... the involvement of phosphoinositides and their derivatives such as diacylglycerol (DAG) in fusion [ 6 , 18 – 20 ]. Membrane lipids alter the energetics of fusion [ 16 ]. Lipids of negative curvature such as DAG, cholesterol and phosphatidylethanolamine tend to disrupt bilayers and induce fusion [ 15 , 21 – 23...

...H. Wang; M.G. Kazanietz We have established a novel role for the second messenger DAG (diacylglycerol), a product of PtdIns(4,5) P 2 hydrolysis by PLC (phospholipase C). In addition to its well-known function as a protein kinase C activator, DAG produced by stimulation of the epidermal growth...

... cycle 25) domain. RasGRP1 also possesses a DAG (diacylglycerol)-binding C1 domain and a pair of EF hands that bind calcium. RasGRP1 is selectively expressed in lymphocytes as well as in some cells of the brain, kidney and skin. Functional analysis supports the hypothesis that RasGRP1 serves to couple...

... body of evidence suggests that certain lipids, such as phosphoinositides and diacylglycerol, regulate Golgi-mediated transport events. However, their exact role in this process, and the underlying mechanisms that maintain their critical levels in specific membrane domains of the Golgi apparatus, remain...

..., and to produce the lipid second messenger diacylglycerol in response to BCR cross-linking. Therefore the functional integrity of the BTK/PLC-γ2/diacylglycerol signalling axis is crucial for BCR-directed activation of both transcription factors NFAT and NF-κB. 1 To whom correspondence should be addressed (e...

... 2003 Biochemical Society 2003 acetyl-CoA carboxylase Akt atherosclerosis diacylglycerol fatty acid oxidation fuel sensing oxidative stress protein kinase C tumour necrosis factor α Abbreviations used: ACC, acetyl-CoA carboxylase; AICAR, 5-amino-4-imidazolecarboxamide riboside...

... Society 2001 ceramide diacylglycerol endothelial differentiation gene receptors lysophosphatidate phosphatidate sphingosine 1-phosphate ARF, ADP ribosylation factor CIP, ceramide 1-phosphate DAG, diacylglycerol EDG, endothelial differentiation gene ERK, extracellular-signal-regulated...