... are structurally similar to those found in ATP, and the high abundance of polyP in mammalian mitochondria, suggest that polyP could be involved in the regulation of the physiology of the organelle, especially in the energy metabolism. In fact, the scientific literature shows an unequivocal role for polyP not only...

... by Portland Press Limited on behalf of the Biochemical Society 2021 charge translocation energy metabolism energy transduction respiratory chains The difference in transmembrane electrochemical potential ( Δ μ ~ ), plays a central role as a biological energy currency and is used...

...-breaks, adaptive immune protection by B-cells comes with a dramatically increased risk of development of leukemia and lymphoma. Of note, B-cells exist under conditions of chronic restriction of energy metabolism. Here we discuss how these metabolic gatekeeper functions during B-cell development provide...

... of the Creative Commons Attribution Licence (CC-BY) ( http://creativecommons.org/licenses/by/3.0/ ) which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. astrocyte ATP energy metabolism glycogen glycogen phosphorylase signalling...

... of IMS proteins and the implications for mitochondrial function. 1 To whom correspondence should be addressed (email [email protected] ). 15 4 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 dual localization energy metabolism Mia40...

... kinase) pathway is induced by increased oxidative stress and JNK translocation to the mitochondrion results in impairment of energy metabolism. Moreover, IIS and JNK signalling interact with and antagonize each other. This review focuses on functional outcomes of a metabolic triad that entails the co...

... with an unprecedented function in bacteria: the anammoxosome is a prokaryotic cell organelle evolved for energy metabolism. It is an independent entity, which is enclosed by a contiguous membrane. Several lines of evidence indicate its importance in the anammox reaction and the unusual subcellular organization may well...

...K. Bender; P. Newsholme; L. Brennan; P. Maechler The coupling of cytosolic glycolytic NADH production with the mitochondrial electron transport chain is crucial for pancreatic β-cell function and energy metabolism. The activity of lactate dehydrogenase in the β-cell is low, thus glycolysis-derived...

... active-site coupling energy metabolism mammal molecular architecture 2-oxoacid dehydrogenase pyruvate dehydrogenase The mitochondrial 2-oxoacid dehydrogenase complexes are a family of large, multi-enzyme assemblies that serve as models for the study of protein–protein interactions...

...M.L. Ginger This short review summarizes recent advances in our understanding of energy metabolism within the eukaryotic flagellum. Using the example of adenylate kinase, we discuss how a requirement to target metabolic enzymes into the flagellum results in the presence of genes encoding novel...

... features, such as their specially adapted mitochondrion and the compartmentalization of glycolytic enzymes in glycosomes. The energy metabolism of Trypanosoma brucei differs significantly from that of their hosts and changes drastically during the life cycle. Despite the presence of all citric acid cycle...

... discuss metabolic engineering strategies specifically targeting energy metabolism as a strategy for yield enhancement. 1 To whom correspondence should be addressed (email [email protected] ). 3 6 2005 © 2005 The Biochemical Society 2005 crop yield energy metabolism...

...D. Carling; L.G.D. Fryer; A. Woods; T. Daniel; S.L.C. Jarvie; H. Whitrow The AMPK (AMP-activated protein kinase) cascade plays a key role in regulating energy metabolism. Conditions which cause a decrease in the ATP/AMP ratio lead to activation of AMPK. Once activated, AMPK initiates a series...