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Keywords: development
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Articles
Biochem Soc Trans (2024) 52 (6): 2579–2592.
Published: 10 December 2024
... License 4.0 (CC BY) . Open access for this article was enabled by the participation of University of Nottingham in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with JISC. development mechanobiology morphogenesis...
Includes: Supplementary data
Articles
Biochem Soc Trans (2023) 51 (3): 1097–1109.
Published: 14 June 2023
... cell states. In particular, we highlight their functions in the development of mammalian limbs, the inner ear, and craniofacial structure while discussing the genetic and biochemical evidence that showcases their conserved roles in tissue regeneration, disease, and cancer pathogenesis...
Articles
Biochem Soc Trans (2023) 51 (3): 983–993.
Published: 24 May 2023
...Fabian Gude; Jurij Froese; Georg Steffes; Kay Grobe Patterns of gene expression, cell growth and cell-type specification during development are often regulated by morphogens. Morphogens are signalling molecules produced by groups of source cells located tens to hundreds of micrometers distant from...
Articles
Biochem Soc Trans (2023) 51 (3): 1009–1021.
Published: 28 April 2023
... organ development through spatiotemporal averaging . Dev. Cell 38 , 15 – 32 10.1016/j.devcel.2016.06.016 43 Little , S.C. , Tikhonov , M. and Gregor , T. ( 2013 ) Precise developmental gene expression arises from globally stochastic transcriptional activity . Cell 154...
Articles
Biochem Soc Trans (2022) 50 (6): 1693–1702.
Published: 16 November 2022
..., indicating that O -GlcNAc levels are precisely tuned at early developmental stages. Taken together, these results underscore the fundamental and conserved role of O -GlcNAc in the early development of the brain and nervous system. As described above, animal models have paved the way to a better...
Articles
Biochem Soc Trans (2020) 48 (2): 463–478.
Published: 20 April 2020
... zygotes inhibited ZGA and impaired early embryo development. PIAS4 effect is partially caused by the SUMOylation of Developmental Pluripotency Associated 2 (DPPA2), which converts this transcriptional activator to a potent inhibitor of zygotic transcriptional program [ 51 ]. In agreement, another study...
Articles
Biochem Soc Trans (2020) 48 (1): 301–315.
Published: 03 February 2020
... signalling reviews, the reader is referred to Ref. [ 1 , 2 , 4 , 113 ]. Given the emerging link between cancer stemness and disease progression, a better mechanistic understanding of how the PI3K pathway impinges on critical developmental processes — either in forward (normal development) or reverse...
Articles
Biochem Soc Trans (2016) 44 (3): 696–701.
Published: 09 June 2016
..., the structures formed tend to be limited to those that resemble existing tissues, the construction involving changes of gene expression in sequences similar to those seen in normal development in a process that has been termed genetically encoded self-assembly [ 40 ]. A hybrid approach would be to add...
Articles
Articles
Biochem Soc Trans (2014) 42 (4): 1229–1237.
Published: 11 August 2014
..., but not males, are sterile [ 64 , 65 ]. In mammals, hormonal signals trigger the development and maturation of oocytes within follicles that progress through a series of developmental stages and contain somatic cells that respond to and support the growing oocyte. Epab −/− mice have normal oestrus and normal...
Articles
Biochem Soc Trans (2014) 42 (4): 1168–1173.
Published: 11 August 2014
... in the 5′UTR [ 25 ]. The importance of NMD for normal development has been established in earlier genetic studies that uncovered major defects in embryos lacking key NMD factors [ 26 ]. Further underscoring its developmental significance, NMD is known to co-operate with AS to control expression...
Articles
Biochem Soc Trans (2014) 42 (3): 689–695.
Published: 22 May 2014
... is essential for development, with most binding sites for interacting proteins identified to date residing within the S- and NA/NS-domains. development differentiation embryonic stem cell glycosaminoglycan heparan sulfate signalling A key component for the ability of a cell to respond...
Articles
Biochem Soc Trans (2013) 41 (6): 1489–1494.
Published: 20 November 2013
... in embryogenesis and development. Many autophagy gene-knockout mice have embryonic lethality at different stages of development. Furthermore, interactions of autophagy with crucial developmental pathways such as Wnt, Shh (Sonic Hedgehog), TGFβ (transforming growth factor β) and FGF (fibroblast growth factor) have...
Articles
Biochem Soc Trans (2013) 41 (6): 1720–1725.
Published: 20 November 2013
... of the sites of replication initiation, or origins, across the genome. Interestingly, origin usage changes during development and in different pathologies, suggesting an integral interplay between the establishment of replication initiation along the chromosomes and cellular function. The present review...
Articles
Biochem Soc Trans (2012) 40 (4): 784–788.
Published: 20 July 2012
... to increased inclusion of CD44 alternative exons associated with metastasis. Recent research has identified new physiological target RNAs for Tra2β in development, and revealed it as an important developmental splicing regulator. Gradients in Tra2β protein concentrations may drive exon inclusion...
Articles
Biochem Soc Trans (2010) 38 (4): 1137–1143.
Published: 26 July 2010
...Christopher I. Jones; Sarah F. Newbury Control of mRNA translation and degradation has been shown to be key in the development of complex organisms. The core mRNA degradation machinery is highly conserved in eukaryotes and relies on processive degradation enzymes gaining access to the mRNA. Control...
Articles
Biochem Soc Trans (2010) 38 (2): 507–510.
Published: 22 March 2010
... that recapitulate developmental phenotypes of FXS will be indispensable for distinguishing between these alternatives. Furthermore, it will be necessary to understand the cellular and molecular mechanisms whereby FMRP influences development, in particular, whether FMRP plays modulatory or instructive roles...
Articles
Biochem Soc Trans (2008) 36 (6): 1267–1271.
Published: 19 November 2008
... of nutrition in cognitive development Handbook of Developmental Cognitive Neuroscience 2008 2nd edn MA, U.S.A. MIT Press, Cambridge 623 642 8 Siddappa A.J. Rao R. Long J.D. Widness J.A. Georgieff M.K. The assessment of newborn iron stores at birth: a review of the literature...
Articles
Biochem Soc Trans (2008) 36 (5): 868–873.
Published: 19 September 2008
... paper describing the role of Smt3 during metamorphasis was published, representing a new function for SUMOylation during development [ 61 ]. A growing body of evidence relates SUMOylation to crucial cellular and developmental processes. In development, where transcription, translation...
Articles
Biochem Soc Trans (2008) 36 (4): 629–631.
Published: 22 July 2008
...Jörg Hartkamp; Stefan G.E. Roberts The Wilms' tumour-suppressor gene ( WT1 ), encodes a zinc-finger transcription factor that is critical for the development of several organs, including the kidneys, gonads and spleen. Despite its identification as a tumour suppressor that plays a crucial role...
Articles
Biochem Soc Trans (2004) 32 (5): 792–796.
Published: 26 October 2004
...H. Wang; Y. Lee; C.C. Malbon Wnt signalling in development operates via members of the Frizzleds, G-protein-coupled receptors that bind specific Wnt ligands and mediate signalling via distinct pathways. The Wnt/Ca 2+ /cGMP pathway mediated by Frizzled-2 was discovered recently. Activation...
Articles
Biochem Soc Trans (2001) 29 (2): 76–80.
Published: 01 May 2001
...F. Villarroya; S. Brun; M. Giralt; Y. Cámara; G. Solanes; R. Iglesias Uncoupling proteins (UCPs) are considered to be major determinants of energy expenditure in mammals. During development in rodents, the expression of the UCP genes occurs sequentially. UCP2 mRNA is expressed long before birth...