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Keywords: epigenetics
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Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (5): 2059–2075.
Published: 24 October 2024
...Willow Rolls; Marcus D. Wilson; Duncan Sproul DNA methylation is a repressive epigenetic mark that is pervasive in mammalian genomes. It is deposited by DNA methyltransferase enzymes (DNMTs) that are canonically classified as having de novo (DNMT3A and DNMT3B) or maintenance (DNMT1) function...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (5): 2203–2214.
Published: 08 October 2024
...Yuelin Zhang; Jiahui Li; Li Tan; Jun Xue; Yujiang Geno Shi Epigenetic mechanisms play a critical role in the pathogenesis of human diseases including kidney disorders. As the erasers of DNA methylation, Ten-eleven translocation (TET) family proteins can oxidize 5-methylcytosine (5mC) to 5...
Articles
In Collection
Epigenetics
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (4): 1827–1839.
Published: 18 July 2024
... BY-NC-ND) . chromatin epigenetics single-cell In multicellular organisms, a single common genomic DNA sequence is decoded in a multitude of different ways to give rise to the vast array of different cellular states that are present in the organism. A fundamental question is how...
Articles
In Collection
Epigenetics
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (3): 1349–1362.
Published: 16 May 2024
... have advanced our understanding of TEs in preimplantation, as well as their epigenetic regulation and functional roles. However, many questions remain about the implications of TE expression during early development. Challenges originate first due to the abundance of TEs in the genome, and second...
Articles
In Collection
Epigenetics
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (1): 217–229.
Published: 22 February 2024
.... Shifting this balance in any direction disrupts the tight equilibrium and tips cells into an altered epigenetic and phenotypic space, facilitating both developmental and cancer processes. Correspondence: Melanie A. Eckersley-Maslin ( [email protected] ) 21 11 2023 5 2...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2024) 52 (1): 55–63.
Published: 09 February 2024
... interest in the ability of the molecules to epigenetically rewire cells to ‘resolve and repair’ phenotypes. Here, we review and discuss these new data in the context of their potential for exploitation in identifying novel gene signatures for the development of advanced and safe therapeutics for chronic...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (3): 1035–1046.
Published: 12 May 2023
... information, they can take on similar or different cell fates, resulting from a symmetric or asymmetric division. These fates can be modulated by epigenetic mechanisms that can alter gene expression without changing genetic information. Histone proteins, which wrap DNA into fundamental units of chromatin...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (3): 1215–1225.
Published: 17 May 2022
...So Young Park; Jungnam Cho; Dong-Hoon Jeong Plant small RNAs (sRNAs) are short non-coding RNAs that are implicated in various regulatory processes involving post-transcriptional gene silencing and epigenetic gene regulation. In epigenetic regulation, sRNAs are primarily involved in RNA-directed DNA...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (3): 1179–1190.
Published: 06 May 2022
...Peter Sarkies DNA methylation is an epigenetic modification with a very long evolutionary history. However, DNA methylation evolves surprisingly rapidly across eukaryotes. The genome-wide distribution of methylation diversifies rapidly in different lineages, and DNA methylation is lost altogether...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (2): 723–736.
Published: 14 March 2022
...Marco Morselli; Giorgio Dieci Recent investigations on the non-protein-coding transcriptome of human cells have revealed previously hidden layers of gene regulation relying on regulatory non-protein-coding (nc) RNAs, including the widespread ncRNA-dependent regulation of epigenetic chromatin states...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 583–596.
Published: 25 February 2022
... in the patterns of DNA methylation have the potential to provide for epigenetic inheritance of traits. Contemporary epigenomic technologies provide information beyond sequence variation and could supply alternative sources of trait variation for improvement in crops such as sorghum. Yet, compared with other...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 487–497.
Published: 07 January 2022
... found to this epidemic. Over the last decade, there has been a tremendous advancement in understanding the science of epigenetics, as well as a rise in public interest in learning more about the influence of diet and lifestyle choices on the health of an individual. Without affecting the underlying DNA...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (6): 2549–2560.
Published: 09 December 2021
... ) 20 10 2021 19 11 2021 23 11 2021 © 2021 The Author(s) 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . chromatin epigenetics lncRNA...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (6): 2639–2653.
Published: 08 November 2021
[email protected] ) * These authors contributed equally to this work. 5 8 2021 21 9 2021 18 10 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 chromatin cryo-electron microscopy epigenetics eukaryotic gene expression...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (5): 2431–2441.
Published: 28 October 2021
...-translational modification. Perturbation to these networks leads to genomic instability and disease, presenting epigenetic proteins as key therapeutic targets. This mini-review will describe progress in mapping the combinatorial histone PTM landscape, and recent chemical biology approaches to map histone...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (5): 2073–2079.
Published: 13 October 2021
.... Correspondence: Yang Yu ( [email protected] ) 29 3 2021 6 9 2021 15 9 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 epigenetics gene silencing piRNA transposons Genome integrity of eukaryotes is constantly...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (4): 1867–1879.
Published: 02 August 2021
... Commons Attribution License 4.0 (CC BY) . chromatin CTCF epigenetics genomic imprinting non-coding RNA Diverse genetic and epigenetic systems of mono-allelic expression have evolved in mammals, together controlling thousands of genes [ 1 ]. These mono-allelic gene expression mechanisms...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (3): 1041–1054.
Published: 22 June 2021
... 4.0 (CC BY-NC-ND) . cancer enhancer epigenetics gene expression and regulation H3K4 histone lysine methyltransferase It remains puzzled whether H3K4me1 has any function within enhancers, or could just be a side-product of MLL3/4 as a hallmark of enhancer landscape. In conjunction...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (2): 867–880.
Published: 26 March 2021
... [ 62 , 71 , 82 ]. Correspondence: Yi Zhu ( [email protected] ) or Gerald W. Hart ( [email protected] ) 15 1 2021 1 3 2021 3 3 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 DNA synthesis and repair epigenetics...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (1): 71–77.
Published: 22 February 2021
... epigenetic memory elements of PRC2-mediated silencing. As these marks are stored locally in the chromatin, PRC2-based memory is a cis -acting system. A key feature of stable epigenetic memory in cis is PRC2-mediated, self-reinforcing feedback from K27-methylated histones onto nearby histones in a read-write...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (6): 2891–2902.
Published: 18 December 2020
...Mélanie A. Eckersley-Maslin The concept of cellular plasticity is particularly apt in early embryonic development, where there is a tug-of-war between the stability and flexibility of cell identity. This balance is controlled in part through epigenetic mechanisms. Epigenetic plasticity dictates how...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (4): 1609–1621.
Published: 14 August 2020
...William A. Flavahan Epigenetic processes converge on chromatin in order to direct a cell's gene expression profile. This includes both maintaining a stable cell identity, but also priming the cell for specific controlled transitions, such as differentiation or response to stimuli. In cancer...
Articles
In Collection
Protein structure and function
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (4): 1751–1763.
Published: 11 August 2020
...Alexandra D. Gurzau; Marnie E. Blewitt; Peter E. Czabotar; James M. Murphy; Richard W. Birkinshaw The structural maintenance of chromosomes hinge domain containing protein 1 (SMCHD1) is a large multidomain protein involved in epigenetic gene silencing. Variations in the SMCHD1 gene are associated...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (4): 1697–1706.
Published: 29 July 2020
... identified in model plant Arabidopsis thaliana , the methyltransferase CURLY LEAF (CLF) and its catalyzed histone H3 Lysine 27 trimethylation (H3K27me3) have already become well-established paradigm in plant epigenetic study. Like in animals, PcG proteins mediate plant development and repress homeotic gene...
Articles
In Collection
Embryonic development
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (3): 1019–1034.
Published: 15 June 2020
...Rachel M. Woodhouse; Alyson Ashe Gene regulatory information can be inherited between generations in a phenomenon termed transgenerational epigenetic inheritance (TEI). While examples of TEI in many animals accumulate, the nematode Caenorhabditis elegans has proven particularly useful...
Articles
In Collection
Embryonic development
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (2): 581–593.
Published: 22 April 2020
... 27 3 2020 30 3 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 centromere embryo epigenetics histone chaperone nucleolus ribosomes The nucleolus is the most prominent nuclear organelle in almost all cells...
Articles
In Collection
Embryonic development
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (3): 875–885.
Published: 17 June 2019
... acid (RA) increase expression of Tet2 and Tet3 through binding to conserved RA-responsive elements [ 24 ]. cell differentiation epigenetics epigenomics methylation model organisms pluripotency Genome-wide profiling of 5hmC and TET1 protein binding sites have revealed enrichment...
Articles
In Collection
Embryonic development
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (2): 713–724.
Published: 05 April 2019
... 2019 chromatin developmental biology enhancer epigenetics methylation zebrafish One of the best-studied problems in biology is the question of how a single-celled zygote gives rise to a multicellular patterned animal. Multiple model systems, including rodents (e.g. Mus musculus...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (2): 691–700.
Published: 22 March 2019
... 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 chromatin developmental biology Drosophila melanogaster epigenetics The packaging of DNA into chromatin underlies the control of gene expression in all eukaryotic cells and plays a major...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (4): 957–966.
Published: 31 July 2018
...-nucleosome DNA (linker DNA) is bound by H1, which further organizes nucleosomes into higher-order chromatin structures [ 3 ]. The histones are subjected to diverse post-translational modifications, e.g. acetylation, methylation, phosphorylation and ubiquitination, which index chromatin and epigenetically...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (3): 577–586.
Published: 20 April 2018
...Andrew Keniry; Marnie E. Blewitt Single-cell genomics is set to revolutionise our understanding of how epigenetic silencing works; by studying specific epigenetic marks or chromatin conformations in single cells, it is possible to ask whether they cause transcriptional silencing or are instead...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2017) 45 (2): 323–338.
Published: 13 April 2017
...Maïté Leturcq; Tony Lefebvre; Anne-Sophie Vercoutter-Edouart Post-translational modifications of histones and the dynamic DNA methylation cycle are finely regulated by a myriad of chromatin-binding factors and chromatin-modifying enzymes. Epigenetic modifications ensure local changes...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 1037–1042.
Published: 11 August 2014
... (email [email protected] ). 14 5 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 acetyl-CoA acetylation epigenetics metabolism Fundamental aspects of the regulation of cell growth and proliferation remain incompletely understood...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 945–951.
Published: 11 August 2014
...Margreet C.M. Vissers; Caroline Kuiper; Gabi U. Dachs There is growing interest in the family of 2-OG (2-oxoglutarate)-dependent dioxygenase enzymes that catalyse the hydroxylation of a wide range of organic targets. Members of this family that regulate the cell's hypoxic response and epigenetic...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (2): 582–586.
Published: 20 March 2014
... the suffering of the next generation. 1 email [email protected] 15 10 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 cortisol depression epigenetics hypothalamic–pituitary–adrenal axis intergenerational transmission maternal care pregnancy...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (2): 569–581.
Published: 20 March 2014
... and boosting mechanisms underlying learning, drug development in this field aims at designing CBT-augmenting compounds that help to overcome extinction learning deficits, promote long-term fear inhibition and thus support relapse prevention. Progress in revealing the role of epigenetic regulation of specific...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (3): 697–699.
Published: 23 May 2013
...Adele Murrell; Paul J. Hurd; Ian C. Wood Our advances in technology allow us to sequence DNA to uncover genetic differences not only between individuals, but also between normal and diseased cells within an individual. However, there is still a lot we have yet to understand regarding the epigenetic...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (3): 797–801.
Published: 23 May 2013
... in the mechanisms which define and maintain β-cell identity. The advent of genome-wide analyses of chromatin modifications has highlighted the role of epigenetic factors in determining cell identity. There is also evidence from both human populations and animal models for an epigenetic component in susceptibility...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (3): 751–759.
Published: 23 May 2013
...Diego Molina-Serrano; Vassia Schiza; Antonis Kirmizis Epigenetic modifications, including those occurring on DNA and on histone proteins, control gene expression by establishing and maintaining different chromatin states. In recent years, it has become apparent that epigenetic modifications do...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (3): 711–719.
Published: 23 May 2013
... of pluripotent cells in vitro . Recent studies have, however, found that the choice of culture condition has a significant impact on epigenetic profiles of cultured pluripotent cells. Mouse and human ESCs (embryonic stem cells) show substantial epigenetic differences that are dependent on the culture condition...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (3): 783–788.
Published: 23 May 2013
...-transformed, auto-aggressive phenotype typified by loss of contact inhibition, reduced apoptosis and the production of matrix-degrading enzymes. The mechanisms involved in the development of this phenotype are unclear; however, increasing evidence implicates alterations in the epigenetic regulation of gene...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (3): 727–740.
Published: 23 May 2013
... simultaneous access to the major and minor groove [ 21 ]. Therefore ZF-CxxC domain-mediated recognition of CGI DNA in vivo requires both the presence of non-methylated CpG dinucleotides and accessible internucleosomal DNA. chromatin CpG island DNA demethylation DNA methylation epigenetics...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (3): 803–807.
Published: 23 May 2013
...Sanne D. van Otterdijk; John C. Mathers; Gordon Strathdee DNA methylation is an important epigenetic mechanism in mammalian cells. It occurs almost exclusively at CpG sites and has a key role in a number of biological processes. It plays an important part in regulating chromatin structure and has...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (3): 789–796.
Published: 23 May 2013
... expression programme is largely driven through epigenetic mechanisms such as post-translational histone modifications and DNA methylation. In the last few years, the distinct functions of histone modifications and of the enzymes catalysing their formation have begun to be elucidated in processes important...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (4): 637–639.
Published: 22 July 2008
... this epigenetic silencing is overturned. A key event is the activation of the viral protein Zta with three ZREs (Zta-response elements) from the BRLF1 promoter (referred to as Rp). Two of these ZREs contain CpG motifs and are methylated in the latent genome. Biochemical analyses and molecular modelling of Zta...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (3): 618–622.
Published: 22 May 2007
... libraries. These retrotransposons can act as alternative promoters and first exons for diverse genes, synchronizing their expression. Heritable genetic change due to replication of these retrotransposons probably occurs specifically in oocytes and early embryos. ERVs are usually epigenetically silenced...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (6): 1148–1150.
Published: 25 October 2006
... biodiversity epigenetics imprinting natural antisense non-coding RNA transcription More than two decades have passed since endogenously transcribed antisense RNA was first described in mammals [ 1 ], while in the last year thousands of examples of ncNAT [non-coding NAT (natural antisense)] have...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (4): 709–711.
Published: 01 August 2005
... [ 4 ]. These epigenetic effects prompted the authors to suggest that chronic supplementation of humans with folates may modify gene expression in unexpected and not necessarily beneficial ways. It has previously been reported that low folate status is associated with global hypomethylation of DNA...
