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1-13 of 13
Keywords: drug resistance
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Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (6): 1911–1920.
Published: 10 November 2022
... insights into tumor heterogeneity, cancer genome remodeling, and drug resistance. Correspondence: Paul Mischel ( [email protected] ) 12 7 2022 17 10 2022 17 10 2022 © 2022 The Author(s) 2022 This is an open access article published by Portland Press Limited on behalf...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (3): 1259–1268.
Published: 17 June 2022
... of virulence and drug resistance traits. We focus on the contribution of comparative genomics, population genomics and directed evolution studies. In addition, we discuss how different types of genomic mutations (small or structural variants) contribute to intraspecific differences in virulence or drug...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (6): 2791–2810.
Published: 01 December 2020
... as genomic junk. LncRNAs are involved in various physiological as well as pathological conditions, and play a key role in drug resistance, gene expression, and epigenetic regulation. This review mainly focuses on exploring the multifunctional roles of candidate lncRNAs, and their strong association with TNBC...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (2): 657–665.
Published: 20 April 2020
... resistance mechanisms. Correspondence: Sima Lev ( [email protected] ) 4 2 2020 26 3 2020 30 3 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 drug resistance EGFR target therapy Triple-negative...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (5): 1018–1022.
Published: 09 October 2015
... given in combination to circumvent chemoresistance, but several studies have demonstrated it to be ineffective in the absence of radiotherapy. The identification of children with drug-resistant disease at the outset could allow stratification of those that are potentially curable by chemotherapy alone...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 804–808.
Published: 11 August 2014
... of the cellular mechanisms of drug resistance is required, along with rationally designed novel therapies targeting perhaps not only the tumour, but also the bone marrow niche that supports it. Signalling and Acquired Resistance to Targeted Cancer Therapeutics: A Biochemical Society Focused Meeting held...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 733–741.
Published: 11 August 2014
... 1/2) activation [ 45 ]. Clinical trials testing the combination of PI3K and HER2 inhibitors are ongoing ( Table 2 ). breast cancer drug resistance phosphoinositide 3-kinase (PI3K) signalling targeted therapy Allosteric Akt inhibition reactivates several RTKs in a Foxo...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 816–821.
Published: 11 August 2014
... Correspondence may be addressed to either of these authors (email [email protected] or [email protected] ). 21 1 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 cancer cross-talk drug resistance Hippo/mammalian sterile 20 (MST) pathway phosphoinositide 3...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 831–836.
Published: 11 August 2014
... in models of resistant cancers, as well as in patients. In the present article, we describe some of the roles in which HER3 can mediate acquired resistance and discuss the current efforts to target HER3 itself in cancer. cancer drug resistance epidermal growth factor receptor (EGFR) human epidermal...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 727–732.
Published: 11 August 2014
... , 31 ] ( Figure 1 D). 1 email [email protected] 14 1 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 BRAF drug resistance melanoma microphthalmia-associated transcription factor (MITF) mitogen-activated protein kinase...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (3): 807–811.
Published: 20 May 2011
...Rupak Doshi; Daniel A.P. Gutmann; Yvonne S.K. Khoo; Lisa A. Fagg; Hendrik W. van Veen Multidrug transporters have a crucial role in causing the drug resistance that can arise in infectious micro-organisms and tumours. These integral membrane proteins mediate the export of a broad range of unrelated...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (6): 1537–1542.
Published: 24 November 2010
... that, upon stress withdrawal, endoplasmic-reticulum-bound transcripts resume translation faster than those at the cytosol, which have been sequestered into stress granules. This may represent a novel mechanism by which drug-resistant cells respond quickly to stress, helping them to survive the cytotoxic...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (5): 1219–1223.
Published: 26 October 2005
... albicans drug resistance ergosterol lipid raft morphogenesis sphingolipid The existence of discrete membrane microdomains, known as lipid rafts within a lipid bilayer, predominantly composed of sphingolipid and sterol, are well documented in several systems [ 1 – 5 ]. Interestingly...