... conditions such as neurodegenerative diseases. Depending on the stimulus received, microglia cells dynamically change their phenotype releasing specific soluble factors and largely modify the cargo of their secreted extracellular vesicles (EVs). Despite the mechanisms at the basis of microglia actions have...

...Hannah Clemmens; Daniel W. Lambert Extracellular vesicles (EVs) are a heterogeneous group of small lipid-enclosed structures with myriad roles in physiology and disease. The recent surge of interest in EVs has led to greater understanding of their biology and appreciation of how they might...

...Jameel M. Inal; Una Fairbrother; Sheelagh Heugh The important roles of extracellular vesicles in the pathogenesis of various diseases are rapidly being elucidated. As important vehicles of intercellular communication, extracellular vesicles, which comprise microvesicles and exosomes, are revealing...

... 2 van der Pol E. Boing A.N. Harrison P. Sturk A. Nieuwland R. Classification, functions, and clinical relevance of extracellular vesicles Pharmacol. Rev. 2012 64 676 705 3 Simons M. Raposo G. Exosomes: vesicular carriers for intercellular communication...

... extracellular vesicle milk fat globule–epidermal growth factor–Factor VIII protein (Mfge8) Rab27a tumour immunity Communication between cells is a fundamental process in pluricellular organisms. This is especially the case in the context of growing tumours, which can modulate their direct...

...Karen M.K. de Vooght; Cedric Lau; Pim P.M. de Laat; Richard van Wijk; Wouter W. van Solinge; Raymond M. Schiffelers Blood contains a mixture of extracellular vesicles from different cell types, primarily platelets, endothelial cells, leucocytes and erythrocytes. Erythrocytes are the most abundant...