...Ramzan Umarov; Chung-Chau Hon Enhancers are genomic regions that regulate gene transcription and are located far away from the transcription start sites of their target genes. Enhancers are highly enriched in disease-associated variants and thus deciphering the interactions between enhancers...

...Hao Deng; Gaochen Jin; Bomyi Lim Proper enhancer–promoter interactions are essential to maintaining specific transcriptional patterns and preventing ectopic gene expression. Drosophila is an ideal model organism to study transcriptional regulation due to extensively characterized regulatory regions...

... of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . ATAC-seq chromatin accessibility cis -regulatory elements enhancer vertebrate development Genomic DNA is packaged into chromatin composed of repeating structural units called nucleosomes, where...

...Lan-Hsin Wang; Marvin Angelo E. Aberin; Sean Wu; Shu-Ping Wang Enhancers are cis -regulatory elements that play essential roles in tissue-specific gene expression during development. Enhancer function in the expression of developmental genes requires precise regulation, while deregulation...

... 2019 chromatin developmental biology enhancer epigenetics methylation zebrafish One of the best-studied problems in biology is the question of how a single-celled zygote gives rise to a multicellular patterned animal. Multiple model systems, including rodents (e.g. Mus musculus...

... between CD22 and GPR40 contains several evolutionarily conserved sequence blocks, among them HR2 and HR3 . β-Cell-specific expression of GPR40 is controlled at the transcriptional level through HR2, a potent β-cell-specific enhancer. The mechanisms controlling cell-specific expression of the remaining...