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Keywords: endoplasmic reticulum
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Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (4): 1617–1629.
Published: 27 June 2024
... intricate of all cell types. Yet, within the neuron lies an organelle whose architecture adds another level to this morphological sophistication — the endoplasmic reticulum (ER). Neuronal ER is abundant in the cell body and extends to distant axonal terminals and postsynaptic dendritic spines. It also...
Articles
Mammalian cargo receptors for endoplasmic reticulum-to-Golgi transport: mechanisms and interactions
Open Access
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (3): 971–981.
Published: 19 June 2023
...Yuan Zhang; Vishal Srivastava; Bin Zhang Proteins that are destined to enter the secretory pathway are synthesized on the rough endoplasmic reticulum (ER) and then translocated into the ER lumen, where they undergo posttranslational modifications, folding, and assembly. After passing a quality...
Articles
New discoveries in ER–mitochondria communication
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (2): 571–577.
Published: 09 March 2023
...Margret Helene Bülow; Julia Sellin The study of endoplasmic reticulum (ER)-mitochondria communication is a vast and expanding field with many novel developments in the past few years. In this mini-review, we focus on several recent publications that identify novel functions of tether complexes...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (5): 1389–1402.
Published: 28 October 2022
... The Author(s) 2022 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . aging endoplasmic reticulum inter-organelle longevity mitochondria Over...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (5): 2199–2210.
Published: 19 October 2021
... the pathways of selective autophagy, two aspects of mitophagy will be covered: (i) How does a machinery normally working in association with the endoplasmic reticulum (ER) to make an autophagosome can also do so at a site distinct from the ER such as on the surface of the targeted cargo? and (ii) how does...
Articles
ER functions are exploited by viruses to support distinct stages of their life cycle
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (5): 2173–2184.
Published: 29 October 2020
...Yu-Jie Chen; Parikshit Bagchi; Billy Tsai The endoplasmic reticulum (ER), with its expansive membranous system and a vast network of chaperones, enzymes, sensors, and ion channels, orchestrates diverse cellular functions, ranging from protein synthesis, folding, secretion, and degradation to lipid...
Articles
Tyrosine kinase signaling in and on the endoplasmic reticulum
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (1): 199–205.
Published: 17 February 2020
... little attention has been dedicated to signaling at endomembranes. In this review, I will discuss recent evidence that we obtained on signaling of tyrosine kinases at the surface of the endoplasmic reticulum (ER), as well as in the lumen of this organelle. I will discuss how tyrosine kinase signaling...
Articles
ER-Golgi membrane contact sites
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (1): 187–197.
Published: 17 February 2020
... ( [email protected] ) 6 11 2019 20 1 2020 24 1 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 endoplasmic reticulum golgi apparatus membrane contact sites phosphatidylinositol Membrane contact sites (MCSs...
Articles
Eat it right: ER-phagy and recovER-phagy
Open Access
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (3): 699–706.
Published: 25 May 2018
...Marisa Loi; Ilaria Fregno; Concetta Guerra; Maurizio Molinari The endoplasmic reticulum (ER) is the site of protein, lipid, phospholipid, steroid and oligosaccharide synthesis and modification, calcium ion storage, and detoxification of endogenous and exogenous products. Its volume (and activity...
Articles
Non-vesicular lipid trafficking at the endoplasmic reticulum–mitochondria interface
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (2): 437–452.
Published: 27 March 2018
... to maintain a defined protein and lipid composition in both their membranes. The maintenance of mitochondrial membrane identity requires a selective and regulated transport of specific lipids from/to the endoplasmic reticulum (ER) and across the mitochondria outer and inner membranes. Since...
Articles
Autophagy in the context of the cellular membrane-trafficking system: the enigma of Atg9 vesicles
Open Access
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2017) 45 (6): 1323–1331.
Published: 17 November 2017
... by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . autophagy endoplasmic reticulum trafficking The discovery of the omegasome was a major breakthrough in autophagy research with respect...
Articles
Touché! STARD3 and STARD3NL tether the ER to endosomes
Available to Purchase
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (2): 493–498.
Published: 11 April 2016
... complexes. STARD3 [StAR (steroidogenic acute regulatory protein)-related lipid transfer domain-3] and its close paralogue STARD3NL (STARD3 N-terminal like) are involved in the formation of contacts between late-endosomes and the endoplasmic reticulum (ER). The lipid transfer protein (LTP) STARD3...
Articles
Phosphoinositides in membrane contact sites
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (2): 425–430.
Published: 11 April 2016
... organellar architecture during the transfer process. Even though the molecular compositions of membrane contact sites are diverse, it is striking that several of these sites, including contact sites between the endoplasmic reticulum (ER) and endosomes, Golgi and the plasma membrane (PM), and contact sites...
Articles
Regulation of calcium and phosphoinositides at endoplasmic reticulum–membrane junctions
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (2): 467–473.
Published: 11 April 2016
...Eamonn J. Dickson; Jill B. Jensen; Bertil Hille Effective cellular function requires both compartmentalization of tasks in space and time, and coordination of those efforts. The endoplasmic reticulum's (ER) expansive and ramifying structure makes it ideally suited to serve as a regulatory platform...
Articles
When under pressure, get closer: PERKing up membrane contact sites during ER stress
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (2): 499–504.
Published: 11 April 2016
...Alexander R. van Vliet; Patrizia Agostinis The endoplasmic reticulum (ER) is the main hub of cellular Ca 2+ signalling and protein synthesis and folding. The ER moreover is the central player in the formation of contact sites with other organelles and structures, including mitochondria, plasma...
Articles
Ca 2+ dialogue between acidic vesicles and ER
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (2): 546–553.
Published: 11 April 2016
... ) and IP 3 receptor (IP 3 R) on the endoplasmic reticulum (ER). A less understood, parallel Ca 2+ signalling cascade is that involving the messenger nicotinic acid adenine dinucleotide phosphate (NAADP) that couples to Ca 2+ release from acidic Ca 2+ stores [e.g. endo-lysosomes, secretory vesicles...
Articles
Phosphatidylinositol and phosphatidic acid transport between the ER and plasma membrane during PLC activation requires the Nir2 protein
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (1): 197–201.
Published: 09 February 2016
... (PtdIns) via sequential phosphorylation by PtdIns 4-kinases and phosphatidylinositol 4-phosphate (PtdIns4P) 5-kinases. Since PtdIns is synthesized in the endoplasmic reticulum (ER) and PtdIns(4,5)P 2 is generated in the PM, it has been postulated that PtdIns transfer proteins (PITPs) provide the means...
Articles
Principle of duality in phospholipids: regulators of membrane morphology and dynamics
Available to PurchaseBanafshé Larijani, Fadi Hamati, Aupola Kundu, Gary C. Chung, Marie-Charlotte Domart, Lucy Collinson, Dominic L. Poccia
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (5): 1335–1342.
Published: 18 September 2014
... drive morphology and dynamics (fusion) of subcellular compartments which should instead be considered proteolipid events. We reiterate the important roles of phospholipids, specifically phosphoinositides and their derivatives, in the maintenance of the proper morphology of the endoplasmic reticulum (ER...
Articles
Redox regulation in the endoplasmic reticulum
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 905–908.
Published: 11 August 2014
... the endoplasmic reticulum: too reducing and disulfides will not form, too oxidizing and non-native disulfides will not be resolved. How the endoplasmic reticulum maintains the correct redox balance is unknown. Although we have a good appreciation of the processes leading to a more oxidizing environment, our...
Articles
Structural organization of signalling to and from IP 3 receptors
Available to PurchaseColin W. Taylor, Stephen C. Tovey, Ana M. Rossi, Cristina I. Lopez Sanjurjo, David L. Prole, Taufiq Rahman
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (1): 63–70.
Published: 23 January 2014
... is likely to be spatially organized. © The Authors Journal compilation © 2014 Biochemical Society 2014 calcium signalling cAMP endoplasmic reticulum inositol 1 4 5-trisphosphate receptor (IP 3 receptor) lysosome ryanodine receptor Thirty years ago, and in the face of a commonly...
Articles
Small GTPases and Brucella entry into the endoplasmic reticulum
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (6): 1348–1352.
Published: 21 November 2012
... the ER (endoplasmic reticulum) to create a replicating niche called the BCV ( Brucella -containing vacuole). The ER is a suitable strategic place for pathogenic Brucella . Indeed, bacteria can be hidden from host cell defences to persist within the host, and they can take advantage of the membrane...
Articles
Morphological and functional aspects of STIM1-dependent assembly and disassembly of store-operated calcium entry complexes
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (1): 112–118.
Published: 19 January 2012
...Wei-Wei Shen; Nicolas Demaurex The SOCE (store-operated Ca 2+ entry) pathway is a central component of cell signalling that links the Ca 2+ -filling state of the ER (endoplasmic reticulum) to the activation of Ca 2+ -permeable channels at the PM (plasma membrane). SOCE channels maintain a high free...
Articles
Farnesol-induced cell death in the filamentous fungus Aspergillus nidulans
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (5): 1544–1548.
Published: 21 September 2011
... endoplasmic reticulum farnesol reactive oxygen species (ROS) 8th International Meeting on Yeast Apoptosis: An Independent Meeting held at Keynes College, University of Kent, Canterbury, U.K., 2–6 May 2011. Organized and Edited by Paula Ludovico (University of Minho, Braga, Portugal). AIF...
Articles
Escape from stress granule sequestration: another way to drug resistance?
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (6): 1537–1542.
Published: 24 November 2010
... at the endoplasmic reticulum, follow the same pattern. By using a series of chimaeric transcripts, we have demonstrated that transcript localization at the endoplasmic reticulum bypasses the signals dictating stress granule sequestration. Polysome profile analyses and protein synthesis experiments indicate...
Articles
Networking in the endoplasmic reticulum
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (3): 747–753.
Published: 24 May 2010
...Lawrence R. Griffing The network of the ER (endoplasmic reticulum) is set up by cytoskeletal control of the movement and remodelling of polygonal rings of tubules, bundles of tubules and cisternal regions. We have developed a new image analysis tool, persistency mapping, to understand the framework...
Articles
Trafficking of the cellulose synthase complex in developing xylem vessels
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (3): 755–760.
Published: 24 May 2010
... endoplasmic reticulum Golgi body microtubule plant This work has benefited through the support of the Biotechnology and Biological Sciences Research Council [grant number 34/C19282], European Union (Renewall project), Wellcome Trust VIP award and a grant from The Gatsby Foundation. References...
Articles
RNA editing and its impact on GABA A receptor function
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1399–1403.
Published: 19 November 2009
... should be addressed (email [email protected] ). 4 8 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 adenosine deaminase that acts on RNA (ADAR) central nervous system (CNS) endoplasmic reticulum γ-aminobutyric acid type A receptor (GABA A receptor...
Articles
How and why does the endoplasmic reticulum move?
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (5): 961–965.
Published: 21 September 2009
...Becky Bola; Viki Allan The ER (endoplasmic reticulum) is a fascinating organelle that is highly dynamic, undergoing constant movement and reorganization. It has many key roles, including protein synthesis, folding and trafficking, calcium homoeostasis and lipid synthesis. It can expand in size when...
Articles
Visualization of protein interactions inside the secretory pathway
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 970–973.
Published: 25 October 2007
...B. Nyfeler; H.-P. Hauri The ER (endoplasmic reticulum) is a major protein folding and modification organelle. In its lumen, the ER processes a third of all newly synthesized proteins. To accomplish this task, numerous resident proteins capture the nascent and newly synthesized proteins...
Articles
TRPC1: a core component of store-operated calcium channels
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (1): 96–100.
Published: 22 January 2007
... the role of TRPC1 in SOCE and discuss how studies with TRPC1 provide an experimental basis for validating the mechanism of SOCE. 1 9 2006 © 2007 The Biochemical Society 2007 calcium-release-activated calcium channel (CRAC channel) calcium signalling endoplasmic reticulum regulatory...
Articles
Plasma membrane IP 3 receptors
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (5): 910–912.
Published: 25 October 2006
... be addressed (email [email protected] ). 19 6 2006 © 2006 The Biochemical Society 2006 endoplasmic reticulum inositol 1,4,5-trisphosphate receptor (IP 3 receptor) patch–clamp recording plasma membrane protein targeting store-operated Ca 2+ entry The most unexpected feature...
Articles
NAADP, a new intracellular messenger that mobilizes Ca 2+ from acidic stores
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (5): 922–926.
Published: 25 October 2006
... the relatively well-characterized IP 3 and ryanodine receptors. Furthermore, in the sea urchin egg, the NAADP-sensitive store appears to be separate from the endoplasmic reticulum and is most likely an acidic store. These findings have also been reinforced by similar findings in mammalian cells, and a unified...
Articles
Macromolecular assemblies regulate nonvesicular phosphatidylserine traffic in yeast
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (3): 404–408.
Published: 22 May 2006
...J.-Y. Choi; W.R. Riekhof; W.-I. Wu; D.R. Voelker PtdSer (phosphatidylserine) is synthesized in the endoplasmic reticulum and the related MAM (mitochondria-associated membrane), and transported to the PtdSer decarboxylases, Pds1p in the mitochondria, and Psd2p in the Golgi. Genetic and biochemical...
Articles
Lipid trafficking between the endoplasmic reticulum and the chloroplast
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (3): 395–398.
Published: 22 May 2006
... by photosynthesis. Lipid biosynthetic enzymes of different subcellular compartments participate in the biogenesis of the thylakoid membrane system. This process requires the extensive exchange of lipid precursors between the chloroplast and the ER (endoplasmic reticulum). The underlying lipid trafficking phenomena...
Articles
Endoplasmic reticulum generates calcium signalling microdomains around the nucleus and spindle in syncytial Drosophila embryos
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (3): 385–388.
Published: 22 May 2006
... calcium store is the ER (endoplasmic reticulum): the spatial organization of the ER during mitosis is important in defining a microdomain around the nucleus and mitotic spindle in early Drosophila embryos [Parry, McDougall and Whitaker (2005) J. Cell Biol. 171 , 47–59]. Nuclear divisions in syncytial...
Includes: Multimedia, Supplementary data
Articles
Moving Ca 2+ from the endoplasmic reticulum to mitochondria: is spatial intimacy enough?
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (3): 351–355.
Published: 22 May 2006
...G.A. Rutter A number of studies in recent years have demonstrated that the ER (endoplasmic reticulum) makes intimate contacts with mitochondria, the latter organelles existing both as individual organelles and occasionally as a more extensive interconnected network. Demonstrations that mitochondria...
Articles
Uptake and trafficking of exogenous sterols in Saccharomyces cerevisiae
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (3): 359–362.
Published: 22 May 2006
... of these pathways moves exogenous sterols from the plasma membrane to the endoplasmic reticulum in the yeast Saccharomyces cerevisiae . We have found that two classes of proteins play critical roles in this transport, ABC transporters (ATP-binding-cassette transporters) and oxysterol-binding protein-related...
Articles
Sterol trafficking between the endoplasmic reticulum and plasma membrane in yeast
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (3): 356–358.
Published: 22 May 2006
...D.P. Sullivan; H. Ohvo-Rekilä; N.A. Baumann; C.T. Beh; A.K. Menon We recently showed that transport of ergosterol from the ER (endoplasmic reticulum) to the sterol-enriched PM (plasma membrane) in yeast occurs by a non-vesicular (Sec18p-independent) mechanism that results in the equilibration...
Articles
Organization and functions of sphingolipid biosynthesis in yeast
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (3): 367–369.
Published: 22 May 2006
...H. Riezman Sphingolipids are important signalling molecules and thus it is very important to understand how they are generated. Sphingolipid biosynthesis shows a conserved compartmentalization in eukaryotic cells. Their synthesis begins in the endoplasmic reticulum and is completed in the Golgi...
Articles
Pathways for protein transport to seed storage vacuoles
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (5): 1016–1018.
Published: 26 October 2005
... and possible implications with respect to the working model for transport to storage vacuoles are discussed. dense vesicle endoplasmic reticulum plant secretion protein-storage vacuole protein transport vacuolar sorting signal Vacuoles are multifunctional organelles that can be regarded...
Articles
Oxidative protein folding in the mammalian endoplasmic reticulum
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (5): 655–658.
Published: 26 October 2004
...C.E. Jessop; S. Chakravarthi; R.H. Watkins; N.J. Bulleid Native disulphide bonds are essential for the structure and function of many membrane and secretory proteins. Disulphide bonds are formed, reduced and isomerized in the endoplasmic reticulum of mammalian cells by a family of oxidoreductases...
Articles
Catalysis of disulphide bond formation in the endoplasmic reticulum
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (5): 663–667.
Published: 26 October 2004
...L. Ellgaard Disulphide bonds are critical for the maturation and stability of secretory and cell-surface proteins. In eukaryotic cells, disulphide bonds are introduced in the ER (endoplasmic reticulum), where the redox conditions are optimal to support their formation. Yet, the correct pairing...
Articles
Proteomic analysis of the Arabidopsis cell wall reveals unexpected proteins with new cellular locations
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (3): 524–528.
Published: 01 June 2004
.... These included citrate synthase, which is known to be targeted to mitochondria, peroxisomes and glyoxysomes, and luminal binding protein, which is an ER (endoplasmic reticulum)-resident protein. Searches of the Arabidopsis database revealed that there are several genes encoding putative citrate synthase...
Articles
Organization of translocon complexes in ER membranes
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (6): 1253–1256.
Published: 01 December 2003
...A.V. Nikonov; G. Kreibich Protein translocation in the ER (endoplasmic reticulum) and N-glycosylation are fundamental processes essential for the normal functioning of eukaryotic cells. They are the initial steps in the intracellular pathway that are followed by secretory proteins and membrane...
Articles
How does the translocon differentiate between hydrophobic sequences that form part of either a GPI (glycosylphosphatidylinositol)-anchor signal or a stop transfer sequence?
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (6): 1257–1259.
Published: 01 December 2003
.... 1 To whom correspondence should be addressed (e-mail [email protected] ). 679th Meeting of the Biochemical Society held at the University of Essex, Colchester, 2–4 July 2003 5 June 2003 © 2003 Biochemical Society 2003 endoplasmic reticulum glycosylphosphatidylinositol...
Articles
Retrograde transport of toxins across the endoplasmic reticulum membrane
Available to PurchaseJ.M. Lord, E. Deeks, C.J. Marsden, K. Moore, C. Pateman, D.C. Smith, R.A. Spooner, P. Watson, L.M. Roberts
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (6): 1260–1262.
Published: 01 December 2003
... processes. In the case of ricin, the process inhibited is protein synthesis. In order to reach their cytosolic substrates, several toxins undergo retrograde transport to the ER (endoplasmic reticulum) before translocating across the ER membrane. To achieve this export, these toxins exploit the ERAD (ER...
Articles
Getting to the membrane: how is co-translational protein targeting to the endoplasmic reticulum regulated?
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (6): 1232–1237.
Published: 01 December 2003
...M.R. Pool Co-translational protein targeting to the endoplasmic reticulum requires the signal-recognition particle, its cognate receptor and the translocation channel. Co-ordination of the targeting process necessitates the interaction of these components with each other and with the ribosome...
Articles
Biogenesis of tail-anchored proteins
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (6): 1238–1242.
Published: 01 December 2003
... that tail-anchored proteins translocate their C-termini across the endoplasmic reticulum membrane by a mechanism different from that used for Sec61-dependent post-translational signal-peptide-driven translocation. Here we summarize recent results on the insertion of tail-anchored proteins and discuss...
Articles
Intramembrane proteolysis and post-targeting functions of signal peptides
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (6): 1243–1247.
Published: 01 December 2003
...B. Martoglio Signal sequences are the addresses of proteins destined for secretion. In eukaryotic cells, they mediate targeting to the endoplasmic reticulum membrane and insertion into the translocon. Thereafter, signal sequences are cleaved from the pre-protein and liberated into the endoplasmic...
Articles
Early events in the trafficking of N-methyl-d-aspartate (NMDA) receptors
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (4): 885–888.
Published: 01 August 2003
.... While these interactions have been most thoroughly studied with respect to the receptor at the synapse, the same proteins may also interact with the receptor much earlier in its biosynthetic pathway and play important roles in receptor trafficking from the endoplasmic reticulum to the synapse. 1...
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