... & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with UC. antigen presentation cancer dendritic cells stroma T-cells vaccines Antigen processing and presentation by antigen-presenting cells (APCs) comprises the sentinel phase...

...Mickaël M. Ménager Dendritic cells (DCs) have essential roles in early detection of pathogens and activation of both innate and adaptive immune responses. Whereas human DCs are resistant to productive HIV-1 replication, they have a unique ability to take up virus and transmit it efficiently to T...

...) responses. Human dendritic cells pulsed with peptide-loaded microbial HSP70 complexes generate potent antigen-specific CTL responses. Using fluorescence anisotropy, we have calculated the peptide-binding affinity of mycobacterial HSP70 ( K D =14 μM) and show that 120 pM HSP70-bound peptide is sufficient...