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Keywords: epidermal growth factor receptor (EGFR)
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Articles
Biochem Soc Trans (2014) 42 (4): 831–836.
Published: 11 August 2014
... in models of resistant cancers, as well as in patients. In the present article, we describe some of the roles in which HER3 can mediate acquired resistance and discuss the current efforts to target HER3 itself in cancer. cancer drug resistance epidermal growth factor receptor (EGFR) human epidermal...
Articles
Biochem Soc Trans (2014) 42 (4): 770–775.
Published: 11 August 2014
... ). 7 5 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 drug response epidermal growth factor receptor (EGFR) feedback mathematical modelling mitogen-activated protein kinase (MAPK) signalling Aberrant signalling by the MAPK (mitogen-activated protein...
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Articles
Biochem Soc Trans (2013) 41 (4): 1083–1088.
Published: 18 July 2013
... growth factor receptor (EGFR) kinase kinase inhibitor protein kinase A (PKA) pseudokinase Oncogenic kinases present significant drug targets for directed chemotherapy [ 7 ]. Small-molecule inhibitors that prevent oncogenic kinases from binding ATP (and subsequently performing phosphotransfer...
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Biochem Soc Trans (2012) 40 (2): 464–468.
Published: 21 March 2012
... endoplasmic reticulum (ER) endosomal sorting complex required for transport machinery (ESCRT machinery) epidermal growth factor receptor (EGFR) intraluminal vesicle (ILV) multivesicular endosome/body (MVB) protein tyrosine phosphatase 1B (PTP1B) Following EGF (epidermal growth factor)-induced...
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Articles
Biochem Soc Trans (2012) 40 (1): 15–19.
Published: 19 January 2012
... receptor is positively linked with dimer assembly, but shows negative co-operativity within the dimer. 1 email [email protected] 31 5 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 epidermal growth factor (EGF) epidermal growth factor receptor (EGFR...
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Biochem Soc Trans (2012) 40 (1): 195–199.
Published: 19 January 2012
... be valuable to understand the contribution of the JMA–lipid interaction to catalytic activity. 24 8 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 cancer epidermal growth factor receptor (EGFR) ErbB juxtamembrane domain receptor tyrosine kinase EGF...
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Biochem Soc Trans (2011) 39 (2): 568–573.
Published: 22 March 2011
... a critical role in this phenomenon. actin adhesion dimerization epidermal growth factor receptor (EGFR) integrin tetraspanin © The Authors Journal compilation © 2011 Biochemical Society 2011 28 10 2010 1 To whom correspondence should be addressed (email e.odintsova...
Articles
Biochem Soc Trans (2009) 37 (1): 173–177.
Published: 20 January 2009
... epidermal growth factor receptor (EGFR) endosomal sorting complex required for transport (ESCRT) multivesicular body (MVB) phosphoinositide 3-kinase (PI3K) protein tyrosine phosphatase 1B (PTP1B) EGF (epidermal growth factor) binding to the EGFR (EGF receptor) promotes increased RTK (receptor...
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Biochem Soc Trans (2009) 37 (1): 146–150.
Published: 20 January 2009
...) endosome epidermal growth factor receptor (EGFR) His domain phosphotyrosine phosphatase (HD-PTP) multivesicular body (MVB) Down-regulation of mitogenic tyrosine kinase receptors is a process of fundamental importance, since defective receptor down-regulation results in a failure to turn off...
Articles
Biochem Soc Trans (2007) 35 (5): 1049–1051.
Published: 25 October 2007
... 2007 Biochemical Society 2007 aldosterone epidermal growth factor receptor (EGFR) epithelial sodium channel (ENaC) hypertension protein kinase C (PKC) protein kinase D (PKD) The mineralocorticoid hormone, aldosterone, is released into the circulation by the adrenal cortex as the final...
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Biochem Soc Trans (2007) 35 (4): 665–668.
Published: 20 July 2007
... compilation © 2007 Biochemical Society 2007 breast cancer cell line drug response epidermal growth factor receptor (EGFR) three-dimensional extracellular matrix culture tumour necrosis factor α (TNFα) tumour necrosis factor α-converting enzyme (TACE) Studying cells ex vivo...
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Biochem Soc Trans (2007) 35 (1): 1–6.
Published: 22 January 2007
... 2007 The Biochemical Society 2007 diagnostics epidermal growth factor receptor (EGFR) growth factor signalling therapeutics This short review describes the work that I have been doing for the last 45 years on growth factors, their receptors and signal transduction mechanisms. When I...
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Biochem Soc Trans (2006) 34 (5): 855–857.
Published: 25 October 2006
... the access to the lipid second messenger. β2-chimaerin C1 domain diacylglycerol epidermal growth factor receptor (EGFR) phorbol ester phospholipase Cγ (PLCγ) Rac1 Information Processing and Molecular Signalling: A Focus Topic at BioScience2006, held at SECC Glasgow, U.K., 23–27 July...
Articles
Biochem Soc Trans (2003) 31 (6): 1488–1490.
Published: 01 December 2003
... of Sheffield, 21 July 2003 10 July 2003 © 2003 Biochemical Society 2003 epidermal growth factor receptor (EGFR) proteomics signal transduction small-molecule tyrosine kinase inhibitor surrogate marker two-dimensional electrophoresis Abbreviations used: SMTKI, small-molecule...
Articles
Biochem Soc Trans (2003) 31 (6): 1203–1208.
Published: 01 December 2003
... (ADAM) cancer cross-talk epidermal growth factor receptor (EGFR) G-protein-coupled receptor (GPCR) transactivation Abbreviations used: ADAM, a d isintegrin a nd m etalloprotease; ET-1, endothelin-1; EGF, epidermal growth factor; EGFR, epidermal growth factor receptor; ERK...