... species due to their oxidation-reduction activities, which consequently make them prone to oxidative damage, misfolding, and aggregation. As a result, quality control mechanisms through turnover and degradation are required for maintaining mitochondrial activity. Degradation of OXPHOS subunits can...

...Yan Hu; Fulvio Reggiori Macroautophagy, hereafter autophagy, is a degradative process conserved among eukaryotes, which is essential to maintain cellular homeostasis. Defects in autophagy lead to numerous human diseases, including various types of cancer and neurodegenerative disorders...

...Hagai Abeliovich; Jörn Dengjel The degradation of malfunctioning or superfluous mitochondria in the lysosome/vacuole is an important housekeeping function in respiring eukaryotic cells. This clearance is thought to occur by a specific form of autophagic degradation called mitophagy, and plays...

... of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, U.K. 5 9 2013 antioxidant response cancer cell signalling degradation drug design ubiquitylation The KLHL (Kelch-like) family of proteins represent the largest group of BTB-containing substrate...

...Xiaoting Wu; Hyeran Won; David C. Rubinsztein Autophagy is a highly conserved cytoplasmic degradation pathway that has an impact on many physiological and disease states, including immunity, tumorigenesis and neurodegeneration. Recent studies suggest that autophagy may also have important functions...

... expression. Post-transcriptional regulation alone has many points of control, including changes in the stability, translatability or susceptibility to degradation of RNA species, where both cis - and trans -acting elements will play a role in the outcome. The present review concentrates on just one aspect...

...Francesca Mateo; Miriam Vidal-Laliena; Maria Jesus Pujol; Oriol Bachs Cyclin A must be degraded at prometaphase in order to allow mitosis progression. Nevertheless, the signals that trigger cyclin A degradation at mitosis have been largely elusive. In the present paper, we review the status...

.... Salvat C. Piechaczyk M. Ubiquitinylation is not an absolute requirement for degradation of c-Jun protein by the 26 S proteasome J. Biol. Chem. 1995 270 11623 11627 44 Basbous J. Chalbos D. Hipskind R. Jariel-Encontre I. Piechaczyk M. Ubiquitin-independent...

... complex/cyclosome (APC/C) cytokinesis degradation proteolysis substrate targeting At the core of the eukaryotic cell cycle lies the switch between interphase and mitosis that arises from the mutual regulation between CDKs (cyclin-dependent kinases) and the APC/C (anaphase-promoting complex...

..., internalization, dephosphorylation and degradation are key elements of the signalling network. The understanding of such mechanisms is essential for the design of therapeutic strategies targeting PKC isoenzymes. 1 To whom correspondence should be addressed (email [email protected] ). 2 7 2007...

.... In degeneration, synthesis of matrix molecules changes, leading to an increase in the synthesis of collagens type I and III and a decreased production of aggrecan. Linked to this is an increased expression of matrix-degrading molecules including MMPs (matrix metalloproteinases) and the aggrecanases, ADAMTS...

... for therapeutic treatment of diabetes [ 73 ]. brain degradation matrix-assisted laser-desorption ionization (MALDI) neuropeptide imaging peptidomics proteomics Proteomics is the large-scale study of proteins. It was originally defined as the protein complement expressed by a genome [ 1...

...P. van Kerkhof; G. J. Strous The growth hormone (GH) receptor (GHR) is a mammalian plasma membrane protein whose internalization is mediated by the ubiquitin-proteasome pathway. GH internalization and degradation are inhibited when cells are treated with proteasome inhibitors. Here we show...