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Keywords: endocytosis
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Articles
Biochem Soc Trans (2024) 52 (4): 1703–1713.
Published: 02 August 2024
...Emily T. Chan; Cömert Kural Evading programmed cell death (PCD) is a hallmark of cancer that allows tumor cells to survive and proliferate unchecked. Endocytosis, the process by which cells internalize extracellular materials, has emerged as a key regulator of cell death pathways in cancer. Many...
Articles
Biochem Soc Trans (2024) 52 (4): 1785–1794.
Published: 27 June 2024
... uptake (∼90%) is due to macropinocytosis, with the residue probably due to clathrin-mediated endocytosis. Two different genetic backgrounds were used in these experiments: close to wild-type (DdB) with intact NF1 and low fluid uptake, which is greatly stimulated by deletion of NF1 or expression...
Articles
Biochem Soc Trans (2024) 52 (1): 1–13.
Published: 04 January 2024
...Mubashir Mintoo; Vinodh Rajagopalan; John P. O'Bryan Intersectin (ITSN) is a multi-domain scaffold protein with a diverse array of functions including regulation of endocytosis, vesicle transport, and activation of various signal transduction pathways. There are two ITSN genes located...
Articles
Biochem Soc Trans (2024) 52 (1): 291–299.
Published: 04 January 2024
... Society 2024 Correspondence: Erika Isono ( [email protected] ) Arabidopsis thaliana DUB endocytosis ubiquitin Plants are sessile organisms that need to adapt to local and global environmental changes in their habitat. For the perception of these changes and the timely...
Articles
Biochem Soc Trans (2023) 51 (2): 579–585.
Published: 09 March 2023
... trafficking does macropinocytosis make, relative to other forms of endocytosis? This question remains unanswered as does the question of whether specific surface receptors are preferentially trafficked by macropinocytosis. Specific trafficking could be co-ordinated, for example, by membrane lipid composition...
Articles
Biochem Soc Trans (2022) 50 (4): 1157–1167.
Published: 12 August 2022
... in cellular physiology for the study of vesicle fusion and endocytosis. In this review, we will explore the power of stimulated emission depletion (STED) and confocal microscopy in combination with various labeling techniques in real-time observation of the membrane transformation of fusion and endocytosis...
Articles
Biochem Soc Trans (2021) 49 (6): 2841–2851.
Published: 16 November 2021
... 25 10 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 endocytosis Epstein Barr virus exocytosis major histocompatibility complex T-cells viral particle release Autophagy describes at least three eukaryotic pathways...
Articles
Articles
Biochem Soc Trans (2018) 46 (3): 565–576.
Published: 20 April 2018
...Claudia Hinze; Emmanuel Boucrot Extracellular macromolecules, pathogens and cell surface proteins rely on endocytosis to enter cells. Key steps of endocytic carrier formation are cargo molecule selection, plasma membrane folding and detachment from the cell surface. While dedicated proteins mediate...
Articles
Biochem Soc Trans (2017) 45 (2): 489–497.
Published: 13 April 2017
... is then released into the cytoplasm. After translocation to the nucleus, the viral DNA is uncoated and enters the nucleus. HPV is internalised via CD151-dependent endocytosis leading to virus accumulation in CD63-positive endosomes. Next, complex formation of CD63 and syntenin-1 regulates endosomal maturation...
Articles
Biochem Soc Trans (2016) 44 (5): 1347–1354.
Published: 19 October 2016
... will summarise what is known about the molecular mechanisms mediating ECM endocytosis and how this process impacts on diseases, such as fibrosis and cancer. cancer cell invasion ECM remodelling ECM turnover endocytosis extracellular matrix The extracellular matrix (ECM) is a complex three...
Articles
Biochem Soc Trans (2016) 44 (2): 474–478.
Published: 11 April 2016
... recycling deubiquitination endocytosis yeast Organelle Crosstalk in Membrane Dynamics and Cell Signalling: Held at Carlton Hotel, Edinburgh, U.K., 26–29 October 2015 References 1 Goldstein J.L. Brown M.S. Anderson R.G. Russell D.W. Schneider W.J. Receptor...
Articles
Biochem Soc Trans (2015) 43 (3): 471–475.
Published: 01 June 2015
... functions, including the regulation of DNA repair, endocytosis, macroautophagy, protein activity and proteasomal degradation. Canonically, Lys 48 -linked polyubiquitin chains target substrates for proteasomal degradation, whereas monoubiquitination and Lys 63 -linked polyubiquitin chains have been linked...
Articles
Biochem Soc Trans (2015) 43 (3): 390–395.
Published: 01 June 2015
... alters a variety of intracellular vesicular trafficking steps including endocytosis, autophagy, retromer-mediated trafficking from late endosomes to the trans -Golgi complex, lysosome size/positioning and Golgi integrity [ 12 , 15 – 20 ] ( Figure 2 ). Thus, LRRK2 may modulate a variety of targets...
Articles
Biochem Soc Trans (2014) 42 (1): 195–200.
Published: 23 January 2014
... adhesion. Loss of TJs has been linked to the pathogenesis of many diseases. The present review focuses on the role of vesicle trafficking in regulation of TJs, in particular trafficking of the TJ protein occludin. We examine how endocytosis and endosomal recycling modulate occludin localization under...
Articles
Biochem Soc Trans (2013) 41 (6): 1562–1568.
Published: 20 November 2013
... to death, especially in inherited sphingolipid storage diseases. IMs are formed during endocytosis and their lipid composition is adjusted for degradation. Their cholesterol content, which stabilizes membranes, decreases and the level of negatively charged BMP, which stimulates sphingolipid degradation...
Articles
Biochem Soc Trans (2012) 40 (6): 1368–1372.
Published: 21 November 2012
... to several kind of genetic or acquired diseases [ 10 ]. 1 To whom correspondence should be addressed (email [email protected] ). 2 8 2012 © 2012 The Authors Journal 2012 autophagy Charcot–Marie–Tooth disease endocytosis peripheral neuropathy Rab7 Rab7a Figure...
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Biochem Soc Trans (2012) 40 (6): 1404–1408.
Published: 21 November 2012
...Shreya Mitra; Kwai W. Cheng; Gordon B. Mills Derailed endocytosis is a hallmark of cancer. The endocytic pathway, as demonstrated by our laboratory, is a frequent target of genomic aberrations in cancer and plays a critical role in the maintenance of cellular polarity, stem cell function...
Articles
Biochem Soc Trans (2012) 40 (5): 1117–1122.
Published: 19 September 2012
... compilation © 2012 Biochemical Society 2012 cytoskeleton endocytosis exocytosis leucine-rich repeat kinase 2 (LRRK2) PD (Parkinson's disease) is the second most common neurodegenerative disorder after Alzheimer's disease, affecting more than 1 million people in North America and more than 4...
Articles
Biochem Soc Trans (2010) 38 (6): 1417–1419.
Published: 24 November 2010
... ). 23 9 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 endocytosis endosome lysosome pathogen phagocytosis phagolysosome How a pathogen manipulates the host is an area of intense research, but identifying the targets of the pathogen proteins can...
Articles
Biochem Soc Trans (2010) 38 (6): 1432–1435.
Published: 24 November 2010
... additional homologues are TRPML2 and TRPML3 comprising the TRPML subgroup in the TRP superfamily. The three proteins play apparently key roles along the endocytosis process, and thus their cellular localization varies among the different group members. Thus TRPML1 is localized exclusively to late endosomes...
Articles
Biochem Soc Trans (2010) 38 (6): 1413–1416.
Published: 24 November 2010
.... Role of HRB in clathrin-dependent endocytosis J. Biol. Chem. 2008 283 34365 34373 17 Burgo A. Sotirakis E. Simmler M.C. Verraes A. Chamot C. Simpson J.C. Lanzetti L. Proux-Gillardeaux V. Galli T. Role of Varp, a Rab21 exchange factor and TI-VAMP/VAMP7...
Articles
Biochem Soc Trans (2010) 38 (3): 797–806.
Published: 24 May 2010
...Sebastian Y. Bednarek; Steven K. Backues Two separate families of Arabidopsis dynamin-related proteins, DRP1 and DRP2, have been implicated in clathrin-mediated endocytosis and cell plate maturation during cytokinesis. The present review summarizes the current genetic, biochemical and cell...
Articles
Biochem Soc Trans (2010) 38 (1): 187–191.
Published: 19 January 2010
... characterized these proteins using a combination of biochemical, imaging, structural and genetic techniques. These studies provide valuable information on binding partners, structure and dynamics of HIP1/HIP1R/Sla2p. In general, all suggest a role in CME (clathrin-mediated endocytosis) for the three proteins...
Articles
Biochem Soc Trans (2010) 38 (1): 181–186.
Published: 19 January 2010
...Arndt Pechstein; Oleg Shupliakov; Volker Haucke During neurotransmitter release, SVs (synaptic vesicles) fuse at the active zone and are recovered predominantly via clathrin-mediated endocytosis at the presynaptic compartment surrounding the site of release, referred to as the periactive zone. Exo...
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Articles
Biochem Soc Trans (2009) 37 (6): 1184–1188.
Published: 19 November 2009
... pathways to cellular events. 1 To whom correspondence should be addressed (email [email protected] ). 28 7 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 angiogenesis endocytosis intracellular trafficking vascular endothelial growth factor (VEGF...
Articles
Biochem Soc Trans (2009) 37 (5): 1027–1031.
Published: 21 September 2009
... compilation © 2009 Biochemical Society 2009 Charcot–Marie–Tooth disease endocytosis neurite outgrowth neurodegeneration Rab7 Rab protein The CMT disease (Charcot–Marie–Tooth disease) is one of the most common groups of inherited neuropathies that affect peripheral nerves [ 1 ]. Peripheral...
Articles
Biochem Soc Trans (2009) 37 (5): 1072–1076.
Published: 21 September 2009
... on the role of different trafficking pathways in epithelial cell migration, including clathrin-mediated endocytosis, caveolar endocytosis, exocytosis of biosynthetic cargo, ‘short-loop’ and ‘long-loop’ endosomal recycling. The process of migration involves both generation of a motile phenotype and its...
Articles
Biochem Soc Trans (2009) 37 (5): 1019–1021.
Published: 21 September 2009
... replaces VAMP7. VAMP7 is also required for lysosome fusion with the plasma membrane where it forms a trans -SNARE complex with Syntaxin4 and SNAP23 (23 kDa synaptosome-associated protein) [ 13 ]. endocytosis endosome lysosome multivesicular body vesicle-associated membrane protein 7 (VAMP7...
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Biochem Soc Trans (2009) 37 (1): 178–180.
Published: 20 January 2009
... expressing K3 is achieved via clathrin-mediated endocytosis, followed by sorting into the luminal vesicles of MVBs and eventual delivery to lysosomes. Depletion of ESCRT-I and some ESCRT-III components interferes with this sorting and allows recycling of MHC class I to the cell surface. Depletion of ESCRT-II...
Articles
Biochem Soc Trans (2008) 36 (6): 1472–1477.
Published: 19 November 2008
... receptors. Finally, galectin–glycan lattices can determine receptor residency time by inhibiting endocytosis of glycoprotein receptors from the cell surface, thus modulating the magnitude or duration of signalling from the cell surface. This paper reviews recent evidence in vitro and in vivo for critical...
Articles
Biochem Soc Trans (2008) 36 (6): 1272–1276.
Published: 19 November 2008
... cells expressing PrP c to Cu 2+ results in the rapid endocytosis of the protein. First, PrP c translocates laterally out of detergent-resistant lipid rafts into detergent-soluble regions of the plasma membrane, then it is internalized through clathrin-coated pits. The extreme N-terminal region of PrP c...
Articles
Biochem Soc Trans (2008) 36 (5): 791–796.
Published: 19 September 2008
... several proteasome-independent functions in membrane protein trafficking, including a role in the ubiquitination of most plasma membrane proteins, leading to their endocytosis. Rsp5p is also required for the ubiquitination of endosomal proteins, leading to their sorting to the internal vesicles of MVBs...
Articles
Biochem Soc Trans (2007) 35 (5): 1088–1091.
Published: 25 October 2007
... ). 2 Present address: Department of Biology (Area 9), University of York, PO Box 373, York YO10 5YW, U.K. 20 7 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 calcium endocytosis endosome lysosome mucolipin multivesicular body The luminal ionic...
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Biochem Soc Trans (2007) 35 (5): 1055–1059.
Published: 25 October 2007
... and subsequent ER exit. The resultant decrease in the cell-surface density of the channel could explain the disease phenotype. Two mutations, Y330C and F333I, reported in patients with NDM, disrupted an endocytic traffic signal, thereby impairing CCV (clathrin-coated vesicle) formation and endocytosis...
Articles
Biochem Soc Trans (2007) 35 (4): 767–769.
Published: 20 July 2007
... correspondence should be addressed (email [email protected] ). 16 5 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 endocytosis oligonucleotide penetratin transactivator of transcription (Tat) therapeutics translocation The identification and early...
Articles
Biochem Soc Trans (2007) 35 (4): 775–779.
Published: 20 July 2007
... glycosaminoglycans and are internalized by endocytosis, although the detailed mechanisms involved remain controversial. Sequestration and degradation in endocytic vesicles severely limits the efficiency of cytoplasmic and/or nuclear delivery of CPP-conjugated material. Re-routing the splicing machinery by using...
Articles
Biochem Soc Trans (2007) 35 (4): 784–787.
Published: 20 July 2007
... significant involvement of endocytosis has been established, internalization of the peptides is also observed at 4°C, where endocytic pathways would not function. Diffuse cytosolic staining, suggestive of direct membrane translocation of arginine-rich peptides, is observed in several cell types treated...
Articles
Biochem Soc Trans (2007) 35 (1): 53–55.
Published: 22 January 2007
... to translocate through the cell membrane by a non-endocytotic mechanism which has recently been re-evaluated. Basic-amino-acid-rich CPPs first interact with cell-surface proteoglycans before being internalized by endocytosis. Sequestration and degradation in endocytotic vesicles severely limits the cytoplasmic...
Articles
Biochem Soc Trans (2007) 35 (1): 68–71.
Published: 22 January 2007
... improvement, and better defining the mechanism of entry in relation to eventual transfection efficiency could be part of such a strategy. Endocytosis is the major pathway of entry, but the relative contribution of distinct endocytic pathways, including clathrin- and caveolae-mediated endocytosis...
Articles
Biochem Soc Trans (2006) 34 (6): 1024–1027.
Published: 25 October 2006
... homology 2) domain-containing phosphatase-1] and SHP-2. In addition, the ITIMs of CD33-related siglecs can suppress siglec-dependent adhesion of sialylated ligands and mediate endocytosis. Siglec-H is a recently characterized murine CD33-related endocytic receptor that lacks intrinsic tyrosine-based...
Articles
Biochem Soc Trans (2006) 34 (5): 754–756.
Published: 25 October 2006
... To whom correspondence should be addressed (email [email protected] ). 14 6 2006 © 2006 The Biochemical Society 2006 associated molecule with the Src homology 3 domain of signal transducing adapter molecule (AMSH) endocytosis epidermal growth factor (EGF) signal transducing...
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Biochem Soc Trans (2006) 34 (1): 77–80.
Published: 20 January 2006
... for Molecular Cell Biology, University College London, London WC1E 6BT, U.K. (email [email protected] ). 9 8 2005 © 2006 The Biochemical Society 2006 Caenorhabditis elegans endocytosis nervous system neurotransmitter polyunsaturated fatty acid (PUFA) synaptic vesicle...
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Biochem Soc Trans (2005) 33 (6): 1285–1289.
Published: 26 October 2005
...V. Haucke Endocytosis of transmembrane receptors largely occurs via clathrin-coated vesicles that bud from the plasma membrane and deliver their cargo to the endosomal system for recycling or degradation. PIs (phosphoinositides) control the timing and localization of endocytic membrane trafficking...
Articles
Biochem Soc Trans (2005) 33 (6): 1276–1278.
Published: 26 October 2005
...) clathrin-independent endocytosis endocytosis Golgi membrane traffic phosphoinositide Future studies will focus on the function of PIP 2 in this endocytic pathway, which proteins are recruited to the endosomal membranes by PIP 2 and by what mechanism PIP 2 is lost from the endosome. Another...
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Biochem Soc Trans (2005) 33 (4): 606–608.
Published: 01 August 2005
...D. Poteryaev; A. Spang Caenorhabditis elegans has recently been used as an attractive model system to gain insight into mechanisms of endocytosis in multicellular organisms. A combination of forward and reverse genetics has identified a number of new membrane trafficking factors. Most of them have...
Articles
Biochem Soc Trans (2004) 32 (5): 769–773.
Published: 26 October 2004
... [email protected] ). 21 6 2004 © 2004 The Biochemical Society 2004 adaptor protein 1 (AP-1) AP-2 endocytosis enthoprotin epsinR liquid chromatography quadrupole time-of-flight (LC-Q-TOF) NECAP The sequencing of the human genome and the genomes of various experimental model...
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Biochem Soc Trans (2004) 32 (5): 685–688.
Published: 26 October 2004
... moving along the actin filament network [ 1 ]. actin endocytosis membrane traffic myosin optical tweezer 1 These authors have contributed equally to this work. 2 To whom correspondence should be addressed (email [email protected] ). 21 6 2004 © 2004...
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Biochem Soc Trans (2004) 32 (6): 1072–1074.
Published: 26 October 2004
...M.F. Ross; M.P. Murphy CPPs (cell-penetrating peptides) facilitate cellular uptake of covalently attached macromolecules, through an as yet controversial mechanism that either involves direct membrane passage or a type of endocytosis. We investigated the potential of the CPPs penetratin and Tat...