... Cancer Research (1032) to E.M. and Wellcome Trust (215191/Z/19/Z) to B.S. The authors declare that there are no competing interests associated with the manuscript. ESCRT endosomal sorting complex required for transport HIF hypoxia-inducible factor ILVs intra luminal vesicles...

...Han Han; Christopher P. Hill The progression of ESCRT (Endosomal Sorting Complexes Required for Transport) pathways, which mediate numerous cellular membrane fission events, is driven by the enzyme Vps4. Understanding of Vps4 mechanism is, therefore, of fundamental importance in its own right...

... face of the endosome and generates vesicles that bud into the endosome lumen, but somehow escapes encapsulation itself. This machinery is termed the ESCRT (endosomal sorting complexes required for transport) pathway, a series of multi-protein complexes and accessory factors first identified in yeast...

... by Portland Press Limited on behalf of the Biochemical Society 2017 cell adhesion cell migration endosomal sorting protein kinase B Rab5 trafficking APPL1 integrates signaling cross-talk via multiple domains that mediate protein and lipid interactions [ 3 , 4 ]. The N-terminal BAR (Bin...

... published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . endosomal sorting lysosomes receptors trafficking vacuole The plant vacuole was first discovered in 1676 by a Dutch scientist Antonie van...

... are increasingly being linked with human disease. 1 To whom correspondence should be addressed (email [email protected] ) . 23 10 2014 © The Authors Journal compilation © 2015 Biochemical Society 2015 endosomal sorting post-synaptic density 95/discs large/zonula occludens...

... endosomal sorting motor protein Rab protein sorting nexin (SNX) Eukaryotic cells are compartmentalized into distinct organelles that are composed of specific cohorts of proteins and lipids. Precise transport mechanisms are therefore required to direct molecules to the right compartment...

...Jeremy Carlton The ESCRT (endosomal sorting complex required for transport) machinery is a group of multisubunit protein complexes conserved across phyla that are involved in a range of diverse cellular processes. ESCRT proteins regulate the biogenesis of MVBs (multivesicular bodies...