine/threonine kinase family comprises three members, PRK1 (also PKN/PKN1/PKNα), PRK2 (PKN2/PKNγ...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (4): 1397–1417.
Published: 17 July 2020
... indirectly reduces the level of cytosolic p110 due to its intrinsic instability and therefore attenuates PI3K signalling ( Figure 4 ). cytoskeleton nuclear functions p85 phosphoinositide 3-kinase receptor trafficking regulatory dimers Analogous to its role in oxidative stress, p85α is also...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (6): 1621–1634.
Published: 12 December 2019
... for cell shape are therefore the elements of the bacterial cytoskeleton, principally FtsZ, MreB, and the penicillin-binding proteins. MreB is particularly relevant in the transition between rod-like and spherical cell shape as it is often (but not always) lost early in the process. Here we will highlight...
Includes: Supplementary data
Articles
The role of LRRK2 in cell signalling
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (1): 197–207.
Published: 21 December 2018
...) RNA–protein complex, inhibiting NFAT signalling, and as part of the β-catenin destruction complex, inhibiting canonical Wnt signalling [ 18 , 24 ]. LRRK2 also associates with the microtubule (MT) cytoskeleton and GSK3β, thereby facilitating tau phosphorylation by GSK3β [ 19 , 21 , 25 ]. In addition...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (6): 1665–1672.
Published: 22 November 2018
...Claire T. Friel; Julie P. Welburn The Kinesin superfamily is a large group of molecular motors that use the turnover of ATP to regulate their interaction with the microtubule cytoskeleton. The coupled relationship between nucleotide turnover and microtubule binding is harnessed in various ways...
Articles
The role of LRRK2 in cytoskeletal dynamics
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (6): 1653–1663.
Published: 22 November 2018
... on a functional cytoskeleton for many homeostatic processes such as local and long-distance vesicle transport, synaptic plasticity, and dendrites/axons growth and remodeling. Here, we will review the available data linking LRRK2 and the cytoskeleton, and discuss how this may be functionally relevant for the well...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (6): 1709–1716.
Published: 02 December 2016
... Attribution License 4.0 (CC BY) . Borg Cdc42 cytoskeleton Rho GTPases septin The Rho GTPase family member Cdc42 regulates a diverse range of cellular functions including cytokinesis, cytoskeletal remodelling and cell polarity [ 1 , 2 ]. Like other Rho family members, Cdc42 cycles between two...
Articles
New nuclear and perinuclear functions of formins
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (6): 1701–1708.
Published: 02 December 2016
... and microtubule dynamics. Not surprisingly, formins are best known as key regulators of the cytoskeleton in a variety of morphogenetic processes. However, mounting evidence implicates several formins in the assembly and organization of actin within and around the nucleus. In addition, actin-independent roles...
Articles
Diaphanous-related formin 1 as a target for tumor therapy
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (5): 1289–1293.
Published: 19 October 2016
...); published by Portland Press Limited on behalf of the Biochemical Society 2016 cytoskeleton tumor cell adhesion vesicle trafficking Metastasis is the leading cause of death in cancer patients [ 1 , 2 ]. The first step of metastasis is considered to be the epithelial-to-mesenchymal transition...
Articles
How myosin organization of the actin cytoskeleton contributes to the cancer phenotype
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (4): 1026–1034.
Published: 15 August 2016
..., at least one class 2 gene and classes 5, 6, 9, 10, 18 and 19. Although the different myosin isoforms all have specific and non-overlapping roles in the cell, in combination they all contribute to the organization of the actin cytoskeleton, and the shape and phenotype of the cell. Over (or under) expression...
Articles
Pushing with actin: from cells to pathogens
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (1): 84–91.
Published: 26 January 2015
... ET, we have shown that baculovirus generates at its rear a fishbone-like array of subsets of branched actin filaments, with an average of only four filaments engaged in pushing at any one time. In both of these studies, the application of ET of negatively stained cytoskeletons for higher filament...
Articles
RNA granules and cytoskeletal links
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 1206–1210.
Published: 11 August 2014
.... SGs and P-bodies are related to NGs (neuronal granules), which are essential in the localization and control of mRNAs in neurons. Importantly, RNA granules are linked to the cytoskeleton, which plays an important role in mediating many of their dynamic properties. In the present review, we discuss how...
Articles
Self-incompatibility in Papaver : advances in integrating the signalling network
Available to PurchaseDeborah J. Eaves, Carlos Flores-Ortiz, Tamanna Haque, Zongcheng Lin, Nianjun Teng, Vernonica E. Franklin-Tong
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (2): 370–376.
Published: 20 March 2014
... transmembrane protein. Interaction of matching pollen and pistil S -determinants results in self-recognition, initiating a Ca 2+ -dependent signalling network in incompatible pollen. This triggers several downstream events, including alterations to the cytoskeleton, phosphorylation of sPPases (soluble inorganic...
Articles
Interactions between Epac1 and ezrin in the control of endothelial barrier function
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (2): 274–278.
Published: 20 March 2014
... protein directly activated by cAMP). The present review outlines the role of Epac1 signalling within the endothelium and, in particular, the role of Epac1 in cytoskeletal dynamics and the control of cell morphology. The actin/cytoskeleton linker ezrin will be described in terms of the growing body...
Articles
Cdc42 regulates polarized growth and cell integrity in fission yeast
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (1): 201–205.
Published: 23 January 2014
...Sergio A. Rincón; Miguel Estravís; Pilar Pérez Polarized cell growth requires a well-orchestrated number of events, namely selection of growth site, organization of cytoskeleton elements and delivery of new material to the growth region. The small Rho GTPase Cdc42 has emerged as a major organizer...
Articles
Formin-based control of the actin cytoskeleton during cytokinesis
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (6): 1750–1754.
Published: 20 November 2013
... 2013 Biochemical Society 2013 actin cytokinesis cytoskeleton formin CR cytokinetic ring DAD diaphanous autoregulatory domain DID diaphanous inhibitory domain F-actin filamentous actin FH formin homology G-actin globular actin SIN septation...
Articles
Microtubules: greater than the sum of the parts
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (6): 1736–1744.
Published: 20 November 2013
...Jonathan L.D. Lawson; Rafael E. Carazo Salas The post-genomic era has produced a variety of new investigation technologies, techniques and approaches that may offer exciting insights into many long-standing questions of scientific research. The microtubule cytoskeleton is a highly conserved system...
Articles
LRRK2 and vesicle trafficking
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (5): 1117–1122.
Published: 19 September 2012
... role of LRRK2 in the regulation of membrane trafficking from vesicle generation to the movement along cytoskeleton and finally to vesicle fusion with cell membrane. PD (Parkinson's disease) is the second most common neurodegenerative disorder after Alzheimer's disease, affecting more than 1 million...
Articles
Insights into LRRK2 function and dysfunction from transgenic and knockout rodent models
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (5): 1080–1085.
Published: 19 September 2012
..., LRRK2 is reported to have modulatory effects upon the cytoskeleton and autophagy, which can also modulate neurite morphology. Therefore whether the alterations in neurite outgrowth are simply secondary events is still unclear. autophagy cytoskeleton dopamine leucine-rich repeat kinase 2...
Articles
Uses of the in vitro endothelial–fibroblast organotypic co-culture assay in angiogenesis research
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1597–1600.
Published: 21 November 2011
..., including protocols for siRNA (small interfering RNA)-based screens, and we discuss appropriate methods for obtaining quantitative data from the assay. angiogenesis cell co-culture cytoskeleton endothelial cell fibroblast Matrigel assay Angiogenesis is the process by which new blood vessels...
Articles
Organelle Biogenesis and Positioning in Plants
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (3): 729–732.
Published: 24 May 2010
... cytoskeleton higher plant nuclear envelope organelle biogenesis organelle positioning Understanding the processes that result in formation of an organelle, whether membranous or membrane-bounded, requires an understanding not only of the molecular constituents of the organelle and of its...
Articles
Mitochondrial fusion, division and positioning in plants
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (3): 789–795.
Published: 24 May 2010
.... Mitochondria are highly motile and movement on the cytoskeleton ensures that the physically discrete organelles come into contact with one another, which allows transient fusion, followed by division of the mitochondrial membranes. This article serves to review our current knowledge of mitochondrial fusion...
Articles
Networking in the endoplasmic reticulum
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (3): 747–753.
Published: 24 May 2010
...’. With latrunculin B treatment, we have investigated the involvement of actin in the elongation and persistency of the tubules. We also show how the cytoskeleton is involved in directional diffusion within the membrane. This observation may lead to an answer to the question of what function this network structure...
Articles
KASH-domain proteins and the cytoskeletal landscapes of the nuclear envelope
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (6): 1368–1372.
Published: 19 November 2008
... (anchorage 1)/SYNE (synaptic nuclear envelope protein) homology]-domain family, which function primarily as exclusive outer nuclear membrane scaffolds that associate with the cytoskeleton, the centrosome and the motor protein apparatus. In the present paper, we propose a novel model, which may explain why...
Articles
Regulation of cell–cell adhesion by the cadherin–catenin complex
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (2): 149–155.
Published: 20 March 2008
... in the organization of the actin cytoskeleton. Although cadherins were thought to bind directly to the actin cytoskeleton through cytoplasmic proteins, termed α- and β-catenin, recent studies with purified proteins indicate that the interaction is not direct, and instead an allosteric switch in α-catenin may mediate...
Articles
F-actin cytoskeletal organization in intervertebral disc health and disease
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (4): 683–685.
Published: 20 July 2007
...S. Li; V.C. Duance; E.J. Blain The cytoskeleton, which in most cell types, including the intervertebral disc described here, comprises microfilaments, microtubules and intermediate filaments, plays important functions in many fundamental cellular events, including cell division, motility, protein...
Articles
Plasmodesmata and intercellular transport of viral RNA
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (1): 142–145.
Published: 22 January 2007
... is correlated with increased accumulation of MP on microtubules, a role of MPB2C in controlling virus movement by tethering the MP to the cytoskeleton has been proposed [ 22 ]. PAPK resides at plasmodesmata and specifically phosphorylates TMV-MP at its C-terminus in vitro [ 23 ]. This finding is consistent...
Articles
Retrograde signalling at the synapse: a role for Wnt proteins
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (6): 1295–1298.
Published: 26 October 2005
... with Wnts, by increasing the size of growth cones and the diameter of axons while decreasing the length of axons. This extensive remodelling is also correlated with the presence of large numbers of dynamic and stable microtubules [ 11 ]. © 2005 The Biochemical Society 2005 cytoskeleton glycogen...
Articles
Relationship between the role of the adenomatous polyposis coli protein in colon cancer and its contribution to cytoskeletal regulation
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (4): 694–697.
Published: 01 August 2005
... the normal maintenance of this tissue: differentiation, migration, proliferation and apoptosis. Indeed, APC is involved in the regulation of β-catenin and it also is an important regulator of the cytoskeleton. Thus mutations in APC lead to the accumulation of β-catenin, which causes changes...
Articles
Mechanisms of integration of cells and extracellular matrices by integrins
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (5): 822–825.
Published: 26 October 2004
... the contractile cytoskeleton to the plasma membrane, but there is also evidence that integrin receptors modulate signalling events that are essential for cellular differentiation. A major challenge is now to integrate work at the atomic, molecular and cellular levels, and obtain holistic insights...
Articles
Interactions between G-protein-coupled receptors and periplakin: a selective means to regulate G-protein activation
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (5): 878–880.
Published: 26 October 2004
... © 2004 The Biochemical Society 2004 cytoskeleton G-protein G-protein-coupled receptor melanin concentrating hormone opioid plakin Although initially considered to exist in isolation as monomers, recent studies have shown that GPCRs (G-protein-coupled receptors) often exist within...
Articles
Control of SCAR activity in Dictyostelium discoideum
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (6): 1113–1114.
Published: 26 October 2004
... 2004 cytoskeleton Dictyostelium motility Nap1 PIR121 suppressor of cAMP receptor (SCAR) Research Colloquia: Research Colloquia at BioScience2004, held at SECC Glasgow, U.K., 18–22 July 2004. Edited by M. Bouvier (Montreal, Canada), G. Milligan (Glasgow, U.K.), V. O'Donnell (Cardiff...
Articles
Cytoskeletal proteins talin and vinculin in integrin-mediated adhesion
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (5): 831–836.
Published: 26 October 2004
... of such junctions, whereas vinculin appears to be important in regulating adhesion dynamics and cell migration. The integrin family of cell adhesion molecules are coupled to the actin cytoskeleton [ 1 ] with the exception of integrin α6β4, which is linked to the intermediate filament network in hemidesmosomes...
Articles
Lysophosphatidic acid: mitogen and motility factor
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (6): 1209–1212.
Published: 01 December 2003
... 2003 Biochemical Society 2003 cytoskeleton lysophosphatidic acid (LPA) motility phospholipase Rho GTPase Tiam1 Abbreviations used: LPA, lysophosphatidic acid; GPCR, G-protein-coupled receptor; PI 3-kinase, phosphoinositide 3-kinase; EGF, epidermal growth factor; PLD, phospholipase...
Articles
Activated M-phase-promoting factor (MPF) is exported from the nucleus of starfish oocytes to increase the sensitivity of the Ins(1,4,5)P3 receptors
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (1): 79–82.
Published: 01 February 2003
... meeting held at University of Liverpool, Liverpool, 4–6 September 2002 6 September 2002 Copyright 2003 Biochemical Society 2003 cytoskeleton nucleus Abbreviations used: ADF; actin depolymerization factor; BAPTA, bis-( o -aminophenoxy)ethane- N,N,N´,N´ -tetra-acetic acid...
Articles
A-kinase-anchoring proteins and cytoskeletal signalling events
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (1): 87–89.
Published: 01 February 2003
...J.D. Scott Targeting of protein kinases and phosphatases to the cytoskeleton enhances the regulation of many signalling events. Cytoskeletal signalling complexes facilitate this process by optimizing the relay of messages from membrane receptors to specific sites on the actin cytoskeleton...
Articles
Hepatocyte couplets
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2000) 28 (2): 136–140.
Published: 01 February 2000
... -aminophenoxy)ethane- N,N ,N’,N’-tetra-acetic acid acetoxymethyl ester PKA, protein kinase A PKC, protein kinase C bile formation cholestasis cytoskeleton polarized cells tight junctions Biochemical Society Transactions (2000) Volume 28, part 2 Hepatocyte couplets R. Coleman*' and M. G. Romat...
