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Articles
Biochem Soc Trans (2019) 47 (1): 265-272.
Published: 21 December 2018
... © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 cardiomyocytes endocytosis membrane potential polyamine transporter polyamines spermidine In an impressive study, Eisenberg et al. showed that supplementation with the naturally...
Articles
Biochem Soc Trans (2018) 46 (3): 565-576.
Published: 20 April 2018
...Claudia Hinze; Emmanuel Boucrot Extracellular macromolecules, pathogens and cell surface proteins rely on endocytosis to enter cells. Key steps of endocytic carrier formation are cargo molecule selection, plasma membrane folding and detachment from the cell surface. While dedicated proteins mediate...
Articles
Biochem Soc Trans (2017) 45 (2): 489-497.
Published: 13 April 2017
.... Correspondence: Luise Florin ( lflorin@uni-mainz.de ) 22 12 2016 15 2 2017 16 2 2017 © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2017 cytomegalovirus endocytosis entry papillomavirus tetraspanins trafficking The...
Articles
Biochem Soc Trans (2016) 44 (5): 1347-1354.
Published: 19 October 2016
... will summarise what is known about the molecular mechanisms mediating ECM endocytosis and how this process impacts on diseases, such as fibrosis and cancer. Correspondence: Elena Rainero ( e.rainero@sheffield.ac.uk ) 6 6 2016 28 7 2016 1 8 2016 © 2016 The Author(s); published...
Articles
Biochem Soc Trans (2016) 44 (2): 474-478.
Published: 11 April 2016
... cell surface recycling deubiquitination endocytosis yeast The process of endocytosis involves packaging of cell surface material into vesicles that are internalized and incorporated into the endosomal system, a complex network that intersects various intracellular trafficking pathways. In...
Articles
Biochem Soc Trans (2015) 43 (3): 471-475.
Published: 01 June 2015
... Society 2015 autophagy connexin 43 endocytosis gap junction ubiquitin Gap junctions (GJs) are intercellular channels, formed by six subunits of a transmembrane protein called connexin (Cx) that mediate the direct communication between the cytoplasm of adjacent cells. Gap junction...
Articles
Biochem Soc Trans (2015) 43 (3): 390-395.
Published: 01 June 2015
... © 2015 Biochemical Society 2015 autophagy endocytosis leucine-rich repeat kinase 2 (LRRK2) nicotinic acid adenine dinucleotide phosphate (NAADP) Parkinson's disease Rab protein Parkinson's disease (PD) is a prominent neurodegenerative disorder without a cure. Mutations in leucine-rich...
Articles
Biochem Soc Trans (2014) 42 (1): 195-200.
Published: 23 January 2014
... adhesion. Loss of TJs has been linked to the pathogenesis of many diseases. The present review focuses on the role of vesicle trafficking in regulation of TJs, in particular trafficking of the TJ protein occludin. We examine how endocytosis and endosomal recycling modulate occludin localization under...
Articles
Biochem Soc Trans (2013) 41 (6): 1562-1568.
Published: 20 November 2013
... to death, especially in inherited sphingolipid storage diseases. IMs are formed during endocytosis and their lipid composition is adjusted for degradation. Their cholesterol content, which stabilizes membranes, decreases and the level of negatively charged BMP, which stimulates sphingolipid...
Articles
Biochem Soc Trans (2012) 40 (6): 1404-1408.
Published: 21 November 2012
...Shreya Mitra; Kwai W. Cheng; Gordon B. Mills Derailed endocytosis is a hallmark of cancer. The endocytic pathway, as demonstrated by our laboratory, is a frequent target of genomic aberrations in cancer and plays a critical role in the maintenance of cellular polarity, stem cell function...
Articles
Biochem Soc Trans (2012) 40 (6): 1368-1372.
Published: 21 November 2012
... consider possible hypotheses in order to explain how alterations of Rab7 function lead to CMT2B. 1 To whom correspondence should be addressed (email cecilia.bucci@unisalento.it ). 2 8 2012 © 2012 The Authors Journal 2012 autophagy Charcot–Marie–Tooth disease endocytosis...
Articles
Biochem Soc Trans (2012) 40 (5): 1117-1122.
Published: 19 September 2012
... compilation © 2012 Biochemical Society 2012 cytoskeleton endocytosis exocytosis leucine-rich repeat kinase 2 (LRRK2) PD (Parkinson's disease) is the second most common neurodegenerative disorder after Alzheimer's disease, affecting more than 1 million people in North America and more than 4...
Articles
Biochem Soc Trans (2010) 38 (6): 1432-1435.
Published: 24 November 2010
... additional homologues are TRPML2 and TRPML3 comprising the TRPML subgroup in the TRP superfamily. The three proteins play apparently key roles along the endocytosis process, and thus their cellular localization varies among the different group members. Thus TRPML1 is localized exclusively to late endosomes...
Articles
Biochem Soc Trans (2010) 38 (6): 1413-1416.
Published: 24 November 2010
... Biochemical Society 2010 endocytosis endosome lysosome multivesicular body (MVB) Lysosomes act as the terminal compartment of the endocytic and autophagic pathways ( Figure 1 ). It is now recognized that the delivery of endocytosed and autophagocytosed macromolecules to lysosomes for...
Articles
Biochem Soc Trans (2010) 38 (6): 1417-1419.
Published: 24 November 2010
... ). 23 9 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 endocytosis endosome lysosome pathogen phagocytosis phagolysosome There is a major advantage for a pathogen to gain entry into cells and that is hiding itself from our immune system yet receiving...
Articles
Biochem Soc Trans (2010) 38 (3): 797-806.
Published: 24 May 2010
...Sebastian Y. Bednarek; Steven K. Backues Two separate families of Arabidopsis dynamin-related proteins, DRP1 and DRP2, have been implicated in clathrin-mediated endocytosis and cell plate maturation during cytokinesis. The present review summarizes the current genetic, biochemical and cell...
Articles
Biochem Soc Trans (2010) 38 (1): 181-186.
Published: 19 January 2010
...Arndt Pechstein; Oleg Shupliakov; Volker Haucke During neurotransmitter release, SVs (synaptic vesicles) fuse at the active zone and are recovered predominantly via clathrin-mediated endocytosis at the presynaptic compartment surrounding the site of release, referred to as the periactive zone. Exo...
Articles
Biochem Soc Trans (2010) 38 (1): 187-191.
Published: 19 January 2010
... characterized these proteins using a combination of biochemical, imaging, structural and genetic techniques. These studies provide valuable information on binding partners, structure and dynamics of HIP1/HIP1R/Sla2p. In general, all suggest a role in CME (clathrin-mediated endocytosis) for the three proteins...
Articles
Biochem Soc Trans (2009) 37 (6): 1184-1188.
Published: 19 November 2009
... pathways to cellular events. 1 To whom correspondence should be addressed (email h.mellor@bristol.ac.uk ). 28 7 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 angiogenesis endocytosis intracellular trafficking vascular endothelial growth factor (VEGF...
Articles
Biochem Soc Trans (2009) 37 (6): 1193-1197.
Published: 19 November 2009
... utilized by endothelial cells to sense a key cytokine in vascular tissues. 1 To whom correspondence should be addressed (email s.ponnambalam@leeds.ac.uk ). 6 7 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 angiogenesis endocytosis proteolysis receptor...
Articles
Biochem Soc Trans (2009) 37 (5): 1072-1076.
Published: 21 September 2009
... on the role of different trafficking pathways in epithelial cell migration, including clathrin-mediated endocytosis, caveolar endocytosis, exocytosis of biosynthetic cargo, ‘short-loop’ and ‘long-loop’ endosomal recycling. 1 To whom any correspondence should be addressed (email J.rappaport...
Articles
Biochem Soc Trans (2009) 37 (5): 1019-1021.
Published: 21 September 2009
... lysosomes. 1 To whom correspondence should be addressed (email jpl10@cam.ac.uk ). 22 6 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 endocytosis endosome lysosome multivesicular body vesicle-associated membrane protein 7 (VAMP7) Endocytic...
Articles
Biochem Soc Trans (2009) 37 (5): 1027-1031.
Published: 21 September 2009
... Biochemical Society 2009 Charcot–Marie–Tooth disease endocytosis neurite outgrowth neurodegeneration Rab7 Rab protein The CMT disease (Charcot–Marie–Tooth disease) is one of the most common groups of inherited neuropathies that affect peripheral nerves [ 1 ]. Peripheral nerves connect the...
Articles
Biochem Soc Trans (2009) 37 (1): 178-180.
Published: 20 January 2009
... expressing K3 is achieved via clathrin-mediated endocytosis, followed by sorting into the luminal vesicles of MVBs and eventual delivery to lysosomes. Depletion of ESCRT-I and some ESCRT-III components interferes with this sorting and allows recycling of MHC class I to the cell surface. Depletion of ESCRT-II...
Articles
Biochem Soc Trans (2008) 36 (6): 1472-1477.
Published: 19 November 2008
... growth factor receptors. Finally, galectin–glycan lattices can determine receptor residency time by inhibiting endocytosis of glycoprotein receptors from the cell surface, thus modulating the magnitude or duration of signalling from the cell surface. This paper reviews recent evidence in vitro and in...
Articles
Biochem Soc Trans (2008) 36 (6): 1272-1276.
Published: 19 November 2008
... cells expressing PrP c to Cu 2+ results in the rapid endocytosis of the protein. First, PrP c translocates laterally out of detergent-resistant lipid rafts into detergent-soluble regions of the plasma membrane, then it is internalized through clathrin-coated pits. The extreme N-terminal region of PrP c...
Articles
Biochem Soc Trans (2008) 36 (5): 791-796.
Published: 19 September 2008
... several proteasome-independent functions in membrane protein trafficking, including a role in the ubiquitination of most plasma membrane proteins, leading to their endocytosis. Rsp5p is also required for the ubiquitination of endosomal proteins, leading to their sorting to the internal vesicles of MVBs...
Articles
Biochem Soc Trans (2007) 35 (5): 1055-1059.
Published: 25 October 2007
... subsequent ER exit. The resultant decrease in the cell-surface density of the channel could explain the disease phenotype. Two mutations, Y330C and F333I, reported in patients with NDM, disrupted an endocytic traffic signal, thereby impairing CCV (clathrin-coated vesicle) formation and endocytosis. The...
Articles
Biochem Soc Trans (2007) 35 (5): 1088-1091.
Published: 25 October 2007
... ). 2 Present address: Department of Biology (Area 9), University of York, PO Box 373, York YO10 5YW, U.K. 20 7 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 calcium endocytosis endosome lysosome mucolipin multivesicular body The acid lumen of...
Articles
Biochem Soc Trans (2007) 35 (4): 775-779.
Published: 20 July 2007
... glycosaminoglycans and are internalized by endocytosis, although the detailed mechanisms involved remain controversial. Sequestration and degradation in endocytic vesicles severely limits the efficiency of cytoplasmic and/or nuclear delivery of CPP-conjugated material. Re-routing the splicing machinery by using...
Articles
Biochem Soc Trans (2007) 35 (4): 784-787.
Published: 20 July 2007
... Journal compilation © 2007 Biochemical Society 2007 cell-penetrating peptide (CPP) arginine-rich peptide endocytosis macropinocytosis heparan sulfate proteoglycan (HSPG) membrane translocation Intracellular delivery using CPPs (cell-penetrating peptides) has now become a major topic in...
Articles
Biochem Soc Trans (2007) 35 (4): 767-769.
Published: 20 July 2007
... later. 1 To whom correspondence should be addressed (email J.Howl@wlv.ac.uk ). 16 5 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 endocytosis oligonucleotide penetratin transactivator of transcription (Tat) therapeutics translocation The...
Articles
Biochem Soc Trans (2007) 35 (1): 53-55.
Published: 22 January 2007
... translocate through the cell membrane by a non-endocytotic mechanism which has recently been re-evaluated. Basic-amino-acid-rich CPPs first interact with cell-surface proteoglycans before being internalized by endocytosis. Sequestration and degradation in endocytotic vesicles severely limits the cytoplasmic...
Articles
Biochem Soc Trans (2007) 35 (1): 68-71.
Published: 22 January 2007
... improvement, and better defining the mechanism of entry in relation to eventual transfection efficiency could be part of such a strategy. Endocytosis is the major pathway of entry, but the relative contribution of distinct endocytic pathways, including clathrin- and caveolae-mediated endocytosis and/or...
Articles
Biochem Soc Trans (2006) 34 (5): 754-756.
Published: 25 October 2006
... sorting. 1 To whom correspondence should be addressed (email urbe@liverpool.ac.uk ). 14 6 2006 © 2006 The Biochemical Society 2006 associated molecule with the Src homology 3 domain of signal transducing adapter molecule (AMSH) endocytosis epidermal growth factor (EGF) signal...
Articles
Biochem Soc Trans (2006) 34 (6): 1024-1027.
Published: 25 October 2006
... homology 2) domain-containing phosphatase-1] and SHP-2. In addition, the ITIMs of CD33-related siglecs can suppress siglec-dependent adhesion of sialylated ligands and mediate endocytosis. Siglec-H is a recently characterized murine CD33-related endocytic receptor that lacks intrinsic tyrosine-based...
Articles
Biochem Soc Trans (2006) 34 (1): 77-80.
Published: 20 January 2006
... Molecular Cell Biology, University College London, London WC1E 6BT, U.K. (email Giovanni.Lesa@ucl.ac.uk ). 9 8 2005 © 2006 The Biochemical Society 2006 Caenorhabditis elegans endocytosis nervous system neurotransmitter polyunsaturated fatty acid (PUFA) synaptic vesicle...
Articles
Biochem Soc Trans (2005) 33 (6): 1285-1289.
Published: 26 October 2005
...V. Haucke Endocytosis of transmembrane receptors largely occurs via clathrin-coated vesicles that bud from the plasma membrane and deliver their cargo to the endosomal system for recycling or degradation. PIs (phosphoinositides) control the timing and localization of endocytic membrane trafficking...
Articles
Biochem Soc Trans (2005) 33 (6): 1276-1278.
Published: 26 October 2005
...-ribosylation factor (Arf) clathrin-independent endocytosis endocytosis Golgi membrane traffic phosphoinositide The Arf (ADP-ribosylation factor) family of GTP-binding proteins are conserved, low molecular mass Ras-related GTPases involved in regulation of membrane traffic and organelle structure...
Articles
Biochem Soc Trans (2005) 33 (4): 606-608.
Published: 01 August 2005
...D. Poteryaev; A. Spang Caenorhabditis elegans has recently been used as an attractive model system to gain insight into mechanisms of endocytosis in multicellular organisms. A combination of forward and reverse genetics has identified a number of new membrane trafficking factors. Most of them have...
Articles
Biochem Soc Trans (2004) 32 (6): 1040-1044.
Published: 26 October 2004
... © 2004 The Biochemical Society 2004 cell signalling endocytosis G-protein-coupled receptor small G-protein trafficking Heterotrimeric GPCRs (G-protein-coupled receptors) form the largest group of integral membrane receptor proteins and mediate diverse physiological processes, including...
Articles
Biochem Soc Trans (2004) 32 (6): 1072-1074.
Published: 26 October 2004
...M.F. Ross; M.P. Murphy CPPs (cell-penetrating peptides) facilitate cellular uptake of covalently attached macromolecules, through an as yet controversial mechanism that either involves direct membrane passage or a type of endocytosis. We investigated the potential of the CPPs penetratin and Tat to...
Articles
Biochem Soc Trans (2004) 32 (5): 769-773.
Published: 26 October 2004
... be addressed (email peter.mcpherson@mcgill.ca ). 21 6 2004 © 2004 The Biochemical Society 2004 adaptor protein 1 (AP-1) AP-2 endocytosis enthoprotin epsinR liquid chromatography quadrupole time-of-flight (LC-Q-TOF) NECAP The sequencing of the human genome and the...
Articles
Biochem Soc Trans (2004) 32 (5): 685-688.
Published: 26 October 2004
... Biochemical Society 2004 actin endocytosis membrane traffic myosin optical tweezer Since movement is such a vital part of life at every level, eukaryotic cells have developed highly specialized methods of transport and movement to function as efficiently as possible. For example, vesicles...
Articles
Biochem Soc Trans (2004) 32 (1): 1-14.
Published: 01 February 2004
...D.J. Owen Clathrin-mediated endocytosis is the major process by which transmembrane proteins are internalized from the cell's limiting membrane into the first compartment of the endosomal system, the early endosome. From here, these transmembrane cargo proteins, which are of widely varying type and...
Articles
Biochem Soc Trans (2003) 31 (6): 1178-1181.
Published: 01 December 2003
...I. Dikic Activated EGF (epidermal growth factor) receptors are removed from the cell surface via endocytosis and subsequent degradation in the lysosome. This ultimately attenuates EGF receptor signals and diminishes the level of cell activation. The mechanisms underlying the EGF receptor down...
Articles
Biochem Soc Trans (2003) 31 (4): 819-823.
Published: 01 August 2003
... few years, the application of TIR-FM to membrane trafficking events in both non-excitable and excitable cells has been an area of notable expansion and fruition. This review gives a brief overview of that literature, with emphasis on the study of the regulation of exocytosis and endocytosis in...
Articles
Biochem Soc Trans (2001) 29 (4): 472-475.
Published: 01 August 2001
... endocytosis endosome phosphoinositide signal transduction AMSH, associated molecule with the SH3 domain of STAM EGF, epidermal growth factor GM-CSF, granulocyte/macrophage colony-stimulating factor HGF, hepatocyte growth factor Hrs, HGF-regulated tyrosine kinase substrate ITAM, immunotyrosine...
Articles
Biochem Soc Trans (2001) 29 (4): 480-484.
Published: 01 August 2001
...-containing protein, She. Activation of EGFRs by ligand also triggers rapid endocytosis of EGF-receptor complexes. To analyse the spatial and temporal regulation of EGFR interactions with SH2 domains in living cells, we have combined imaging microscopy with a modified method of measuring fluorescence...
Articles
Biochem Soc Trans (2001) 29 (4): 488-493.
Published: 01 August 2001
... ) 26 2 2001 © 2001 Biochemical Society 2001 degradation EGF receptor endocytosis lysosome ubiquitination EGF, epidermal growth factor GH, growth hormone GHR, growth hormone receptor UbE, ubiquitin-dependent endocytosis Biochemical Society Transactions (200 I ) Volume 29...