... membrane proteins exosomes extracellular vesicles Several non-exclusive hypotheses have been explored regarding the roles of tetraspanins in EVs: (1) regulation of EV formation; (2) regulation of EV functional properties, including uptake and fusion; and (3) regulation of EV composition. However...

... 2019 The Author(s) 2019 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . EVs exosomes extracellular vesicles nanovesicles OMV outer membrane vesicles...

... of the Biochemical Society 2019 diagnosis exosomes extracellular vesicles liquid biopsy miRNAs ovarian cancer Ovarian cancer (OC) is the seventh most commonly diagnosed cancer in women and the disease causes more than 150 000 deaths around the world each year, making it the deadliest gynecological...

... exosomes and microvesicles are implicated in cell–cell communication, immune response, tissue repair, epigenetic regulation, and in various diseases including cancer. It has been reported that these EVs regulate cancer progression, metastasis, organotropism and chemoresistance. In recent times, the role...

... processes. Furthermore, tetraspanin complexes are located in specialized microdomains, called tetraspanin-enriched microdomains (TEMs). TEMs provide a signaling platform and are poised for invagination and vesicle formation. These vesicles can be released as exosomes (Exo) and are important in cell contact...