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Keywords: drug design
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Biochem Soc Trans (2020) 48 (5): 2067–2078.
Published: 01 September 2020
... molecular targets, Pf DHFR, Pf DHODH and Pf A-M1, and their associated inhibitors which demonstrate how mechanism can inform drug design and be effectively utilised to generate compounds with potent inhibitory activity. The elucidation of the Pf DHFR WT and QM crystal structures allowed for a renaissance...
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Biochem Soc Trans (2016) 44 (1): 79–87.
Published: 09 February 2016
... is used by one enzyme or another. In the Mercator representation, 4 H 3 is about in the same location as Greenland. The ‘take home’ message of this section is that although Greenland is beautiful, there are other places worth exploring! biofuels conformational analysis drug design glycobiology...
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Biochem Soc Trans (2015) 43 (4): 531–536.
Published: 03 August 2015
... Limited 2015 apoptosis drug design glioblastoma translocator protein Identification of GM imaging biomarkers may assist in clinical diagnosis and outcome prediction. Oncology studies often use 2-deoxy-2-[18F]fluoroglucose as a diagnostic marker, but the high use of glucose by normal...
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Biochem Soc Trans (2014) 42 (1): 103–107.
Published: 23 January 2014
... cancer cell signalling degradation drug design ubiquitylation Specific patterns of mono- or poly-ubiquitylation are used by the cell to control protein function or stability. These common post-translational modifications involve a three-enzyme cascade that directs the covalent linkage...
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Biochem Soc Trans (2011) 39 (5): 1311–1312.
Published: 21 September 2011
... author (email [email protected] or [email protected] ). 18 7 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 Chinese biochemistry Chinese–U.K. research collaboration drug design insulin structural biology U.K. biochemistry A joint Sino...
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Biochem Soc Trans (2007) 35 (4): 707–708.
Published: 20 July 2007
... articles. 1 To whom correspondence should be addressed (email [email protected] ). 11 5 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 drug design G-protein-coupled receptor (GPCR) ligand binding molecular modelling receptor activation...
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Biochem Soc Trans (2005) 33 (4): 767–771.
Published: 01 August 2005
... and rational drug design. The applications of NMR spectroscopy and isothermal titration calorimetry to study enzyme–ligand interactions will be discussed. Recent work on ketopantoate reductase, which catalyses an important step on the biosynthetic pathway to vitamin B5, is used to illustrate the potential...
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Biochem Soc Trans (2004) 32 (1): 28–32.
Published: 01 February 2004
... Cascades, a Biochemical Society Focused Meeting held at GlaxoSmithKline, Stevenage, 9 September 2003 12 August 2003 © 2004 Biochemical Society 2004 complement system compstatin drug design molecular dynamics NMR peptide Abbreviations used: Ac, acetyl; MD, molecular...
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Biochem Soc Trans (2003) 31 (3): 523–527.
Published: 01 June 2003
... 2 Present address: Biochemishes Institut, Universität Zürich, Winterthurerstrasse 190, CH-8057, Zürich, Switzerland. 16 December 2002 © 2003 Biochemical Society 2003 distortion drug design glycoside hydrolase inhibition reaction mechanism transition state Enzyme...
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Biochem Soc Trans (2002) 30 (6): 1026–1036.
Published: 01 November 2002
... be addressed (e-mail [email protected] or [email protected] ) 21 6 2002 © 2002 Biochemical Society 2002 complement system drug design NMR Ac, acetyl group C5aR, C5a receptor dCha, D-cyclohexylalanine dX, D-isomer of amino acid X Nme, N-methylamide Biochemical...
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Biochem Soc Trans (2001) 29 (6): 692–696.
Published: 01 November 2001
[email protected] 31 5 2001 © 2001 Biochemical Society 2001 anticancer drug design G-quadruplex Biochemical Society Transactions (200 I) Volume 29, part 6 ~ ~ Secondary DNA structures as molecular targets for cancer therapeutics L. H. Hurley' College of Pharmacy, The University of Arizona...
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Biochem Soc Trans (2000) 28 (2): 186–190.
Published: 01 February 2000
...,6BP, fructose 1,6-bisphosphate allosteric regulation drug design effector site fructose 2,6-bisphosphate trypanosomatid Biochemical Society Transactions (2000) Volume 28, part 2 acyl-CoA. The enzyme properties and locations are consistent with this. Above all, the carnitine derivatives...