... that may also play an equally important role in defining drug-sensitivity. One example is the activation of parallel pathways (such as PI3K and RAL) by RAS [ 28 ]. drug response epidermal growth factor receptor (EGFR) feedback mathematical modelling mitogen-activated protein kinase (MAPK...

[email protected] ). 14 2 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 cancer drug resistance epidermal growth factor receptor (EGFR) human epidermal growth factor receptor 2 (HER2) human epidermal growth factor receptor 3 (HER3) kinase inhibition...

... the formation of EGFR complexes. 1 To whom correspondence should be addressed (email [email protected] ). 7 10 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 cortical actin dimerization epidermal growth factor receptor (EGFR) oligomerization single...

... growth factor receptor (EGFR) kinase kinase inhibitor protein kinase A (PKA) pseudokinase Oncogenic kinases have become significant targets for therapeutic interventions with small-molecule inhibitors [ 7 ]. The inhibitors that compete with ATP binding to the kinase can be roughly classified...

... endoplasmic reticulum (ER) endosomal sorting complex required for transport machinery (ESCRT machinery) epidermal growth factor receptor (EGFR) intraluminal vesicle (ILV) multivesicular endosome/body (MVB) protein tyrosine phosphatase 1B (PTP1B) Whereas ESCRT0 has been identified on clathrin...

... with the plasma membrane. 1 email [email protected] 4 8 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 epidermal growth factor receptor (EGFR) fluorescence lifetime imaging microscopy (FLIM) Förster resonance energy transfer (FRET) human...

... of the receptor could not recapitulate the in vivo binding data [ 16 ]. Instead, an unspecified ‘external’ binding site that bound the receptor dimers with high affinity was invoked to fit the experimental data [ 16 ]. epidermal growth factor (EGF) epidermal growth factor receptor (EGFR) negative co...

... cancer epidermal growth factor receptor (EGFR) ErbB juxtamembrane domain receptor tyrosine kinase The crystal structure of the complete EGFR ICD revealed that a portion of the JMA domain (residues 653–663) contained a helical segment, whereas the remaining portion (residues 645–653...

... a critical role in this phenomenon. 1 To whom correspondence should be addressed (email [email protected] ). 28 10 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 actin adhesion dimerization epidermal growth factor receptor (EGFR) integrin...

... epidermal growth factor receptor (EGFR) endosomal sorting complex required for transport (ESCRT) multivesicular body (MVB) phosphoinositide 3-kinase (PI3K) protein tyrosine phosphatase 1B (PTP1B) EGF (epidermal growth factor) binding to the EGFR (EGF receptor) promotes increased RTK (receptor...

...) endosome epidermal growth factor receptor (EGFR) His domain phosphotyrosine phosphatase (HD-PTP) multivesicular body (MVB) Down-regulation of mitogenic tyrosine kinase receptors is a process of fundamental importance, since defective receptor down-regulation results in a failure to turn off...

... 2007 Biochemical Society 2007 aldosterone epidermal growth factor receptor (EGFR) epithelial sodium channel (ENaC) hypertension protein kinase C (PKC) protein kinase D (PKD) The mineralocorticoid hormone, aldosterone, is released into the circulation by the adrenal cortex as the final...

... from [ 38 ]. © 2005 Cold Spring Harbor Laboratory Press. 1 email [email protected] 19 3 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 breast cancer cell line drug response epidermal growth factor receptor (EGFR) three-dimensional...

... 2007 The Biochemical Society 2007 diagnostics epidermal growth factor receptor (EGFR) growth factor signalling therapeutics This short review describes the work that I have been doing for the last 45 years on growth factors, their receptors and signal transduction mechanisms. When I...

[email protected] ). β2-chimaerin C1 domain diacylglycerol epidermal growth factor receptor (EGFR) phorbol ester phospholipase Cγ (PLCγ) Rac1 For many years, it has been widely conceived that PKC (protein kinase C) is the only family of intracellular receptors for the lipid second messenger DAG...

... of Sheffield, 21 July 2003 10 July 2003 © 2003 Biochemical Society 2003 epidermal growth factor receptor (EGFR) proteomics signal transduction small-molecule tyrosine kinase inhibitor surrogate marker two-dimensional electrophoresis Abbreviations used: SMTKI, small-molecule...

... of two receptor molecules, Key words: a disintegrin and metalloprotease (ADAM), cancer, cross-talk, epidermal growth factor receptor (EGFR), G-protein-coupled receptor (GPCR), transactivation. Abbreviations used: ADAM, a disintegrin and metalloprotease; ET-1, endothelin-1; EGF, epidermal growth factor...