... in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with CAUL. cytokines extracellular signal-regulated kinases inflammation innate immunity receptor signalling Toll-like receptors Cells utilise a range...

.... Correspondence: Channing J. Der ( [email protected] ) 13 10 2020 30 12 2020 8 1 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 extracellular signal-regulated kinases mitogen-activated protein kinases PDAC RAS GTPase...

... with JISC. extracellular signal-regulated kinases kinases paradoxical activation small molecules Protein kinases play key roles in a variety of diseases including cancer and inflammation and have emerged as ‘druggable’ enzymes [ 1 ]. By 2019 some 48 small molecule protein kinase inhibitors...

... abnormalities have been discovered in hearts of mouse models of cardiomyopathy caused by LMNA mutations that contribute to pathogenesis. These include abnormally increased signaling by extracellular signal-regulated kinase 1 and kinase 2 and other mitogen-activated protein kinases, protein kinase B/mammalian...

... alive, we were inspired to represent them as ‘zombies' ( Figure 1 ). We will show later how our work on the pseudophosphatase STYX (serine/threonine/tyrosine interacting protein) conforms to these basic modes of action. extracellular signal-regulated kinases FBXW7 pseudoenzyme...

... biology extracellular signal-regulated kinases The extracellular signal-regulated kinase (ERK) pathway is a highly conserved signaling cascade critically regulating cell morphology, migration, metabolism, proliferation, differentiation, and survival. In response to extracellular stimuli relayed...