...: Elisa Aquilanti ( [email protected] ) 8 2 2024 5 8 2024 6 8 2024 © 2024 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2024 anti-cancer therapies drug discovery telomerase telomeres Damon Runyon Physician...

... on behalf of the Biochemical Society 2022 airway modeling drug discovery lung disease modeling lung organoid applications lung stem cells lung-on-a-chip The lung is one of the most complex organs in the body and is composed of many different cell types, each having a widely diversified...

...-Yin Zhang ( [email protected] ) 3 6 2021 28 7 2021 30 7 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 chemical biology drug discovery protein tyrosine phosphatase Post-translational phosphorylation...

... and scope of implementing OoCs across the drug discovery process are also discussed. Correspondence: Augustin Amour ( [email protected] ) 21 6 2021 20 7 2021 26 7 2021 © 2021 The Author(s) 2021 This is an open access article published by Portland Press Limited...

...Tom Ceska; Chun-Wa Chung; Rob Cooke; Chris Phillips; Pamela A. Williams The impact of structural biology on drug discovery is well documented, and the workhorse technique for the past 30 years or so has been X-ray crystallography. With the advent of several technological improvements, including...

... considerable resources for follow-up activities in a drug discovery project. To simplify this validation process, a graphical scheme — the validation cross — can be used. This simple graphic is a powerful tool for identifying blind spots of a binding hypothesis, for selecting the most informative combination...

...–function relationships. Today, this information is vital to drug discovery and medicine. In the last two decades, many have been the technical advances and breakthroughs in the field of MP structural biology that have contributed to an exponential growth in the number of unique MP structures in the Protein...

...Richard Carr, III; Jeffrey L. Benovic For over a decade, pepducins have been utilized to develop unique pharmacological profiles that have been particularly challenging for traditional drug discovery methods. It is becoming increasingly clear that these cell-penetrating lipopeptides can access...

...; published by Portland Press Limited 2015 Kelch-like ECH-associated protein 1 (Keap1) drug discovery nuclear factor erytheroid-2-related factor 2 (Nrf2) protein–protein interactions CDDO-Me bardoxolone methyl FP fluorescence polarization HO1 haeme oxygenase-1 Keap1...

... of activation can be exploited in drug discovery. In the case of Aurora-A, the flexibility of the activation loop shown in the unphosphorylated kinase has been exploited in the design of kinase inhibitors that bind an inactive conformation in which the activation loop is flipped from the position found...

.... In the present paper, we review recent genomic and biochemical evidence implicating Mycobacterium tuberculosis CYP (cytochrome P450) enzymes as exciting potential targets for new classes of anti-tuberculars. We also discuss HTS (high-throughput screening) and fragment-based drug-discovery campaigns...

.... The emerging role of lysophosphatidic acid in cancer Nat. Rev. Cancer 2003 3 582 591 2 Tigyi G. Aiming drug discovery at lysophosphatidic acid targets Br. J. Pharmacol. 2010 161 241 270 3 Stracke M.L. Krutzsch H.C. Unsworth E.J. Arestad A. Cioce V...

... relationship) data, which can be used to support chemical biology, lead discovery and target selection in drug discovery. The database contains the abstracted structures, properties and biological activities for over 700000 distinct compounds and in excess of more than 3 million bioactivity records abstracted...

...Claire N. Medine; Sebastian Greenhough; David C. Hay Accurate prediction of human drug toxicity is a vital part of the drug discovery process. However, the safety evaluation process is hindered by the availability and quality of primary human liver models with which to study drug toxicity...

... The Authors Journal compilation © 2010 Biochemical Society 2010 drug discovery embryonic stem cell high-content screening high-throughput screening induced pluripotent stem cell Arguably the biggest advantage of using small compounds as opposed to producing genetic mutations to analyse cellular...

...Daniel J. Maltman; Stefan A. Przyborski Drug discovery programmes require accurate in vitro systems for drug screening and testing. Traditional cell culture makes use of 2D (two-dimensional) surfaces for ex vivo cell growth. In such environments, cells are forced to adopt unnatural characteristics...

...D.A. Middleton Structure-based design has gained credibility as a valuable component of the modern drug discovery process. The technique of SSNMR (solid-state NMR) promises to be a useful counterpart to the conventional experimental techniques of X-ray crystallography and solution-state NMR...

...G.P. Belfield; S.J. Delaney The discipline of molecular biology has become increasingly important in recent times for the process of drug discovery. We describe the impact of molecular biology across the whole process of drug discovery and development, including (i) the identification...

...J.G. McCormack Scientists and science in the pharmaceutical industry rely heavily on the more academically orientated basic research carried out at Universities, for first of all training, but also as a source of new ideas and approaches to drug discovery. Progress in the discovery and development...

... disease amyloid drug discovery immunization protease secretase AD (Alzheimer's disease) is a progressive, degenerative brain disorder resulting in cognitive and behavioural decline and is the leading cause of dementia in the Western world. Much effort is currently directed at developing...

...’. The case of GK research illustrates how basic science may culminate in therapeutic advances of human medicine. 2 9 2004 © 2005 The Biochemical Society 2005 drug discovery genetics glucose glucokinase glucose homeostasis therapeutics References 1 Bell G.I. Cuesta...

... is determined by the ratio of its association to dissociation rates, a molecular mechanism for the effects of allosteric ligands that behave according to the ATCM is the modulation of orthosteric ligand association and/or dissociation [ 5 , 10 ]. In terms of drug discovery, structure–activity studies...

...B.A. Wallace; Robert W. Janes CD spectroscopy is an established and valuable technique for examining protein structure, dynamics and folding. Because of its ability to sensitively detect conformational changes, it has important potential for drug discovery, enabling screening for ligand and drug...