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Keywords: drug discovery and design
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Biochem Soc Trans (2023) 51 (3): 925–936.
Published: 09 June 2023
.... In this review the structure, function and rationale for targeting βTrCP are discussed along with the strategies that have been used to develop small molecule and peptide inhibitors. βTrCP cancer drug discovery and design NRF2 Human βTrCP has two isoforms, βTrCP1 is a 569 amino acid protein...
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Biochem Soc Trans (2023) 51 (1): 373–385.
Published: 16 February 2023
... to this work. 1 11 2022 31 1 2023 1 2 2023 © 2023 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2023 allosteric regulation drug discovery and design kinases Eukaryotic protein kinases regulate a wide array of cellular processes...
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Biochem Soc Trans (2023) 51 (1): 13–20.
Published: 23 January 2023
... localization drug discovery and design G-protein-coupled receptors signalling systems biology 5 12 2022 11 1 2023 12 1 2023 © 2023 The Author(s) 2023 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under...
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Biochem Soc Trans (2023) 51 (1): 195–206.
Published: 06 January 2023
... drug discovery and design trypanosomes Data on activity of diverse chemical compounds against whole organisms, cells or defined targets is accumulating steadily. As a consequence, the last decade has seen many databases with a comprehensive understanding of drug discovery pipelines...
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Biochem Soc Trans (2022) 50 (5): 1315–1328.
Published: 05 October 2022
...-ND) . antibiotics biosynthesis drug discovery and design metabolic engineering Antimicrobial-resistant (AMR) infections pose a serious threat to society [ 1 ], driving the need to discover and develop new antimicrobial molecules. Promising sources of such antimicrobials are naturally...
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Biochem Soc Trans (2022) 50 (2): 665–673.
Published: 19 April 2022
... © 2022 The Author(s) 2022 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . drug discovery and design organ on chip translational science The high...
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Biochem Soc Trans (2022) 50 (2): 747–758.
Published: 14 March 2022
... computational biochemistry computational biology drug discovery and design molecular docking platforms protein structure Phenotypic drug discovery has in broad terms been highly successful. The process closely simulates the normal physiological situation. It allows conception and testing...
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Biochem Soc Trans (2021) 49 (6): 2627–2638.
Published: 23 November 2021
... the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . biologics cryo-EM drug discovery and design small molecule vaccines Structure-based drug design (SBDD) has been an essential tool in pharmaceutical development for decades. Structures of macromolecular drug targets, especially when...
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Biochem Soc Trans (2020) 48 (1): 281–290.
Published: 24 December 2019
[email protected] ) 30 10 2019 4 12 2019 9 12 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 drug discovery and design palmitoylation protein S-acylation thioesterase zDHHC protein acyltransferase Importance...
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Biochem Soc Trans (2019) 47 (3): 909–918.
Published: 13 May 2019
.... drug discovery and design molecular dynamics neuropathology In this context, MD simulations-based techniques have been recently been of help in identifying ligands targeting RNAs in expanded CAG repeats diseases, the most widespread neurodegenerative disorders after Parkinson's...
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Biochem Soc Trans (2018) 46 (6): 1753–1770.
Published: 13 December 2018
... resonance energy transfer (FRET)-based studies of FGF1 and FGF2 binding to FGFRs 1–3 show differences in ligand-induced helix separation, and at least in the case of FGFR3, this further correlates with the level of receptor (auto)phosphorylation [ 27 , 36 ]. drug discovery and design fibroblast...
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Biochem Soc Trans (2018) 46 (5): 1367–1379.
Published: 21 September 2018
... on behalf of the Biochemical Society 2018 computational biochemistry drug discovery and design structural biology In the majority of cases, the choice of binding site may be an obvious one; for example, the orthosteric agonist site of a receptor or the catalytic site of an enzyme. However...
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Biochem Soc Trans (2018) 46 (4): 789–796.
Published: 22 June 2018
... susceptibility for parasite invasion. Knowledge of these underpinning structure:function relationships will assist in the development of novel HS-targeted therapeutics with reduced toxicity and side effects, while expanding our knowledge of the role of host HS in Leishmania infection. drug discovery...
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Biochem Soc Trans (2017) 45 (2): 571–582.
Published: 13 April 2017
... BY) . calnexin drug discovery and design glucosidase glycobiology iminosugar Enveloped viruses have a membrane surrounding their capsid, which is composed of lipids derived from host membranes and viral glycoproteins. These viral glycoproteins are typically dependent upon the host endoplasmic...