...) 2024 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . feedback mechanics precision robustness somite symmetry A prevalent feature of embryonic...

..., polarity and secretion of a range of biologically active components. Recent studies highlight that spatio-temporal regulation of Hippo pathway components are central to precisely controlling its context-dependent dynamic activity. Several levels of feedback are integrated into the Hippo pathway, which...

... entered clinical trials. However, resistance to these inhibitors, either intrinsic to the tumour or acquired during treatment, remains a major problem in targeted therapeutics. One of the mechanisms by which tumours become resistant is the rewiring of the signalling networks via feedback, by which...

... of the cell and appropriately dictates whether the cell will actively favour energy- and amino-acid-consuming anabolic processes such as cellular growth, or energy- and amino-acid-generating catabolic processes such as autophagy. The present review discusses important feedback mechanisms between these three...

... cell cycles are always driven by a negative-feedback loop amplified by double-negative feedbacks (antagonism). 1 To whom correspondence should be addressed (email [email protected] ). 8 3 2010 The high Cdk activity state is stabilized by the mitotic checkpoint...

...O. Wolkenhauer; S.N. Sreenath; P. Wellstead; M. Ullah; K.-H. Cho A mathematical understanding of regulation, and, in particular, the role of feedback, has been central to the advance of the physical sciences and technology. In this article, the framework provided by systems biology is used to argue...

... and differentiation. enzyme feedback kinetics non-linearity oscillation Abbreviations used: PFK, phosphofructokinase; BZ reaction, Belousov–Zhabotinskii reaction; PO, peroxidase-oxidase. The Behaviour of Enzymes in Cells 719 Implications of enzyme kinetics A.G. McDonald Department of Biochemistry...

... of PCr recovery defines the kinetics of oxygen supply and substrate utilization. The second principle is the constancy of PCr and H+ (lactate) production by glycogenolysis due to the coupling of ATPase and glycolysis. This principle enables glycogenolytic flux to be measured from Key words: ATP, feedback...