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Keywords: endosome
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Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (6): 2377–2386.
Published: 10 December 2020
... of complexity that actively opposes degradation. This review will summarise recent developments regarding the composition and regulation of the recycling machineries and their relationship with the degradative pathways of the endosome. 8 7 2020 29 10 2020 11 11 2020 © 2020 The Author(s...
Articles
Unveiling the cryo-EM structure of retromer
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (5): 2261–2272.
Published: 14 October 2020
...Mintu Chandra; Amy K. Kendall; Lauren P. Jackson Retromer (VPS26/VPS35/VPS29) is a highly conserved eukaryotic protein complex that localizes to endosomes to sort transmembrane protein cargoes into vesicles and elongated tubules. Retromer mediates retrieval pathways from endosomes to the trans...
Articles
To be more precise: the role of intracellular trafficking in development and pattern formation
Open Access
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (5): 2051–2066.
Published: 11 September 2020
... through the complex dynamic transport network between the plasma membrane–endosome–lysosome–Golgi–endoplasmic reticulum are much more well-studied. How the intracellular organisation of the cell and inter-organellar contacts aid in orchestrating trafficking, as well as signal interpretation and modulation...
Articles
Touché! STARD3 and STARD3NL tether the ER to endosomes
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (2): 493–498.
Published: 11 April 2016
... complexes. STARD3 [StAR (steroidogenic acute regulatory protein)-related lipid transfer domain-3] and its close paralogue STARD3NL (STARD3 N-terminal like) are involved in the formation of contacts between late-endosomes and the endoplasmic reticulum (ER). The lipid transfer protein (LTP) STARD3...
Articles
TPC: the NAADP discovery channel?
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (3): 384–389.
Published: 01 June 2015
.... 1 To whom correspondence should be addressed (email [email protected] ) . 12 11 2014 © The Authors Journal compilation © 2015 Biochemical Society 2015 NAADP TPC Ca 2+ lysosome endosome How Ca 2+ is sequestered into these acidic vesicles is unclear...
Articles
Arresting inflammation: contributions of plasma membrane and endosomal signalling to neuropeptide-driven inflammatory disease
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (1): 137–143.
Published: 29 January 2013
... of signalling by internalized receptors. Endosomal peptidases, such as ECE-1 (endothelin-converting enzyme-1), can degrade SP in acidified endosomes, which destabilizes signalosomes and allows receptors, freed from β-arrestins, to recycle and resensitize. By disassembling signalosomes, ECE-1 terminates β...
Articles
Triggering of Ca 2+ signals by NAADP-gated two-pore channels: a role for membrane contact sites?
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (1): 153–157.
Published: 19 January 2012
...-lymphocytes J. Biol. Chem. 2005 280 21394 21399 57 Bonifacino J.S. Traub L.M. Signals for sorting of transmembrane proteins to endosomes and lysosomes Annu. Rev. Biochem. 2003 72 395 447 58 Kinnear N.P. Boittin F.X. Thomas J.M. Galione A. Evans A.M...
Articles
Phosphoinositides and the regulation of tubular-based endosomal sorting
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (4): 839–850.
Published: 20 July 2011
..., whole-organism physiology and development. In the present paper, I give a personal view of the role played by phosphoinositides in regulating the function of the endosomal network, and, in so doing, highlight some of the basic properties through which phosphoinositides regulate cell function...
Articles
Endosome–lysosome fusion
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (6): 1413–1416.
Published: 24 November 2010
...J. Paul Luzio; Sally R. Gray; Nicholas A. Bright The delivery of endocytosed cargo to lysosomes occurs through kissing and direct fusion of late endosomes/MVBs (multivesicular bodies) and lysosomes. Live-cell and electron microscopy experiments together with cell-free assays have allowed us...
Articles
Manipulation of the host by pathogens to survive the lysosome
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (6): 1417–1419.
Published: 24 November 2010
... ). 23 9 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 endocytosis endosome lysosome pathogen phagocytosis phagolysosome How a pathogen manipulates the host is an area of intense research, but identifying the targets of the pathogen proteins can...
Articles
The role of ESCRT proteins in fusion events involving lysosomes, endosomes and autophagosomes
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (6): 1469–1473.
Published: 24 November 2010
...Daniel Metcalf; Adrian M. Isaacs ESCRT (endosomal sorting complex required for transport) proteins were originally identified for their role in delivering endocytosed proteins to the intraluminal vesicles of late-endosomal structures termed multivesicular bodies. Multivesicular bodies then fuse...
Articles
Endosomal sorting of AMPA receptors in hippocampal neurons
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (2): 460–465.
Published: 22 March 2010
.... This is achieved via the multiple stages of the endosomal system. AMPARs constitutively cycle through early endosomes and recycling endosomes to maintain synaptic receptor numbers. However, on induction of synaptic plasticity, subtle alterations are made to this cycle by the action of specific AMPAR-interacting...
Articles
The delivery of endocytosed cargo to lysosomes
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (5): 1019–1021.
Published: 21 September 2009
...J. Paul Luzio; Michael D.J. Parkinson; Sally R. Gray; Nicholas A. Bright In mammalian cells, endocytosed cargo that is internalized through clathrin-coated pits/vesicles passes through early endosomes and then to late endosomes, before delivery to lysosomes for degradation by proteases. Late...
Articles
ESCRTs and human disease
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (1): 167–172.
Published: 20 January 2009
...Suraj Saksena; Scott D. Emr The ESCRT (endosomal sorting complex required for transport) machinery plays a critical role in receptor down-regulation, retroviral budding, and other normal and pathological processes. The ESCRT components are conserved in all five major subgroups of eukaryotes...
Articles
Genetic analysis of ESCRT function in Drosophila : a tumour model for human Tsg101
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (1): 204–207.
Published: 20 January 2009
...Hans-Martin Herz; Andreas Bergmann Class E Vps (vacuolar protein sorting) proteins are components of the ESCRTs (endosomal sorting complexes required for transport) which are required for protein sorting at the early endosome. Most of these genes have been identified and genetically characterized...
Articles
ESCRT proteins, endosome organization and mitogenic receptor down-regulation
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (1): 146–150.
Published: 20 January 2009
...Philip Woodman Mitogenic tyrosine kinase receptors such as the EGFR (epidermal growth factor receptor) are endocytosed once they are activated at the cell surface. After reaching the early endosome, they are ubiquitinated within their cytosolic domain and are consequently sorted away from recycling...
Articles
The role of CHMP2B in frontotemporal dementia
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (1): 208–212.
Published: 20 January 2009
...Hazel Urwin; Shabnam Ghazi-Noori; John Collinge; Adrian Isaacs Mutations in the CHMP2B (charged multivesicular body protein 2B) gene that lead to C-terminal truncations of the protein can cause frontotemporal dementia. CHMP2B is a member of ESCRT-III (endosomal sorting complex required...
Articles
ESCRT proteins and the regulation of endocytic delivery to lysosomes
Available to PurchaseJ. Paul Luzio, Siân C. Piper, Katherine Bowers, Michael D.J. Parkinson, Paul J. Lehner, Nicholas A. Bright
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (1): 178–180.
Published: 20 January 2009
...J. Paul Luzio; Siân C. Piper; Katherine Bowers; Michael D.J. Parkinson; Paul J. Lehner; Nicholas A. Bright In mammalian cells, there is evidence of cargo specificity in the requirement for particular ESCRT (endosomal sorting complex required for transport) proteins to sort cargo into the luminal...
Articles
Endosome positioning during cytokinesis
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (3): 442–443.
Published: 21 May 2008
...Guillaume Montagnac; Philippe Chavrier In mammalian cells, completion of cytokinesis relies on targeted delivery of recycling membranes to the midbody. At this step of mitosis, recycling endosomes are organized as clusters located at the mitotic spindle poles as well as at both sides of the midbody...
Articles
The role of calcium and other ions in sorting and delivery in the late endocytic pathway
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 1088–1091.
Published: 25 October 2007
...J.P. Luzio; N.A. Bright; P.R. Pryor The passage of endocytosed receptor-bound ligands and membrane proteins through the endocytic pathway of mammalian cells to lysosomes occurs via early and late endosomes. The latter contain many luminal vesicles and are often referred to as MVBs (multivesicular...
Articles
Membrane traffic in cytokinesis
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (6): 1290–1294.
Published: 26 October 2005
... spatial coordinates during cleavage. In this review, we discuss recent work within the area of membrane traffic and cytokinesis. ADP-ribosylation factor 6 (Arf6) cytokinesis endosome exocyst membrane traffic Rab11 A crucial facet of mammalian cell division is the separation of two daughter...
Articles
A model for Rab GTPase localization
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (4): 627–630.
Published: 01 August 2005
... with membranes by virtue of multiple protein–protein or protein–lipid interactions. For example, EEA1 (early endosome antigen-1) binds to early endosome membranes via phosphatidylinositol 3-phosphate and Rab5 [ 2 , 3 ]. Thus if there were no pre-existing microdomains, Rab5 could enter the endocytic pathway via...
Articles
Iron targeting to mitochondria in erythroid cells
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2002) 30 (4): 735–738.
Published: 01 August 2002
...P. Ponka; A. D. Sheftel; A.-S. Zhang Immature erythroid cells have an exceptionally high capacity to synthesize haem that is, at least in part, the result of the unique control of iron metabolism in these cells. In erythroid cells the vast majority of Fe released from endosomes must cross both...
Articles
Function of Hrs in endocytic trafficking and signalling
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2001) 29 (4): 472–475.
Published: 01 August 2001
..., and it shares structural similarity with Vps27p, which is involved in vacuolar protein sorting in yeast. Since Hrs is localized to endosomes and has been implicated in the regulation of signal transduction as well as membrane trafficking, it has been regarded as a potential co-ordinator of endosomal receptor...