... switch’ in eicosanoid production [ 24 ]. Clearly, a key part of the resolution phase of inflammation is the ‘sensing’ of dying leukocytes followed by their removal. Many mechanisms by which phagocytes are recruited to dying cells have been proposed (reviewed in detail, [ 25 ]). Besides lipid...

... aspects of inflammation including leucocyte chemotaxis, adhesion molecule expression and leucocyte–endothelial adhesive interactions, production of eicosanoids like prostaglandins and leukotrienes from the n-6 fatty acid arachidonic acid and production of pro-inflammatory cytokines. In addition, EPA gives...

... systems, and can facilitate the study of these mediators. 1 To whom correspondence should be addressed (email [email protected] ). 27 5 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 cyclo-oxygenase (COX) cytochrome P450 (CYP450) eicosanoid...

...Benjamin H. Maskrey; Valerie B. O'Donnell Eicosanoids are oxidized arachidonate-derived lipids products generated by lipoxygenase, cyclo-oxygenase and cytochrome P450. Their bioactivity is mediated via receptor-dependent mechanisms and they are involved in a diverse array of processes in both...

.... However, n –3 fatty acids have a number of other effects that might occur downstream of altered eicosanoid production or are independent of this. For example, they result in suppressed production of pro-inflammatory cytokines and can modulate adhesion molecule expression. These effects occur at the level...

... Area Section held at Royal College of Surgeons in Ireland, Dublin, 25–26 June 2003 14 July 2003 © 2003 Biochemical Society 2003 atherosclerosis conjugated linoleic acid cyclo-oxygenase (COX) eicosanoid prostaglandin Abbreviations used: COX, cyclo-oxygenase; LDL, low...