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Keywords: detergent
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Articles
Biochem Soc Trans (2014) 42 (5): 1460–1464.
Published: 18 September 2014
... pharmacological drugs. The natural sphingolipid sphingosine exhibits lysosomotropic detergent ability and is an endogenous candidate for controlling lysosomal membrane permeabilization. The lysosomotropic properties of certain detergents might be of use in lysosome-targeting anticancer drugs and drug delivery...
Articles
Biochem Soc Trans (2013) 41 (1): 185–190.
Published: 29 January 2013
... drug discovery [ 3 ]. 1 To whom correspondence should be addressed ( fiona.marshall@heptares.com ). 5 10 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 detergent G-protein-coupled receptor membrane protein thermostability Although...
Articles
Biochem Soc Trans (2012) 40 (6): 1291–1294.
Published: 21 November 2012
... and functional mechanisms of this focal protein. Understanding the structure and function of membrane proteins is hampered by inherent difficulties associated with their purification since the choice of the detergents play a critical role in the protein structure and stability. In the present mini-review, we...
Articles
Biochem Soc Trans (2011) 39 (3): 703–706.
Published: 20 May 2011
... be addressed (email Jme1@soton.ac.uk ). 16 3 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 ATPase detergent drug interaction lipid–protein interaction membrane sarcoplasmic/endoplasmic reticulum Ca 2+ -ATPase (SERCA) When we began planning the Biochemical...
Articles
Biochem Soc Trans (2011) 39 (3): 775–779.
Published: 20 May 2011
...Richard J. Cogdell; Alastair T. Gardiner; Aleksander W. Roszak; Sigitas Stončius; Pavel Kočovský; Neil W. Isaacs Electron-density maps for the crystal structures of membrane proteins often show features suggesting binding of lipids and/or detergent molecules on the hydrophobic surface, but usually...
Articles
Biochem Soc Trans (2005) 33 (5): 924–930.
Published: 26 October 2005
... the binding of cofactors and the provision of structural support. The challenges of modelling surface-associated electron density features such as lipids, detergents, small amphiphiles and ions are discussed. The trimeric cyanobacterial PS-I is a spectacular construction containing 12 polypeptides and 127...
Articles
Biochem Soc Trans (2005) 33 (5): 910–912.
Published: 26 October 2005
...P.J. Bond; J. Cuthbertson; M.S.P. Sansom Interactions between membrane proteins and detergents are important in biophysical and structural studies and are also biologically relevant in the context of folding and transport. Despite a paucity of high-resolution data on protein–detergent interactions...