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Keywords: extracellular matrix
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Articles
Biochem Soc Trans (2024) 52 (3): 1489–1502.
Published: 10 June 2024
...Matteo Golo; Peter L. H. Newman; Daryan Kempe; Maté Biro The tumor microenvironment (TME) is a complex and dynamic ecosystem that adjoins the cancer cells within solid tumors and comprises distinct components such as extracellular matrix, stromal and immune cells, blood vessels, and an abundance...
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Biochem Soc Trans (2023) 51 (1): 387–401.
Published: 06 February 2023
... with CAUL. 3D culture bioengineering bioprinting cell cultures extracellular matrix macrophages There are numerous biochemical and biophysical parameters which influence macrophage phenotype and function particularly immunogenic pathogens and cytokines. However, there is emerging...
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Biochem Soc Trans (2022) 50 (2): 1003–1012.
Published: 11 April 2022
... and POGLUT3 were identified as two novel O -glucosyltransferases that modify a few Notch EGF repeats at sites distinct from those modified by POGLUT1. Comparison of these modification sites revealed a putative consensus sequence which predicted modification of many extracellular matrix proteins including...
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Biochem Soc Trans (2021) 49 (6): 2611–2625.
Published: 16 December 2021
...Abir Chakraborty; Adrienne Lesley Edkins The extracellular matrix (ECM) is a dynamic and organised extracellular network assembled from proteins and carbohydrates exported from the cell. The ECM is critical for multicellular life, providing spatial and temporal cellular cues to maintain tissue...
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Biochem Soc Trans (2020) 48 (6): 2539–2555.
Published: 05 November 2020
...Amir M. Alsharabasy; Sharon A. Glynn; Abhay Pandit The extracellular matrix (ECM) dynamics in tumour tissue are deregulated compared to the ECM in healthy tissue along with disorganized architecture and irregular behaviour of the residing cells. Nitric oxide (NO) as a pleiotropic molecule exerts...
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Biochem Soc Trans (2020) 48 (5): 2335–2345.
Published: 14 October 2020
...Samuel Lewin; Stuart Hunt; Daniel W. Lambert Extracellular vesicles (EV) are implicated in a variety of functions affecting the extracellular matrix (ECM), including matrix degradation, cross-linking of matrix proteins and matrix calcification. These processes are important in many physiological...
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Biochem Soc Trans (2020) 48 (4): 1433–1445.
Published: 14 August 2020
... 21 7 2020 24 7 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 biofabrication extracellular matrix molecular scaffolds osteoarthritis tissue engineering In healthy joint tissue, a layer of subchondral bone (SCB...
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Biochem Soc Trans (2020) 48 (3): 755–764.
Published: 05 May 2020
... consistently promote bone regeneration. bone developmental engineering extracellular matrix skeletal tissue engineering The adult human skeleton consists of 206 individual bones divided across five major categories — long (e.g. femur, humerus), short (e.g. tarsal, carpal), flat (e.g. skull...
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Biochem Soc Trans (2019) 47 (6): 1661–1678.
Published: 22 November 2019
...Jessica L. Chitty; Yordanos F.I. Setargew; Thomas R. Cox The extracellular matrix (ECM) is a fundamental component of tissue microenvironments and its dysregulation has been implicated in a number of diseases, in particular cancer. Tumour desmoplasia (fibrosis) accompanies the progression of many...
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Biochem Soc Trans (2019) 47 (1): 101–108.
Published: 17 December 2018
...Mohammad Zahied Johan; Michael S. Samuel Reciprocal biochemical and biophysical interactions between tumor cells, stromal cells and the extracellular matrix (ECM) result in a unique tumor microenvironment that determines disease outcome. The cellular component of the tumor microenvironment...
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Biochem Soc Trans (2018) 46 (3): 631–639.
Published: 09 May 2018
... 3 4 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 eicosanoid extracellular matrix inflammation macrophage ACdEV apoptotic cell-derived extracellular vesicles COX cyclooxygenase CX3CL1 chemokines...
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Biochem Soc Trans (2016) 44 (5): 1465–1473.
Published: 19 October 2016
... cellular environments. The extracellular matrix contains information regarding tissue architecture and its mechanical properties that is transmitted to the cell via integrin receptors. In this review, I describe various examples of modulation of the BMP pathway by integrins. In the case of the Drosophila...
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Biochem Soc Trans (2015) 43 (3): 482–488.
Published: 01 June 2015
... dynamics and the extracellular matrix (ECM), showing that Cx43 plays diverse roles in co-ordinating wound closure events. It is clear that both CMPs and antisense oligonucleotides hold therapeutic potential, however maintaining Cx43 expression may be beneficial to the cell by preserving other non-channel...
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Biochem Soc Trans (2015) 43 (1): 122–128.
Published: 26 January 2015
...Katarzyna I. Wolanska; Mark R. Morgan The biophysical, mechanical and chemical characteristics of extracellular matrixes influence many cellular functions to control tissue homoeostasis and drive progression of cancer and inflammatory diseases. To maintain normal tissue function, fibronectin-rich...
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Biochem Soc Trans (2013) 41 (4): 995–1001.
Published: 18 July 2013
... and functional characterization of ILK and the long-standing debate regarding its reported kinase activity. © The Authors Journal compilation © 2013 Biochemical Society 2013 actin cell adhesion extracellular matrix integrin-linked kinase (ILK) pseudokinase signalling In order to establish...
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Biochem Soc Trans (2007) 35 (5): 849–852.
Published: 25 October 2007
... to structural changes deleterious to function. Finally, the extracellular matrix of vascular tissue is a multicomponent system and the role of other major constituents, such as elastin and glycosaminoglycans, in modifying tissue properties should be considered. Some details of newer methods being developed...
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Biochem Soc Trans (2007) 35 (4): 695–697.
Published: 20 July 2007
... of tissue repair. These events must be tightly regulated. Excessive deposition of scar tissue is the major hallmark of fibrotic disease. Tenascin-C is an extracellular matrix glycoprotein that is transiently expressed upon tissue injury, where it is specifically localized to the wound edge, and persistently...
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Biochem Soc Trans (2007) 35 (4): 643–646.
Published: 20 July 2007
... pathways, and these in turn can lead to changes in matrix turnover. This is a long way from the traditional view of the role of the extracellular matrix, or ‘ground substance’, in filling the spaces between the cells and providing physical support for them. Just over 100 delegates assembled at Sheffield...
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Biochem Soc Trans (2007) 35 (4): 689–691.
Published: 20 July 2007
..., they may play an important role in neural plasticity, including remodelling of synaptic connections. Moreover, it has been demonstrated recently that at a certain disease phase they may have an important regenerative role [ 10 ]. CNS central nervous system ECM extracellular matrix Hpx...
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Biochem Soc Trans (2007) 35 (4): 672–676.
Published: 20 July 2007
... (extracellular matrix) during ovulation is critically dependent on the catalysis of HC·HA generation by TSG-6, with TSG - 6 −/− mice being female infertile because of failure of HA cross-linking. It has been shown recently that TSG-6-mediated HC·HA formation is essential for the formation of HA-rich pericellular...
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Biochem Soc Trans (2007) 35 (4): 692–694.
Published: 20 July 2007
...G. Haddock; A.K. Cross; S. Allan; B. Sharrack; J. Callaghan; R.A.D. Bunning; D.J. Buttle; M.N. Woodroofe The ECM (extracellular matrix) is a complex molecular framework that provides physical support to cells and tissues, while also providing signals for cell growth, migration, differentiation...
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Biochem Soc Trans (2006) 34 (6): 1261–1266.
Published: 25 October 2006
...G.J. del Zoppo; R. Milner; T. Mabuchi; S. Hung; X. Wang; J.A. Koziol The integrity of the cerebral microvasculature depends on the interaction between its component cells and the extracellular matrix, as well as reorganized cell–cell interactions. In the central nervous system, matrix adhesion...
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Biochem Soc Trans (2006) 34 (3): 454–455.
Published: 22 May 2006
... and Structure: Biochemical Society Focused Meeting held at Royal Holloway University of London, Egham Hill, U.K., 9–10 January 2006. Organized and edited by B. Mulloy (NIBSC, U.K.) and C. Rider (Royal Holloway University of London, U.K.). ECM extracellular matrix HS heparan sulphate HSPG HS...
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Biochem Soc Trans (2005) 33 (6): 1254–1255.
Published: 26 October 2005
...J.R. Higginson; S.J. Winder Dystroglycan, a ubiquitous membrane-spanning cell adhesion molecule, is a crucial link between the actin cytoskeleton and the extracellular matrix. With a wide expression pattern and multiple interacting proteins, not only is dystroglycan now thought to be important...
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Biochem Soc Trans (2004) 32 (3): 438–442.
Published: 01 June 2004
... © 2004 Biochemical Society 2004 adhesion epidermal growth factor (EGF) extracellular matrix growth factor receptor integrin signalling Abbreviations used: EGF(R), epidermal growth factor (receptor); Egr-1, early growth response gene product 1; ERK, extracellular-signal...