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Keywords: cytotoxic T-lymphocyte
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Articles
mTORC1 regulates CD8 + T-cell glucose metabolism and function independently of PI3K and PKB
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (2): 681–686.
Published: 21 March 2013
.... In many cell systems, mTORC1 couples PI3K (phosphoinositide 3-kinase) and PKB (protein kinase B), also known as Akt, with the control of glucose uptake and glycolysis. However, this is not the case in activated CD8 + CTLs (cytotoxic T-lymphocytes) where PI3K/PKB signalling is dispensable for the elevated...
