... factors cancer drug discovery and design molecular basis of health and disease References 1 Buttgereit , F. and Brand , M.D . (1995) A hierarchy of ATP-consuming processes in mammalian cells . Biochem. J. 312 (Pt 1) , 163 – 167 https://doi.org/10.1042...

... and the Biochemical Society under a transformative agreement with JISC. βTrCP cancer drug discovery and design NRF2 beta -Transducin repeat-containing protein (βTrCP) is one of 69 human F-box proteins [ 1–3 ] that play roles in regulating the activity of cell cycle proteins and transcription factors...

...(s). Published by Portland Press Limited on behalf of the Biochemical Society 2023 allosteric regulation drug discovery and design kinases Eukaryotic protein kinases regulate a wide array of cellular processes through the catalytic transfer of a phosphate group from adenosine...

... phenotypes. biological networks cellular localization drug discovery and design G-protein-coupled receptors signalling systems biology 5 12 2022 11 1 2023 12 1 2023 © 2023 The Author(s) 2023 This is an open access article published by Portland Press Limited...

... Tuberculosis and now found to be active against Leishmania donovani [ 38 ]. chemogenomics drug discovery and design trypanosomes Trypanosomatids are eukaryotic parasites that cause neglected tropical diseases (NTD) [ 1 ]. Human African trypanosomiasis, Chagas disease and different clinical...

... 2022 The Author(s) 2022 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . breast cancers cancer drug discovery and design JNK molecular scaffolds...

...-ND) . antibiotics biosynthesis drug discovery and design metabolic engineering Antimicrobial-resistant (AMR) infections pose a serious threat to society [ 1 ], driving the need to discover and develop new antimicrobial molecules. Promising sources of such antimicrobials are naturally...

... © 2022 The Author(s) 2022 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . drug discovery and design organ on chip translational science The high...

... Society 2022 computational biochemistry computational biology drug discovery and design molecular docking platforms protein structure Drug repurposing possesses great advantages in terms of establishing new therapeutic options for specific disorders by exploiting drugs used for other...

... knowledge needed for pre-clinical screening of compounds in non-human species. Multiple structures within a chemical series are also important for establishing SAR. biologics cryo-EM drug discovery and design small molecule vaccines Structure-based drug design (SBDD) has been an essential...

... conservation between host and pathogen ortholog enzymes. 16 12 2019 10 3 2020 16 3 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 cancer drug discovery and design malaria NAD biology NAD dehydrogenases tuberculosis...

[email protected] ) 30 10 2019 4 12 2019 9 12 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 drug discovery and design palmitoylation protein S-acylation thioesterase zDHHC protein acyltransferase Protein S-acylation...

... picture of membrane proteins in general and GPCRs in particular [ 36 – 38 ]. Receptor activation/de-activation represents an important aspect where atomistic simulations have helped uncover molecular details in close collaboration with experimental observations [ 39 – 41 ]. drug discovery and design...

...) 2018 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . drug discovery and design fibroblast growth factor receptors receptor tyrosine kinases structural biology...

... biochemistry drug discovery and design structural biology Computational methods of drug discovery have a basis in the very earliest structural studies of protein molecules. The first structure of a protein, that of sperm whale myoglobin initially at 6 Å resolution [ 1 ] then refined to 2 Å resolution...

... of intermediate sulfation (NS/NA domain) that interject unmodified regions (NA domain) [ 41 , 42 ]. Figure 1. HS structure and modification. HPSE, heparanase; SULF, sulfatase. drug discovery and design heparan sulfate host–pathogen interactions Leishmania parasitology proteoglycan...

... BY) . calnexin drug discovery and design glucosidase glycobiology iminosugar Enveloped viruses have a membrane surrounding their capsid, which is composed of lipids derived from host membranes and viral glycoproteins. These viral glycoproteins are typically dependent upon the host endoplasmic...