...Kenji Funami; Misako Matsumoto; Hiroyuki Oshiumi; Fuyuhiko Inagaki; Tsukasa Seya Toll-like receptor 4 (TLR4) recognizes lipopolysaccharide (LPS), produces pro-inflammatory cytokines and type I interferons, and associates with a trigger of endotoxin shock. TLR4 is interacted with a TIR domain...

... of infection in a plant model. GL13K kills bacteria with a minimal inhibitory concentration of 5–10 μg/ml, kills bacteria in biofilm and retains activity in 150 mM NaCl and 50% saliva. Both peptides block endotoxin action, but only GL13K appears to bind endotoxin. The peptides do not cause haemolysis...

...P. Li; M. Sun; B. Ho; J.L. Ding Sushi peptides [S1 (Sushi 1 peptide) and S3] are derived from the LPS (lipopolysaccharide; also known as endotoxin)-binding domains of an LPS-sensitive serine protease, Factor C, from the horseshoe crab ( Carcinoscorpius rotundicauda ). S1 and S3 interact at high...

...J. Weiss Lipopolysaccharide-binding protein (LBP) and bactericidal/permeability-increasing protein (BPI) are closely related endotoxin-binding proteins that function in a co-ordinated manner to facilitate an integrated host response to invading Gram-negative bacteria. Differences in the structure...

...O. Levy; G. Canny; C.N. Serhan; S.P. Colgan Among the antimicrobial proteins and peptides of humans is the cationic 55 kDa bactericidal/permeability-increasing protein (BPI), which possesses antibacterial, endotoxin-neutalizing and opsonic activity against Gram-negative bacteria. Although...

.... 1 e-mail [email protected] 13 7 2001 © 2001 Biochemical Society 2001 endotoxin infection innate immunity lipopoly-saccharide macrophage Toll-like receptors IL, interleukin LPS, lipopolysaccharide TLR, Toll-like receptor TNF, tumour necrosis factor Signal...

... be addressed. 6 8 1999 © 2000 Biochemical Society 2000 NEFA, non-esterified fatty acid TAG, triacylglycerol LPL, lipoprotein lipase TRL, triacylglycerol-rich lipoprotein VLDL, very-low-density lipoprotein endotoxin lactation lipoprotein triacylglycenol Organisms, Organs...