... component of the nuclear envelope. Impaired processing results in aberrant retention of a farnesyl group at the C-terminus of lamin A, leading to altered membrane dynamics. It has been widely proposed that persistence of the farnesyl moiety is the major factor responsible for the disease, prompting clinical...

... are farnesyl pyrophosphate and geranylgeranyl pyrophosphate [ 14 ]. The inhibition of cholesterol and isoprenoid biosyntheses is dependent upon statin concentration; low-dose statins, in the range 1–20 μM, preferentially reduce isoprenoid synthesis [ 15 ] without influencing cellular cholesterol levels [ 16...

...-rich rafts [ 7 ]. Protein farnesylation is usually a precursor to protein palmitoylation and promotes membrane retention [ 8 ]. There has been little research into the role of protein lipidation in the production of Aβ. We have shown that LOVA prevents the palmitoylation of BACE, resulting...