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1-9 of 9
Keywords: embryonic stem cell
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Articles
Using embryonic stem cells to understand how glycosaminoglycans regulate differentiation
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (3): 689–695.
Published: 22 May 2014
... factor) and BMP (bone morphogenetic protein) families. Embryonic stem cells derived from mice with mutations in components of the HS biosynthetic pathway provide an opportunity to dissect the contribution of HS to signalling pathways critical for regulating stem cell maintenance and differentiation...
Articles
The impact of culture on epigenetic properties of pluripotent stem cells and pre-implantation embryos
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (3): 711–719.
Published: 23 May 2013
... of pluripotent cells in vitro . Recent studies have, however, found that the choice of culture condition has a significant impact on epigenetic profiles of cultured pluripotent cells. Mouse and human ESCs (embryonic stem cells) show substantial epigenetic differences that are dependent on the culture condition...
Articles
Controlling embryonic stem cell proliferation and pluripotency: the role of PI3K- and GSK-3-dependent signalling
Available to PurchaseMelanie J. Welham, Emmajayne Kingham, Yolanda Sanchez-Ripoll, Benjamin Kumpfmueller, Michael Storm, Heather Bone
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (2): 674–678.
Published: 22 March 2011
...Melanie J. Welham; Emmajayne Kingham; Yolanda Sanchez-Ripoll; Benjamin Kumpfmueller; Michael Storm; Heather Bone ESCs (embryonic stem cells) are derived from the inner cell mass of pre-implantation embryos and are pluripotent, meaning they can differentiate into all of the cells that make up...
Articles
Glycosaminoglycans as regulators of stem cell differentiation
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (1): 383–387.
Published: 19 January 2011
...Raymond A.A. Smith; Kate Meade; Claire E. Pickford; Rebecca J. Holley; Catherine L.R. Merry ES (embryonic stem) cell differentiation is dependent on the presence of HS (heparan sulfate). We have demonstrated that, during differentiation, the evolution of specific cell lineages is associated...
Articles
High-content screening of small compounds on human embryonic stem cells
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (4): 1046–1050.
Published: 26 July 2010
...Ivana Barbaric; Paul J. Gokhale; Peter W. Andrews Human ES (embryonic stem) cells and iPS (induced pluripotent stem) cells have been heralded as a source of differentiated cells that could be used in the treatment of degenerative diseases, such as Parkinson's disease or diabetes. Despite the great...
Articles
Role of stem-cell-derived hepatic endoderm in human drug discovery
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (4): 1033–1036.
Published: 26 July 2010
... alternative sources of human hepatocytes which circumvent these issues. The research in our group has focused on generating human hepatic endoderm from the scalable pluripotent stem cell populations, human embryonic stem cells and induced pluripotent stem cells. We have developed efficient and scalable models...
Articles
The ground state of pluripotency
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (4): 1027–1032.
Published: 26 July 2010
.... This is the foundation of mammalian development and of ES (embryonic stem) cell biology. What are the design principles of this naïve cell state? How is pluripotency acquired and maintained? Suppressing activation of ERKs (extracellular-signal-regulated kinases) is critical to establishing and sustaining ES cells...
Articles
The homeodomain protein Nanog and pluripotency in mouse embryonic stem cells
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (6): 1518–1521.
Published: 26 October 2005
...A. Yates; I. Chambers Intrinsic regulators of the pluripotency of mouse ES (embryonic stem) cells include the homeodomain proteins Oct4 and the recently identified Nanog. When overexpressed, Nanog displays the unique attribute of robustly sustaining ES cell self-renewal in the absence...
Articles
Embryonic stem (ES) cells and embryonal carcinoma (EC) cells: opposite sides of the same coin
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (6): 1526–1530.
Published: 26 October 2005
... cells may develop in culture in ways that mimic changes occurring in EC cells during tumour progression. © 2005 The Biochemical Society 2005 blastocyst embryonal carcinoma cell embryonic stem cell germ cell tumour pluripotentcy teratocarcinoma EC embryonal carcinoma ES...