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Keywords: exosite inhibitor
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A. Amour, J. Hutchinson, A.M. Ruiz Avendaño, S. Ratcliffe, E. Alvarez, J. Martin, J.R. Toomey, S. Senger, M. Wolfendale, C. Mooney
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (3): 555–558.
Published: 22 May 2007
... categorized with deconvolution assays into either active-site or exosite inhibitors. The latter category of hits displayed both competitive and uncompetitive modalities of inhibition with respect to Factor X activation. An uncompetitive mechanism of action is of particular interest as it offers a hypothetical...
